Preparation method of ZIF-8-loaded Janus electrospun fibrous membrane

A ZIF-8, electrospinning fiber technology, used in fiber processing, electrospinning, fiber chemical characteristics, etc.
CN114470342AInactive Publication Date: 2022-05-13JILIN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JILIN UNIV
Publication Date
2022-05-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a ZIF-8-loaded Janus electrospun fibrous membrane as well as a preparation method and application thereof, and belongs to the technical field of dental restoration materials. The method comprises the following steps: mixing ZIF-8 with a polyvinylpyrrolidone solution, mixing the mixed solution with a poly (epsilon-caprolactone) solution in an isovolumetric manner, and obtaining the Janus electrospun fiber membrane by utilizing a phase separation phenomenon between the polyvinylpyrrolidone solution and the poly (epsilon-caprolactone) solution through a single-shaft electrospinning technology. The invention further provides the Janus electrospun fiber membrane of the ZIF-8, which is obtained by the preparation method. According to the Janus electrospun fibrous membrane, slow release of ZIF-8 is achieved, proliferation of bacteria can be inhibited, osteogenic differentiation of rat bone marrow mesenchymal stem cells is effectively promoted, and the Janus electrospun fibrous membrane has a good treatment effect on periodontal defects caused by periodontitis.
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Description

technical field

[0001] The invention belongs to the technical field of dental restoration materials, and in particular relates to a ZIF-8-loaded multifunctional Janus electrospun fiber membrane and its preparation method and application. Background technique

[0002] Periodontitis is a chronic inflammatory disease caused by plaque microorganisms, and its serious consequence is progressive alveolar bone loss, which eventually leads to loosening, displacement and even loss of teeth. Among the existing treatment methods for periodontitis, guided tissue regeneration (GTR) is an important method to restore periodontal supporting tissue and new attachments. The principle is to use the GTR membrane as a physical barrier to prevent the growth of fibroblasts and epithelial cells. Into the periodontal ligament cells and osteoblasts to create enough space to rebuild the damaged periodontal tissue. However, overall treatment outcomes for GTR were suboptimal. First, after GTR surgery, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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