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Application of aristolochic acid iva in the preparation of antihistamine or medicine for treating pneumonia

A technology of aristolochic acid and antihistamine, which is applied in anti-inflammatory agents, drug combinations, antipyretics, etc., can solve the undiscovered problems of aristolochic acid IVa, etc., achieve significant antihistamine effect and reduce tissue inflammation Exudation, the effect of reducing the amount of inflammation exudation

Active Publication Date: 2022-07-05
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After searching, no relevant experimental research on the preparation of antihistamine drugs or drugs for the treatment of pneumonia has been found so far.

Method used

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  • Application of aristolochic acid iva in the preparation of antihistamine or medicine for treating pneumonia
  • Application of aristolochic acid iva in the preparation of antihistamine or medicine for treating pneumonia
  • Application of aristolochic acid iva in the preparation of antihistamine or medicine for treating pneumonia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1: The effect of AA-IVa on histamine-induced increase in vascular permeability in mice

[0036] 1. Test reagents

[0037] Evans Blue (EB): Sinopharm Chemical Reagent Co., Ltd., batch number: 20180125; 0.9% sodium chloride injection: Chenxin Pharmaceutical Co., Ltd., batch number: 1801022725; Formamide: Tianjin Damao Chemical Reagent Factory, batch number : 20180416; Histamine: Sinopharm Chemical Reagent Co., Ltd., batch number 20160711; AA-IVa (molecular formula: C 17 H 11 NO 8 , the molecular weight is 293.27), derived from traditional Chinese medicine Asarum, purchased from Beijing Saibaicao Technology Co., Ltd., batch number: SH18121005.

[0038] 2. Test material

[0039] Mouse strain: ICR; sex: male.

[0040] Animal body weight: 23-25g animals were selected, and the test substance was administered after 1 day of adaptive feeding. Source: Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd. Animal requirements: no special pathogenic bacteria. ...

Embodiment 2

[0090] Example 2: AA-IVa alleviates histamine-induced pneumonia

[0091] 1. Experimental method

[0092] (1) Model establishment, animal grouping and administration are the same as in Example 1.

[0093] (2) Pathological examination of lung tissue: After the mice were killed by dislocation, the lung tissue was removed by dissection. Lung tissue was fixed with 10% neutral formalin. The tissues submitted for inspection were fully fixed in formaldehyde, dehydrated in ethanol, transparent in xylene, embedded in paraffin, and routinely prepared 3 μm paraffin sections. Stained with HE, Masson and PAS, respectively, and light microscope (DP71 type, OLYMPUS, magnification 400 times) was used to examine the tissue inflammation and exudation.

[0094] 2. Experimental results

[0095] The pathological results of lung tissue showed: figure 2 A is the normal control group, showing that the alveoli and trachea of ​​the lung tissue are normal. figure 2 B is the model control group, s...

Embodiment 3

[0103] Example 3 Toxicity Test

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Abstract

The invention discloses the application of aristolochic acid IVa in the preparation of antihistamine or medicine for treating pneumonia, belonging to the technical field of new medical uses. The aristolochic acid IVa and pharmaceutically acceptable salts thereof are used as active components, On the one hand, it can achieve antihistamine effect by inhibiting vascular permeability, and on the other hand, it can treat pneumonia by reducing the amount of tissue inflammatory exudation. Compared with the prior art, the active ingredient aristolochic acid IVa of the present invention has no obvious toxicity and good safety, and provides a new direction for the application of aristolochic acid-containing traditional Chinese medicine.

Description

technical field [0001] The invention belongs to the technical field of new medical uses, in particular to the application of aristolochic acid IVa in the preparation of antihistamine drugs or drugs for treating pneumonia. Background technique [0002] Histamine is an allergy and inflammatory mediator. Many tissues, especially the mast cells of the skin, lung, and intestinal mucosa contain large amounts of histamine. Histamine is released when tissue is damaged or when inflammation and allergic reactions occur. Histamine has a strong vasodilatory effect, and can increase the permeability of the capillaries and venules, and the plasma leaks into the tissue, resulting in local tissue edema. Many clinical diseases are related to histamine release, such as skin allergy, rhinitis, asthma, anaphylactic shock, etc. [0003] Pneumonia is caused by a variety of pathogens (such as viruses, bacteria, fungi, parasites), radiation, chemicals, allergies and other factors. Typical pneum...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/36A61P11/00A61P37/08A61P29/00
CPCA61K31/36A61P11/00A61P37/08A61P29/00Y02A50/30
Inventor 梁爱华王连嵋
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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