Long-acting antibacterial and anticoagulant material as well as preparation method and application thereof

A long-acting, base material technology, applied in the field of medical materials, can solve the problems of easy thrombosis and infection, insufficient anticoagulant performance, and insufficient antibacterial performance, and achieve the effect of long release cycle and prolonged release time.

Active Publication Date: 2022-05-06
SOUTHWEST JIAOTONG UNIV
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is an urgent need to overcome the anticoagulant and antibacterial modification technology on the surface of implant materials to solve the problems of anticoagulant performance, Insufficient antibacterial performance, easy to cause problems of blood clots and infections

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Long-acting antibacterial and anticoagulant material as well as preparation method and application thereof
  • Long-acting antibacterial and anticoagulant material as well as preparation method and application thereof
  • Long-acting antibacterial and anticoagulant material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0037] Embodiments of the present invention provide a method for preparing a long-acting antibacterial and anticoagulant material, comprising the following steps:

[0038] S1. Preparation of Cu-MOFs coating

[0039] A Cu-MOFs coating is formed on the substrate, and the Cu-MOFs nanoparticles containing amino groups can be used to introduce Cu-MOFs onto the substrate with functional groups such as quinone groups, epoxy groups, and isocyanate groups.

[0040] In the actual operation process, the preparation method of Cu-MOFs coating includes: mixing Cu-MOFs nanoparticles containing amino groups with a solution with reactive groups to obtain the coating solution, and then by dip coating or spin coating A Cu-MOFs coating is formed on the surface of the substrate; wherein, the reactive group is selected from at least one of quinone group, epoxy group and diisocyanate. The reactive group can be one kind or several kinds, which is not limited here.

[0041] Specifically, Cu-MOFs nan...

Embodiment 1

[0060] This embodiment provides a method for preparing a long-acting antibacterial and anticoagulant material, and the specific steps are as follows:

[0061] (1) Cut TPU into squares of 1cm×1cm, ultrasonically clean them with ethanol and distilled water for 10min, and dry them at 50°C for later use. Ultrasonic dispersion of the synthesized Cu-MOFs nanoparticles in 2 mg / mL Tris (pH=8.5) solution of dopamine with quinone groups to form a mixed solution of Cu-MOFs nanoparticles with a concentration of 4.5 mg / mL; the sample was placed in the configuration In a good mixed solution of Cu-MOFs / dopamine, it was deposited at 37°C for 12 hours and then ultrasonically cleaned; three layers were deposited repeatedly to obtain a mixed coating of polydopamine and Cu-MOFs nanoparticles, which was denoted as Cu-MOFs-PDA.

[0062] (2) Transfer the Cu-MOFs-PDA sample to the high-pressure reactor and pump the vacuum to 0.1MPa for 60min, then close the vacuum valve, open the nitric oxide main va...

Embodiment 2

[0064] This embodiment provides a method for preparing a long-acting antibacterial and anticoagulant material, and the specific steps are as follows:

[0065] (1) Cut TPU into squares of 1cm×1cm, ultrasonically clean them with ethanol and distilled water for 10min, and dry them at 50°C for later use. The synthesized Cu-MOFs nanoparticles were ultrasonically dispersed in the medical coating solution with epoxy groups and diisocyanates to form a mixed solution with a concentration of Cu-MOFs nanoparticles of 4.5 mg / mL. Then use a spin coater to spin-coat 10 layers on the surface of the base material. During each layer of spin-coating, the control speed is 800r / min, and the spin-coating time is 40s to obtain a mixed coating of medical coating and Cu-MOFs nanoparticles. For Cu-MOFs@PC.

[0066] (2) Transfer the Cu-MOFs@PC sample obtained by spin coating to a high-pressure reactor and pump the vacuum to 0.1 MPa for 60 minutes, then close the vacuum valve, open the main valve of ni...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
concentrationaaaaaaaaaa
Login to view more

Abstract

The invention discloses a long-acting antibacterial and anticoagulant material as well as a preparation method and application thereof, and relates to the technical field of medical materials. The long-acting antibacterial and anticoagulant material comprises a base material, the base material is coated with a Cu-MOFs coating, and nitric oxide is loaded in the Cu-MOFs coating. According to the preparation method, nitric oxide is loaded in a Cu-MOFs coating, so that the Cu-MOFs coating loaded with NO gas is prepared. NO loaded in the Cu-MOFs coating and Cu < 2 + > can be synergistically released in a safe physiological range of a human body, so that the efficient antibacterial effect of the medical material at the initial stage of being implanted into the human body is realized; the Cu-MOFs coating can catalyze an endogenous NO donor to release NO in situ, so that the release time of NO on the surface of the material is greatly prolonged. In addition, the long-acting and stable NO release of the medical material can be realized by virtue of the behavior of releasing a large amount of NO loaded in the early stage and sequentially releasing the NO donor catalyzed by the Cu (II) in the later stage, and the release period can reach 30 days.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a long-acting antibacterial and anticoagulant material, its preparation method and application. Background technique [0002] The clinical application of implant materials is very extensive, and implant materials play an important role in the treatment of many diseases. However, the implant material can cause blood clots and infection problems, which have become the most common complications in hospitals. With the widespread use of medical implant materials in patients with long-term infusion, blood transfusion, hemodialysis, blood collection, parenteral nutrition, plasma exchange and emergency treatment, the related infection, thrombosis and occlusion caused by it are also a problem for the treatment of patients. There were more serious effects, especially associated infection and thrombosis of the implant material. One of the sources of these infections and thrombus...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61L33/02A61L33/00A61L33/06A61L31/08A61L31/10A61L31/14A61L31/16
CPCA61L33/0041A61L33/0076A61L33/022A61L33/027A61L33/068A61L31/088A61L31/10A61L31/14A61L31/16A61L2300/404A61L2300/42A61L2400/12A61L2400/18A61L2420/02A61L2420/04A61L2300/10A61L2300/102A61L2300/602A61L2300/606C08L87/00
Inventor 陈俊英柯贤兰章建文翁亚军黄茂桃袁娅婷
Owner SOUTHWEST JIAOTONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap