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Preparation method of ZIF-8-loaded Janus electrospun fibrous membrane

A ZIF-8, electrospinning fiber technology, used in fiber processing, electrospinning, fiber chemical characteristics, etc.

Inactive Publication Date: 2022-05-13
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the shortcoming of existing GTR membrane only as physical barrier membrane, and provide a kind of preparation method of Janus electrospun fiber membrane loaded with ZIF-8

Method used

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  • Preparation method of ZIF-8-loaded Janus electrospun fibrous membrane
  • Preparation method of ZIF-8-loaded Janus electrospun fibrous membrane
  • Preparation method of ZIF-8-loaded Janus electrospun fibrous membrane

Examples

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Effect test

preparation example Construction

[0028] The present invention at first provides a kind of preparation method of the Janus electrospun fiber membrane of loading ZIF-8, and this method comprises:

[0029] Step 1: After dissolving PVP in the solvent and stirring overnight, mix ZIF-8 with the PVP solution;

[0030] Step 2: Dissolve PCL in the mixed solvent and stir overnight;

[0031] Step 3: Mix the PVP solution containing ZIF-8 and the PCL solution in equal volumes, and after phase separation occurs, prepare a Janus electrospun fiber membrane loaded with ZIF-8 by uniaxial electrospinning technology.

[0032] According to the present invention, PVP is first dissolved in N-N dimethylformamide, PCL is dissolved in chloroform and N-N dimethylformamide (4:1) mixed solution, the concentration of said PVP is preferably 14wt%, The concentration of PCL is preferably 14wt%, and then ZIF-8 is dissolved in the PVP solution, the concentration of ZIF-8 is preferably 14wt%, and an equal volume of PCL solution is mixed with t...

Embodiment 1

[0035] The preparation of embodiment 1PP JNF

[0036] PVP is dissolved in N-N dimethylformamide, PCL is dissolved in chloroform and N-N dimethylformamide (4:1) mixed solution, the concentration of PVP is preferably 14wt%, the concentration of described PCL is preferably 14wt%, and then mix equal volumes of PVP and PCL solutions, and after phase separation occurs in the solution, uniaxial electrospinning technology is used, the applied voltage is 13-15kV, the receiving distance is 18cm, and the flow rate is 1mL / h to prepare PP JNF.

[0037] The PP JNF obtained in Example 1 was observed using a scanning electron microscope to observe the morphology of the sample, figure 1 The microstructure of PPJNF is shown. The diameter of PP JNF fibers is uniform, with an average diameter of 797±138nm. After dissolving in water, the groove structure of the fibers can be observed, which is caused by the dissolution of PVP.

Embodiment 2

[0038] The preparation of embodiment 2PPZ JNF

[0039] PVP is dissolved in N-N dimethylformamide, PCL is dissolved in chloroform and N-N dimethylformamide (4:1) mixed solution, the concentration of described PVP is preferably 14wt%, the concentration of PCL is preferably 14wt%, and then ZIF-8 is dissolved in the PVP solution, and the concentration of ZIF-8 is preferably 14wt%, and an equal volume of PCL solution is mixed with the PVP solution loaded with ZIF-8, and after phase separation occurs in the solution, a single Shaft electrospinning technology, the applied voltage is 13-15kV, the receiving distance is 18cm, and the flow rate is 1mL / h to prepare PPZ JNF.

[0040] The PPZ JNF obtained in Example 2 was observed using a scanning electron microscope to observe the morphology of the sample, figure 2 It shows the microstructure of PPZ JNF. The fiber diameter of PPZ JNF is not uniform, and the swelling part can be seen, which is caused by the incorporation of ZIF-8. After d...

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Abstract

The invention provides a ZIF-8-loaded Janus electrospun fibrous membrane as well as a preparation method and application thereof, and belongs to the technical field of dental restoration materials. The method comprises the following steps: mixing ZIF-8 with a polyvinylpyrrolidone solution, mixing the mixed solution with a poly (epsilon-caprolactone) solution in an isovolumetric manner, and obtaining the Janus electrospun fiber membrane by utilizing a phase separation phenomenon between the polyvinylpyrrolidone solution and the poly (epsilon-caprolactone) solution through a single-shaft electrospinning technology. The invention further provides the Janus electrospun fiber membrane of the ZIF-8, which is obtained by the preparation method. According to the Janus electrospun fibrous membrane, slow release of ZIF-8 is achieved, proliferation of bacteria can be inhibited, osteogenic differentiation of rat bone marrow mesenchymal stem cells is effectively promoted, and the Janus electrospun fibrous membrane has a good treatment effect on periodontal defects caused by periodontitis.

Description

technical field [0001] The invention belongs to the technical field of dental restoration materials, and in particular relates to a ZIF-8-loaded multifunctional Janus electrospun fiber membrane and its preparation method and application. Background technique [0002] Periodontitis is a chronic inflammatory disease caused by plaque microorganisms, and its serious consequence is progressive alveolar bone loss, which eventually leads to loosening, displacement and even loss of teeth. Among the existing treatment methods for periodontitis, guided tissue regeneration (GTR) is an important method to restore periodontal supporting tissue and new attachments. The principle is to use the GTR membrane as a physical barrier to prevent the growth of fibroblasts and epithelial cells. Into the periodontal ligament cells and osteoblasts to create enough space to rebuild the damaged periodontal tissue. However, overall treatment outcomes for GTR were suboptimal. First, after GTR surgery, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/06A61L31/16D01D5/00D01F1/10D01F6/92D04H1/435D04H1/728
CPCA61L31/048A61L31/16A61L31/06D01F6/92D01F1/10D04H1/728D04H1/435D01D5/003A61L2300/216A61L2300/604A61L2300/404A61L2300/412D10B2401/13D10B2509/00C08L39/06C08L67/04
Inventor 刘国民孙茂蕾罗云纲程志强刘昀贾汶沅焦琨姜孔昭王少如刘丽萍代智慧杨语恒
Owner JILIN UNIV
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