Halloysite-melanin surface codeposition hemostatic bandage and preparation method thereof

A technology of co-deposition and melanin, applied in tourniquets, bandages, medical science, etc., can solve the problems of limiting allergic reactions in the body, increasing platelet adhesion, accelerating blood coagulation process, etc., to achieve synergistic hemostatic performance, promote adhesion aggregation, and accelerate blood coagulation process Effect

Pending Publication Date: 2022-07-12
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The porous structure and amino groups of chitosan hemostatic material can increase the adhesion of platelets and promote the aggregation of blood components such as red blood cells to form thrombus at the wound site (Du, X., Liu, Y., Yan, H., et al .Anti-infective and pro-coagulant chitosan-based hydrogel tissue adhesive for sutureless wound closure.Biomacromolecules 2020,21,1243-1253), however, its refractory degradation and easy triggering of allergic reactions in the body limit its application
Mesoporous silica can promote the activation of coagulation factor XII, accelerate coagulation cascade reaction and promote coagulation (Wang, C., Zhou, H., Niu, H., et al. Tannic acid-loaded mesoporous silica for rapid hemostasis and antibacterial activity , Biomaterials Science.2018, 6, 3318-3331), but the potential metabolic toxicity and the difficulty of cleaning powder particles in the wound limit its application
Zeolite-based hemostatic materials can absorb moisture in the blood at the wound and promote the aggregation of platelets and coagulation factors. At the same time, the calcium ions released by it can activate platelets and accelerate the coagulation process (Liang, Y., Xu, C., LiuF., et al. al.Eliminating heat injury of zeolite in hemostasis via thermalconductivity of graphene sponge.ACS Applied Materials Interfaces.2019,11,23848-23857), however, its severe exothermic effect may cause secondary damage to the wound

Method used

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  • Halloysite-melanin surface codeposition hemostatic bandage and preparation method thereof
  • Halloysite-melanin surface codeposition hemostatic bandage and preparation method thereof
  • Halloysite-melanin surface codeposition hemostatic bandage and preparation method thereof

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Embodiment 1

[0026] Take 10 g of halloysite nanotube raw ore, dissolve it in 800 mL of deionized water (mass ratio 1:80), stir magnetically for 8 hours, and perform suction filtration. The halloysite nanotubes obtained by suction filtration were resuspended in 100 mL of deionized water, allowed to settle naturally for 10 min, and the supernatant was collected and centrifuged at 8000 rpm. The precipitate obtained by centrifugation was dried in an oven at 60° C. for 12 hours to obtain halloysite nanotubes with particle sizes ranging from 400 to 600 nm.

[0027] Take commercially purchased feathers or hair strands, wash 3 times with acetone, 3 times with deionized water, and chop. The obtained feathers or hair strands were added to 40 mL of phosphate buffer (pH=6.8), 0.4 g of dithiothreitol (DTT) was added, and the mixture was uniformly mixed. 2 Under the atmosphere, shake at 37 °C for 12 h. Add 1 mL of 20 mg / mL proteinase K and 0.2 g of DTT, and continue to shake for 12 h. Centrifuge at 8...

Embodiment 2

[0030] Take 30 g of halloysite nanotube raw ore, dissolve it in 800 mL of deionized water (mass ratio 3:80), stir magnetically for 8 hours, and perform suction filtration. The halloysite nanotubes obtained by suction filtration were resuspended in 300 mL of deionized water, allowed to settle naturally for 10 min, and the supernatant was collected and centrifuged at 8000 rpm. The precipitate obtained by centrifugation was dried in an oven at 80° C. for 10 h to obtain halloysite nanotubes with particle sizes ranging from 400 to 600 nm.

[0031] Take commercially purchased feathers or hair strands, wash 3 times with acetone, 3 times with deionized water, and chop. The obtained feathers or hair strands were added to 40 mL of phosphate buffer (pH=6.8), 0.4 g of dithiothreitol (DTT) was added, and the mixture was uniformly mixed. 2 Under the atmosphere, shake at 37 °C for 12 h. Add 1 mL of 20 mg / mL proteinase K and 0.2 g of DTT, and continue to shake for 12 h. Centrifuge at 8000 ...

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Abstract

The invention discloses a halloysite-melanin surface co-deposition hemostatic bandage and a preparation method thereof. The halloysite-melanin surface co-deposition hemostatic bandage is formed by sequentially co-depositing natural melanin particles and halloysite nanotubes on the surface of a hemostatic bandage base material. According to the halloysite-melanin surface co-deposition hemostasis bandage, the natural melanin particles and the halloysite nanotubes are co-deposited on the surface of the hemostasis bandage base material in sequence only through simple dipping, the halloysite-melanin surface co-deposition hemostasis bandage is prepared, the preparation process is simple, the cost is low, and the application range is wide. The halloysite nanotubes and the natural melanin particles have synergistic efficient hemostatic performance, and have good biological safety.

Description

technical field [0001] The invention belongs to the technical field of functional hemostatic materials, in particular to a halloysite-melanin surface co-deposition hemostatic bandage and a preparation method thereof. Background technique [0002] The development and utilization of safe and efficient hemostatic materials is the key to the success of pre-hospital emergency care. At present, the main hemostatic components of common hemostatic materials are chitosan, silica, zeolite, etc. The porous structure and amino groups of chitosan hemostatic material can increase the adhesion of platelets and promote the aggregation of blood components such as red blood cells to form thrombus at the wound site (Du, X., Liu, Y., Yan, H., et al. .Anti-infective and pro-coagulant chitosan-based hydrogel tissueadhesive for sutureless wound closure. Biomacromolecules 2020, 21, 1243-1253), however, its refractory degradation and easy inducing allergic reactions in vivo limit its application. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/132A61F13/00
CPCA61B17/132A61F13/00987A61F13/00012A61F13/00991A61F13/00063
Inventor 张毅黄宗旺
Owner CENT SOUTH UNIV
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