Polyphenol nano-strip, preparation method thereof and application of polyphenol nano-strip in radiation protection

A technology of nano-strips and polyphenol compounds, applied in the field of radiation protection, can solve the problems of complex composition of nano-materials, difficulty in fully utilizing polyphenols, complex and cumbersome material synthesis, etc., to achieve rich hydrophilic groups and promote the function of polyphenols Effects that play up and simplify the compositing process

Pending Publication Date: 2022-06-03
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, the disadvantage of the nanocarrier method is that nanocarriers such as metal-organic framework materials, micelles, and polymer nanoparticles need to be synthesized first, and then polyphenols are loaded in the carrier, which makes the synthesis of materials complicated and time-consuming; Moreover, the loading amount of polyphenols in nanocarriers is limited, and it is not easy to give full play to the functions of polyphenols.
The multi-component self-assembly method will introduce other components and lead to complex composition of nanomaterials, which may also bring higher toxicity and side effects

Method used

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  • Polyphenol nano-strip, preparation method thereof and application of polyphenol nano-strip in radiation protection
  • Polyphenol nano-strip, preparation method thereof and application of polyphenol nano-strip in radiation protection
  • Polyphenol nano-strip, preparation method thereof and application of polyphenol nano-strip in radiation protection

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preparation example Construction

[0032] The invention provides a preparation method of a polyphenol nano-strip, comprising the following steps:

[0033] The polyphenolic compound solution and the poor solvent are mixed for aggregation and assembly to obtain polyphenol nanoribbons.

[0034] In the present invention, unless otherwise specified, the required preparation raw materials are all commercially available products well known to those skilled in the art.

[0035] The present invention mixes the polyphenolic compound solution and the poor solvent. In the present invention, the polyphenolic compounds in the polyphenolic compound solution preferably include quercetin, resveratrol, luteolin, apigenin, kaempferol, catechin, naringenin, genistein Flavonoids, shikonin or curcumin.

[0036] In the present invention, the solvent used in the polyphenolic compound solution is preferably dimethyl sulfoxide or ethanol; the ratio of the molar amount of the polyphenolic compound to the volume of the solvent in the po...

Embodiment 1

[0046] 2.5 mL of dimethyl sulfoxide solution containing 0.04 mmol of quercetin was rapidly added dropwise to 12.5 mL of water under stirring conditions, and the stirring was continued for 1 h at room temperature. The resulting mixture was centrifuged at 8000 rpm for 5 minutes, and the supernatant was removed. The precipitate was redispersed in 10 mL of water, and the centrifugation-dispersion process was repeated twice to obtain an aqueous solution of quercetin nanoribbons.

Embodiment 2

[0048] 12.5 mL of water was rapidly added dropwise to 2.5 mL of dimethyl sulfoxide solution containing 0.04 mmol of quercetin under stirring conditions, and stirring was continued for 1 h at room temperature. The resulting mixture was centrifuged at 8000 rpm for 5 minutes, and the supernatant was removed. The obtained precipitate was redispersed in 10 mL of water, and the centrifugation-dispersion process was repeated twice to obtain an aqueous solution of quercetin nanoribbons.

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Abstract

The invention provides a polyphenol nano strip, a preparation method thereof and application of the polyphenol nano strip in radiation protection, and belongs to the technical field of radiation protection. According to the preparation method, only polyphenol is used as a unique reaction raw material to synthesize the nano material, and the prepared polyphenol nano strip is only composed of the polyphenol and equivalently contains 100% of polyphenol, so that compared with a polyphenol monomer, the polyphenol nano strip can effectively improve the water solubility and radiation protection effect of the polyphenol. Compared with a nano-carrier method and a multi-component self-assembly method, the method disclosed by the invention has the advantages that the polyphenol nano-strip can be obtained only through a simple one-step reaction, so that the synthesis process of the material is simplified; no synthetic carrier is needed, and no load rate problem exists; the use of other components (metal ions or other organic matters are not contained) is avoided, the method is safe and effective, and possible toxicity and side effects are avoided while the function exertion of polyphenol is promoted.

Description

technical field [0001] The invention relates to the technical field of radiation protection, in particular to a polyphenol nano-strip, a preparation method thereof, and an application in radiation protection. Background technique [0002] Since the discovery of X-ray, human beings have begun to understand, study and utilize ionizing radiation. Radionuclides widely present in soil, food, water and air can continuously release ionizing radiation through decay, and ionizing radiation also exists in rays from outside the universe. There is also a lot of ionizing radiation in areas such as cancer treatment, medical diagnosis, security inspection, industrial non-destructive testing, and the nuclear industry. All these natural or artificial ionizing radiations pose a serious threat to human life and health. However, the existing radioprotective drugs such as amifostine and palivamine have shortcomings such as high toxicity, narrow application range, poor stability and short circu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/352A61K31/05A61K31/353A61K31/122A61K31/12A61P39/00
CPCA61K9/0087A61K9/0053A61K31/352A61K31/05A61K31/353A61K31/122A61K31/12A61P39/00
Inventor 刘轶董泽坤王泽孙伟杨柏张皓
Owner JILIN UNIV
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