Albumin-based double-sided intravascular stent and preparation method thereof
A vascular stent, albumin technology, applied in the field of cardiovascular interventional therapy devices, can solve problems such as functional defects, and achieve the effect of reducing acute and chronic inflammation, reducing the incidence of late thrombosis, and treating cardiovascular diseases
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Embodiment 1
[0049] This embodiment provides a double-sided vascular stent, and the preparation steps are as follows:
[0050] S100, forming a coating on the inner surface of the stent
[0051] First add bovine serum albumin and ammonium persulfate to 50 mL of deionized water and mix and disperse to form solution A, so that the concentration of bovine serum albumin is 1 mg / mL and the concentration of ammonium persulfate is 1 mg / mL; The stent body was soaked in solution A for 6 hours, and the temperature was controlled at 37°C to form a coating on the inner surface of the stent.
[0052] S200, forming a coating on the outer surface of the stent
[0053] The stent body was washed 3 times with deionized water to remove substances adhering to the outer wall of the stent body. Then, polytrimethylene carbonate (Mn=500000) and caffeic acid were added to 8 mL of acetone, and stirred and dispersed at 50 rpm to form solution B, so that the concentration of polytrimethylene carbonate was 1 mg / mL, a...
Embodiment 2
[0056] This embodiment provides a double-sided vascular stent, and the preparation steps are as follows:
[0057] S100, forming a coating on the inner surface of the stent
[0058] First add bovine serum albumin and ammonium persulfate to 50 mL of deionized water and mix and disperse to form solution A, so that the concentration of bovine serum albumin is 1 mg / mL and the concentration of ammonium persulfate is 2 mg / mL; The stent body was soaked in solution A for 12 hours, and the temperature was controlled at 37°C. The color of the inner surface coating of the formed stent was yellow, and the connection temperature with the stent body was not easy to peel off.
[0059] S200, forming a coating on the outer surface of the stent
[0060] The stent body was washed 6 times with deionized water to remove substances adhering to the outer wall of the stent body. Then, polytrimethylene carbonate (Mn=500000) and caffeic acid were added to 8 mL of acetone, and stirred and dispersed at ...
Embodiment 3
[0063] This embodiment provides a double-sided vascular stent, and the preparation steps are as follows:
[0064] S100, forming a coating on the inner surface of the stent
[0065] First add bovine serum albumin and ammonium persulfate to 50 mL of deionized water and mix and disperse to form solution A, so that the concentration of bovine serum albumin is 1 mg / mL and the concentration of ammonium persulfate is 4 mg / mL; The stent body was soaked in solution A for 12 hours, and the temperature was controlled at 37°C. The inner surface coating of the formed stent was purple, and the coating was stable and did not peel off.
[0066] S200, forming a coating on the outer surface of the stent
[0067]The stent body was washed 8 times with deionized water to remove substances adhering to the outer wall of the stent body. Then add polytrimethylene carbonate (Mn=500000) and rosmarinic acid to 8mL of tetrahydrofuran, and stir and disperse at 50rpm to form solution B, so that the concen...
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Abstract
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