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Oil suspension of sulforaphane and preparation method thereof

A technology of sulforaphane and oil suspension, which is applied in the direction of liquid transportation, emulsion transportation, food forming, etc. It can solve the problems of inconvenient use of dripping pills and easy decomposition of sulforaphane, so as to improve absorption speed and bioavailability The effect of high degree, simple process and easy industrialization

Active Publication Date: 2022-07-15
PIONEER HERB IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, patent CN201410009814.1 reports the method of preparing capsules of sulforaphane, but vacuum concentration at 60-70°C is used in the preparation process, sulforaphane is easy to decompose, and only 4°C can be stored for a long time
Patent CN106619553B discloses a preparation method of sulforaphane microemulsion quick-release drop pills, but the drop pills are not very convenient to use

Method used

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preparation example Construction

[0023] The invention provides a preparation method of an oil suspension of sulforaphane, comprising the following steps:

[0024] (1) prepare sulforaphane polar phase: mix sulforaphane, citric acid, glycerol, polyglycerol ricinole ester to prepare polar phase;

[0025] (2) prepare oil phase: mix β-carotene and edible oil to form oil phase;

[0026] (3) The polar phase and the oil phase are mixed to prepare an oil suspension of sulforaphane. The sulforaphane oil suspension has good stability.

[0027] In step (1), the proportion of each substance in the polar phase is: the mass ratio of sulforaphane, citric acid, glycerol, polyglycerol ricinole ester is 1: (0.02~0.1): (2~4): (6-15). The method for preparing the polar phase of sulforaphane in step (1) is as follows: mixing sulforaphane, citric acid, glycerol, and polyglycerol ricinole ester, and homogenizing 2-5 times with a high-pressure homogenizer to form a polar phase. The homogenization conditions of the high pressure h...

Embodiment 1

[0032] (1) Mix 1g of sulforaphane (content is 95%), 0.05g of citric acid, 3g of glycerol and 10g of polyglycerol ricinole ester, and homogenize 2-5 times with a high pressure homogenizer, at a rotational speed of 30000rpm, each time 150 seconds, with an interval of 5 minutes each time, to obtain the polar phase;

[0033] (2) 0.1g β-carotene, 60g corn oil were mixed, stirred to obtain oil phase;

[0034] (3) The polar phase is slowly added to the oil phase, and stirred to form a uniform sulforaphane emulsion, that is, an oil suspension of sulforaphane, and the sulforaphane oil suspension has good stability.

[0035] (4) The oil suspension of sulforaphane prepared in step (3) is placed in a sealed glass bottle at room temperature and protected from light, and the content of sulforaphane is reduced by less than 8% in 6 months.

[0036] Table 1 Sulforaphane Stability Data

[0037] time 0 January March June Sulforaphane content (%) 1.481 1.468 1.414 1.37...

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Abstract

The invention relates to an oil suspension of sulforaphane and a preparation method thereof. The preparation method comprises the following steps: firstly, mixing sulforaphane, citric acid, glycerol and polyglycerol polyricinoleate to prepare a polar phase; beta-carotene and edible oil are mixed to form an oil phase; and mixing the polar phase and the oil phase to prepare the sulforaphane oil suspension. Compared with the prior art, the method has the advantages that the process is simple and easy to implement, industrialization is easy, the whole process is low in price and small in investment, the obtained oil suspension product can be stored at normal temperature and is convenient to eat, and the absorption speed and bioavailability of the sulforaphane are improved. The invention can play a positive role in promoting the development of medicines and health-care products taking sulforaphane as a main active component.

Description

technical field [0001] The invention relates to a preparation method of a natural product, in particular to an oil suspension of sulforaphane and a preparation method thereof. Background technique [0002] Sulforaphane is an isothiocyanate derivative produced by glucoraphanin (a kind of glucosinolate) by myrosinase enzymatic hydrolysis or acid hydrolysis, with a relative molecular mass of 177.29 and a molecular formula of C 6 H 11 S 2 NO. Sulforaphane is a class of isothiocyanates with the strongest anti-cancer activity found in vegetables so far, and is currently recognized as one of the natural products with the best anti-cancer and anti-cancer effects. It can inhibit the expression of phase I enzymes and induce the expression of phase II enzymes, and has obvious blocking effect on liver cancer, breast cancer, lung cancer, esophagus cancer, prostate cancer, and gastric cancer, and sulforaphane also has the functions of protecting the skin, antibacterial, and improving t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/26A23L33/00A61P35/00A23P10/00
CPCA61K31/26A61K9/10A61P35/00A23L33/00A23P10/00A23V2002/00A23V2200/308Y02A50/30
Inventor 刘儒华刘锡建
Owner PIONEER HERB IND CO LTD
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