Preparation method and application of double-electric-field driving sensor
A technology for driving sensors and dual electric fields, which is applied to instruments, scientific instruments, and electrochemical variables of materials. It can solve problems such as low sensitivity, complex manufacturing, and slow response speed, and achieve high specific surface area, overcome interference, and excellent conductivity. Effect
Active Publication Date: 2022-06-24
JIANGSU UNIV
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Problems solved by technology
[0004] Aiming at the problems of traditional electrochemical immunosensor detection of pesticide residues such as complex production, low sensitivity, and slow response speed, the present invention discloses a preparation method of a dual electric field driven sensor and its application, combined with external complementary double electric field drive and specificity of antigen-antibody reaction, rapid determination of pesticide residues in natural samples
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Embodiment 1
[0049] Taking the detection of methyl parathion in an actual sample as an example, a preparation method and application of a dual electric field driven sensor, including the following steps:
[0050] Step 1: Fabrication of a flexible printed substrate: use computer graphics software to design the shape of the circuit; cut the flexible polyimide substrate 1 (length: 3 cm, width: 1.5 cm); set a circuit at one end of the flexible polyimide substrate 1 The 5 conductive vias connected to 2 and marked as N 1 , N 2 , N 3 , N 4 , N 5 ; Spray a layer of copper film 3 with a uniform thickness of 15 μm on the surface of the flexible polyimide substrate 1; use photolithography technology to coat the photoresist phenolic resin on the copper film 3 according to the pre-designed circuit shape; The photoresist-coated flexible polyimide substrate 1 is placed under ultraviolet light for exposure; the exposed flexible polyimide substrate 1 is developed with 0.1 g / mL sodium carbonate; after d...
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Abstract
The invention belongs to the field of pesticide residue detection by an electrochemical sensor, and particularly relates to a preparation method and application of a double-electric-field driving sensor. Firstly, a flexible printing substrate is prepared, and double-electric-field distribution can be effectively adjusted according to a plurality of electrode arrays on a flexible printing electrode; the sensor is endowed with good biocompatibility, catalytic performance and conductivity by modifying RGO and gold nanoparticles on the surface of the electrode. Meanwhile, pesticide antibodies are introduced to selectively recognize pesticide molecules, double-electric-field driving is applied, microflow and particles in a solution can move directionally, an analyte can quickly flow to the surface of the biosensor, the binding efficiency of the analyte and a probe on the surface of the sensor is improved, and the reaction time is shortened. The complementary double-electric-field mode can effectively prevent bubbles from being generated on the surface of the sensor due to overlarge voltage, so that a more effective electric field enhancement strategy is established, and the sensitivity and the detection efficiency of the sensor are improved. The rapid and selective detection on the pesticide residues in a natural sample is realized.
Description
technical field [0001] The invention belongs to the field of pesticide residue detection by electrochemical sensors, and in particular relates to a preparation method and application of a dual electric field driven sensor. Background technique [0002] Pesticides are substances or mixtures used to prevent, control and reduce harmful organisms. With the development of modern agriculture, the application of pesticides has become one of the indispensable links in crop production. However, the overuse of pesticides can lead to groundwater and food contamination, with severe impacts on humans and animals. Long-term human exposure to pesticides can lead to harmful health effects such as neurotoxicity, genotoxicity, mutagenicity and carcinogenicity. Although various laboratory-based analytical methods such as gas chromatography, high performance liquid chromatography, mass spectrometry, and ELISA methods have been widely used, they all have their own disadvantages, such as the use...
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IPC IPC(8): G01N27/327G01N27/48
CPCG01N27/327G01N27/48
Inventor 张文苏小雨袁磊周璇胡矩涛邹小波
Owner JIANGSU UNIV