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Cetirizing hydrochloride cataplasm preparation

A technology of cetirizine hydrochloride and hydrochloric acid, which is applied in the field of medicine and achieves the effects of avoiding gastrointestinal irritation, reducing the number of administrations, and reducing blood drug concentration

Inactive Publication Date: 2005-04-20
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with other antihistamines, although the central nervous system activity of cetirizine hydrochloride is lower, it still has adverse reactions such as drowsiness, dizziness, and headache when taken orally

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1 Preparation of cetirizine hydrochloride cataplasm

[0012] Formula and ratio:

[0013] Gelatin 2g Carborite7S 0.4g

[0014] Sodium Carboxymethyl Cellulose 4g Ca(OH) 2 0.24g

[0015] Polyvinylpyrrolidone 6g Propylene glycol 20ml

[0016] D-Sorbitol 38g Kaolin 4g

[0017] 60ml distilled water 8g menthol

[0018] Glycerin 8ml Citric acid (10%) 0.5ml

[0019] Polyethylene Glycol-200 1g Cetirizine Hydrochloride 0.6g

[0020] The preparation method is:

[0021] 1. Prepare (I) phase solution: fully swell the gelatin with water according to the above ratio, dissolve it in a water bath at 60°C, mix the sodium carboxymethylcellulose, polyvinylpyrrolidone, and D-sorbitol evenly, and then add it to the gelatin solution. Stir to obtain (I) phase solution.

[0022] 2. Prepare (II) phase solution: dissolve menthol in propylene glycol, mix with Carborite7S, Ca(OH) 2 , kaolin, citric acid, and cetirizine hydrochloride are uniform...

Embodiment 2

[0024] Embodiment 2 Preparation of cetirizine hydrochloride cataplasm

[0025] Formula and ratio:

[0026] Gelatin 2g Carborite7S 0.2g

[0027] Sodium carboxymethylcellulose 4g Al(OH) 3 0.18g

[0028] Polyvinylpyrrolidone 4g Propylene Glycol 20ml

[0029] D-Sorbitol 32g Zinc Oxide 4g

[0030] Distilled water 60ml Camphor 6g

[0031] Glycerin 10ml Citric Acid (20%) 0.4ml

[0032] Isopropanol 1g Cetirizine Hydrochloride 0.6g

[0033] The preparation method is:

[0034] 1, prepare (I) phase solution (same as embodiment 1).

[0035] 2. Prepare (II) phase solution: dissolve camphor in propylene glycol, add Carborite7S, Al(OH) 3 , zinc oxide, citric acid, and cetirizine hydrochloride were uniformly mixed to obtain (II) phase solution.

[0036] 3. Mix (I) and (II) phase solutions, add 10ml glycerin, 1g isopropanol, stir well, spread on 150×240cm 2 On non-woven fabric, bake at 50°C for 30 minutes, cover with anti-sticking layer, cut into 5...

Embodiment 3

[0037] Example 3 Preparation of cetirizine hydrochloride cataplasm

[0038] Formula and ratio:

[0039] Gelatin 2g Carborite7S 0.6g

[0040] Sodium carboxymethylcellulose 3g AlCl 3 0.2g

[0041] Polyvinylpyrrolidone 6g Propylene glycol 20ml

[0042] D-Sorbitol 36g Kaolin 6g

[0043] Distilled water 80ml Azone 8g

[0044] Glycerin 10ml Citric acid (50%) 0.2ml

[0045] Oleic acid 0.5g Cetirizine hydrochloride 0.6g

[0046] The preparation method is:

[0047]1, prepare (I) phase solution (same as embodiment 1).

[0048] 2. Prepare (II) phase solution: mix azone, propylene glycol with Carborite7S, AlCl 3 , kaolin, citric acid, and cetirizine hydrochloride are uniformly mixed to obtain (II) phase solution.

[0049] 3. Mix (I) and (II) phase solutions, add 10ml glycerin, 0.5g oleic acid, stir well, spread on 150×240cm 2 On non-woven fabric, bake at 50°C for 30 minutes, cover with anti-sticking layer, cut into 5×8cm 2 The cataplasms are...

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Abstract

The invention relates to the technical field of medicine, and relates to a new dosage form of an antihistamine drug, Cetirizine Hydrochloride, namely a cataplasm. Cetirizine hydrochloride is a commonly used clinical drug, and the existing dosage forms are oral dosage forms, such as tablets, capsules, solutions and the like. Because cetirizine hydrochloride has a central inhibitory effect, the patient has adverse reactions such as drowsiness, dizziness, and headache after oral administration of the drug. The present invention uses cetirizine hydrochloride as the main medicine, adds different auxiliary materials to make cataplasm, and administers it through the transdermal route, which can not only avoid the stimulation of the gastrointestinal tract caused by oral administration, reduce the blood drug concentration of the whole body, and reduce the concentration of the central nervous system. Inhibitory effect, increase the drug concentration in the local affected area, and has the advantages of reducing the number of administrations, being convenient to use, improving the compliance of patients with medication, etc., providing a new dosage form for the clinical application of cetirizine.

Description

Technical field: [0001] The invention relates to the technical field of medicine, and relates to a new dosage form of the antihistamine cetirizine hydrochloride—a cataplasm. Background technique: [0002] Cetirizine hydrochloride is a second-generation antihistamine, which has a good therapeutic effect on allergic diseases of the skin, respiratory system and eyes, such as skin urticaria, allergic asthma, allergic rhinitis and allergic conjunctivitis. At present, the pharmaceutical dosage forms of this medicine include conventional dosage forms such as tablets, capsules, and solutions, and the route of administration is all oral. Compared with other antihistamines, although the central nervous system activity of cetirizine hydrochloride is lower, the drug still has adverse reactions such as drowsiness, dizziness, and headache when taken orally. Invention content: [0003] The invention provides a transdermal drug delivery preparation of cetirizine hydrochloride - cataplasm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/495A61K47/30A61P37/08
Inventor 胡晋红刘继勇童华朱全刚
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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