Disposable surgical implantation bone scaffold for treating bone infection

A technology of bone scaffolding and bone infection, applied in the medical field, can solve the problems of high cost, uncertain prognosis, and long course of treatment, and achieve the effects of improving curative effect, shortening the course of disease, and excellent mechanical properties

Pending Publication Date: 2022-07-29
GENERAL HOSPITAL OF NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that the current main methods for the treatment of infected bone ...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] A one-time surgically implanted bone scaffold for the treatment of bone infection, comprising a 3D bioceramic bone scaffold and antibacterial microspheres loaded with rifampicin / moxifloxacin dual antibiotics attached to the surface of the 3D bioceramic bone scaffold via nano-scale corn starch Layer, the 3D bioceramic bone scaffold is integrally formed by 3D printing, and the antibacterial microsphere layer containing rifampicin / moxifloxacin dual antibiotic is mixed with the nano-scale corn starch solution and deposited in 3D according to the patient's magnetic resonance test results. At the position corresponding to the bioceramic bone scaffold, the antibacterial microsphere layer is composed of a nanocarrier derived from egg yolk lipid and mesoporous silica to form a composite carrier, and the nanocarrier derived from egg yolk lipid and mesoporous silica are combined. The mass ratio is 6.5:1, the particle size of the composite carrier is 100 nanometers, the loading amou...

Embodiment 2

[0017] A one-time surgically implanted bone scaffold for the treatment of bone infection, comprising a 3D bioceramic bone scaffold and antibacterial microspheres loaded with rifampicin / moxifloxacin dual antibiotics attached to the surface of the 3D bioceramic bone scaffold via nano-scale corn starch Layer, the 3D bioceramic bone scaffold is integrally formed by 3D printing, and the antibacterial microsphere layer containing rifampicin / moxifloxacin dual antibiotic is mixed with the nano-scale corn starch solution and deposited in 3D according to the patient's magnetic resonance test results. At the position corresponding to the bioceramic bone scaffold, the antibacterial microsphere layer is composed of a nanocarrier derived from egg yolk lipid and mesoporous silica to form a composite carrier, and the nanocarrier derived from egg yolk lipid and mesoporous silica are combined. The mass ratio is 1.5:1, the particle size of the composite carrier is 500 nanometers, the loading amou...

Embodiment 3

[0019] A one-time surgically implanted bone scaffold for the treatment of bone infection, comprising a 3D bioceramic bone scaffold and antibacterial microspheres loaded with rifampicin / moxifloxacin dual antibiotics attached to the surface of the 3D bioceramic bone scaffold via nano-scale corn starch Layer, the 3D bioceramic bone scaffold is integrally formed by 3D printing, and the antibacterial microsphere layer containing rifampicin / moxifloxacin dual antibiotic is mixed with the nano-scale corn starch solution and deposited in 3D according to the patient's magnetic resonance test results. At the position corresponding to the bioceramic bone scaffold, the antibacterial microsphere layer is composed of a nanocarrier derived from egg yolk lipid and mesoporous silica to form a composite carrier, and the nanocarrier derived from egg yolk lipid and mesoporous silica are combined. The mass ratio is 4:1, the particle size of the composite carrier is 200 nanometers, the loading amount...

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Abstract

The invention relates to the technical field of medical treatment, in particular to a one-time surgical implantation bone scaffold for treating bone infection, which comprises a 3D biological ceramic bone scaffold and an antibacterial microsphere layer loaded with rifampicin/moxifloxacin duplex antibiotics and attached to the surface of the 3D biological ceramic bone scaffold through nanoscale corn starch, the antibacterial microsphere layer adopts a composite carrier formed by compounding a nanometer carrier derived from yolk lipid and mesoporous silica, and the particle size of the composite carrier is 100-1000 nanometers. According to the scheme, the bone scaffold which is excellent in mechanical property, capable of inducing bone repair, controllable in degradation and capable of slowly releasing antibiotics to treat infection is constructed, a new method and a new material are provided for clinical treatment of infectious bone defects, the disease course is shortened, and the curative effect is improved.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a one-time surgical implantation of a bone support for treating bone infection. Background technique [0002] At present, bone infection caused by trauma and implant surgery is still a common disease in orthopaedic clinic. Bone infection is often combined or later secondary to bone defect, and the coexistence of both brings great challenges to the treatment of this disease. How to shorten the course of the disease and improve the prognosis is a key issue for orthopaedic surgeons to solve. [0003] At present, there are three main treatment methods. One is repeated debridement, replacement of external fixation to stabilize fractures, antibiotic treatment with systemic antibiotics for 6-8 weeks, and sustained release of local bone cement antibiotics to treat infection. After infection treatment, implantation in the defect area Autologous bone and allogeneic bone, replacement of ...

Claims

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Application Information

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IPC IPC(8): A61L27/10A61L27/28A61L27/34A61L27/30A61L27/50A61L27/54A61L27/58B33Y70/10B33Y80/00
CPCA61L27/10A61L27/28A61L27/34A61L27/306A61L27/50A61L27/54A61L27/58B33Y70/10B33Y80/00A61L2300/602A61L2300/606A61L2300/406A61L2300/412A61L2400/12C08L3/02
Inventor 乔泽文
Owner GENERAL HOSPITAL OF NINGXIA MEDICAL UNIV
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