Quick acting and heart resurrecting oral disintegrating tablet and its preparation process
A heart-to-mouth and quick-acting technology, which is applied in the field of Suxiao Jiuxinkou disintegrating tablets and its preparation, can solve the problems of unstable content of Suxiao Jiuxin Pills, coma, inconvenient taking of severe patients, easy sublimation of borneol, etc., to improve bioavailability, It is convenient for first aid, prevention, and the effect of relieving chest tightness
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Embodiment 1
[0045] ·Selection and pretreatment of medicinal ingredients
[0046] Take 1 kg of Ligusticum chuanxiong and 10 liters of ethanol into the reaction tank, heat it back, extract for 10 hours, concentrate under reduced pressure, recover ethanol and volatile oil, and combine the volatile oil and concentrate. Take 10 g of the above volatile oil and add it to 50 g of ethanol solution containing 6% Eudragit E-100 to prepare the oil phase. Take another 1000ml of water, add 30g polyethylene glycol to disperse to form an aqueous phase; under the condition of stirring the aqueous phase, drop the organic phase into the aqueous phase at a uniform speed, crosslink and solidify to obtain the medicinal chuanxiong package carrier Medicine microcapsules; then 1000ml of excess water is used to extract the organic solvent, and then filtered and dried to obtain the easy-flowing encapsulated Ligusticum chuanxiong medicine microcapsules that can release medicinal ingredients. The solid Ligusticum chuanxi...
Embodiment 2
[0064] The selection and pretreatment of medicinal ingredients and the prescription of tablet preparation are the same as in Example 1.
[0065] The components of the tablet formula (by weight) are:
[0066] Medicinal Ingredients Ligusticum chuanxiong 4.40g
[0067] Medicated Borneol 5.60g
[0068] Microcrystalline cellulose 19.0g
[0069] Mannitol 14.4g
[0070] Sodium carboxymethyl starch 15.0g
[0071] Mint 0.25g
[0072] Stevioside 0.05g
[0073] Magnesium stearate 0.65g
[0074] Micronized silica gel 0.65g
[0075] 1000 pieces in total
[0076] ·Production: The specific preparation method is:
[0077] Crush the stevioside, peppermint, chuanxiong and borneol, respectively, and mix them evenly, and pass through an 80-mesh sieve. According to the prescribed amount, pass the sodium carboxymethyl starch, microcrystalline cellulose, mannitol, micronized silica gel, and magnesium stearate through an 80-mesh sieve respectively, mix well, and then mix with the m...
Embodiment 3
[0079] The selection and pretreatment of medicinal ingredients and the prescription of tablet preparation are the same as in Example 1.
[0080] The formula (by weight) components are:
[0081] Medicinal Ingredients Ligusticum chuanxiong 4.40g
[0082] Medicated Borneol 5.60g
[0083] Microcrystalline cellulose 21.00g
[0084] Mannitol 15.60g
[0085] Cross-linked polyvinylpyrrolidone 12.00g
[0086] Stevioside 0.05g
[0087] Mint 0.25g
[0088] Magnesium stearate 0.55g
[0089] Micro powder silica gel 0.55g
[0090] 1000 pieces in total
[0091] The specific preparation method is:
[0092] Crush the stevioside, the medicine-loaded Ligusticum chuanxiong and Borneol separately, pass through an 80-mesh sieve, weigh according to the prescription, and mix well. In addition, cross-linked polyvinylpyrrolidone, microcrystalline cellulose, mannitol, micro-powdered silica gel and magnesium stearate are respectively passed through an 80-mesh sieve, weighed according t...
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