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Application of aristolochic acid IVa in preparation of antihistamine or pneumonia treatment drugs

A technology of aristolochic acid and antihistamine, which is applied in anti-inflammatory agents, drug combinations, antipyretics, etc., can solve the undiscovered problems of aristolochic acid IVa, etc., achieve significant antihistamine effect and reduce tissue inflammation Exudation, the effect of reducing the amount of inflammation exudation

Active Publication Date: 2022-05-13
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After searching, no relevant experimental research on the preparation of antihistamine drugs or drugs for the treatment of pneumonia has been found so far.

Method used

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  • Application of aristolochic acid IVa in preparation of antihistamine or pneumonia treatment drugs
  • Application of aristolochic acid IVa in preparation of antihistamine or pneumonia treatment drugs
  • Application of aristolochic acid IVa in preparation of antihistamine or pneumonia treatment drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1: Effects of AA-IVa on Histamine-Induced Increased Vascular Permeability in Mice

[0036] 1. Test reagent

[0037] Evans blue (EB): Sinopharm Chemical Reagent Co., Ltd., batch number: 20180125; 0.9% sodium chloride injection: Chenxin Pharmaceutical Co., Ltd., batch number: 1801022725; Formamide: Tianjin Damao Chemical Reagent Factory, batch number : 20180416; histamine: Sinopharm Chemical Reagent Co., Ltd., batch number 20160711; AA-IVa (molecular formula: C 17 h 11 NO 8 , with a molecular weight of 293.27), derived from the traditional Chinese medicine Asarum, purchased from Beijing Saibaicao Technology Co., Ltd., batch number: SH18121005.

[0038] 2. Test materials

[0039] Mouse strain: ICR; sex: male.

[0040] Animal weight: 23-25g animals were selected, and the test substance was administered after 1 day of adaptive feeding. Source: Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. Animal requirements: no special pathogenic bacteria.

...

Embodiment 2

[0090] Example 2: AA-IVa alleviates histamine-induced pneumonia

[0091] 1. Experimental method

[0092] (1) The establishment of the model, animal grouping and administration are the same as in Example 1.

[0093] (2) Pathological examination of lung tissue: After the mice were sacrificed by devertebralization, they were dissected and the lung tissue was taken out. The lung tissue was fixed with 10% neutral formalin for later use. The submitted tissue was fully fixed with formaldehyde, dehydrated with ethanol step by step, transparent in xylene, embedded in paraffin, and routinely prepared 3 μm paraffin sections. Stained with HE, Masson, PAS respectively, and optical microscope (DP71 type, OLYMPUS, magnified 400 times) to check the tissue inflammatory exudation.

[0094] 2. Experimental results

[0095] Lung histopathological results showed: figure 2 A is the normal control group, showing normal structure of alveoli and trachea in lung tissue. figure 2 B is the model ...

Embodiment 3

[0103] Embodiment 3 toxicity test

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Abstract

The invention discloses application of aristolochic acid IVa in preparation of antihistamine or pneumonia treatment drugs, and belongs to the technical field of new application of medicines, the aristolochic acid IVa and pharmaceutically acceptable salts thereof are used as active components, on one hand, the antihistamine effect can be achieved by inhibiting vascular permeability, and on the other hand, the effect of treating pneumonia can be achieved; on the other hand, pneumonia can be treated by reducing tissue inflammation exudation amount. Compared with the prior art, the active ingredient aristolochic acid IVa has no obvious toxicity and good safety, and a new direction is provided for application of the traditional Chinese medicine containing aristolochic acid.

Description

technical field [0001] The invention belongs to the technical field of new uses of medicine, and specifically relates to the application of aristolochic acid IVa in the preparation of antihistamine drugs or drugs for treating pneumonia. Background technique [0002] Histamine is an allergic and inflammatory mediator. Many tissues, especially mast cells of the skin, lung, and intestinal mucosa, contain large amounts of histamine. Histamine is released in response to tissue damage or inflammatory and allergic reactions. Histamine has a strong vasodilation effect, and can increase the permeability of capillaries and venules, allowing plasma to leak into tissues, leading to local tissue edema. Many clinical diseases are related to the release of histamine, such as skin allergies, rhinitis, asthma, anaphylactic shock, etc. [0003] Pneumonia is caused by a variety of pathogens (such as viruses, bacteria, fungi, parasites), radiation, chemicals, allergies and other factors. Ty...

Claims

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Application Information

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IPC IPC(8): A61K31/36A61P11/00A61P37/08A61P29/00
CPCA61K31/36A61P11/00A61P37/08A61P29/00Y02A50/30
Inventor 梁爱华王连嵋
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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