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Medical supplementary material producing process

A manufacturing method and auxiliary material technology, applied in medical science, medical containers, medical packaging, etc., can solve problems such as local irritation, uneven film dressing, stickiness, etc., achieve excellent compatibility, significant curative effect, and use convenient effect

Inactive Publication Date: 2003-05-14
ZHUHAI CLEANSTAR CLEANING TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned prior art generally adopts water as a medium, uses acetic anhydride as a reactant, and carries out a heterogeneous reaction to make a dressing. The chemical modification site of the product will inevitably be unbalanced in the chemical reaction, and the film-type dressing produced is uneven and linear. The tensile strength of the product is not balanced, and the mechanical strength of the two dressings is significantly reduced
Some other products are gelatin composite products treated with copper amination, which are prone to swelling, stickiness, local irritation, and inflammatory reactions in tissue exudates

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Dissolve 10g of deacetylated chitin in 500ml of 1% acetic acid to form a 2% gel, make a film on a polyester board on a horizontal workbench, and dry it with hot air; immerse the film in 1500ml of chloroform, add 10 % Acetyl chloride / / 2% formyl chloride mixed solution 10ml, react at 0°C for 2 hours, take out the membrane, wash with 95% ethanol until neutral, air dry, then use 2000ml 0.5Mol, pH 7.0 phosphoric acid containing 15% glycerol The membrane was soaked in saline buffer for 2 hours and then air-dried. The resulting films can be used to prevent surgical adhesions or as artificial skin.

Embodiment 2

[0017] Dissolve 10g of deacetylated chitin in 500ml of 1% acetic acid to generate a 2% gel. On a horizontal workbench, make a film on a polyester board (thickness of the film is 0.2, length 400, width 400mm), and dry with hot air; Adhere to a layer of dissolvable carbon fiber net on the film again, then pour 1 / 2 amount of above-mentioned film-making gel on the attached net, and dry; the film attached to the net is immersed in 1500ml chloroform, add 10% acetyl chloride / / 2% formyl chloride mixed solution 10ml, react at 0°C for 2 hours, take out the membrane, wash with 95% ethanol until neutral, air-dry, then soak in 2000ml 0.5Mol, pH 7.0 phosphate buffer solution containing 15% glycerol The membrane was dried for 2 hours and then air-dried to obtain an artificial dura mater.

Embodiment 3

[0019] Dissolve 10g of deacetylated chitin in 200ml of 1% acetic acid to form a 5% gel, spin the silk under pressure, immerse the silk in 95% ethanol for dehydration, take it out and dry it, and then immerse the silk in 1500ml of chloroform medium , add 10ml of a mixed solution containing 10% acetyl chloride / / 2% formyl chloride, react at 4°C for 2 hours, take out the silk, wash it with acetone until it is neutral, and dry it in air; The silk was soaked in 1% glycerol phosphate buffer solution for 4 hours, stretched, and air-dried. The diameter of the silk was 0.15 mm, and the prepared silk was used as absorbable surgical suture.

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Abstract

The present invention relates to a producing process of medical supplementary material. The medical supplementary material is produced via reaction at certain conditions using chitosan as main raw material, chloroform as medium and acetyl chloride or formyl chloride as reactant. It is used in preparing film for preventing operational adhesion, artificial skin, artificial cerebral dura mater, absorbable catgut suture and medical rack. The said material has excellent compatibility with human tissue without foreign body inflammation, high drawing strength and high flexibility.

Description

technical field [0001] The present invention relates to a manufacturing method of medical auxiliary materials, more precisely, the present invention relates to a manufacturing method of medical auxiliary materials used for preventing surgical adhesion films and artificial skin, artificial dura mater, absorbable surgical sutures, and medical stents. Background technique [0002] The raw material used in the method of the invention is deacetylated chitin, which is a positively charged natural polysaccharide, and is a product obtained from shells of shrimps and crabs. During hundreds of millions of years of evolution, the exoskeleton of crustaceans has unique biological characteristics, which can inhibit the growth of fibroblasts, promote the growth of epithelial cells and inhibit the growth of bacteria. Polysaccharides prepared from this kind of carapace have good compatibility with human tissue, are non-toxic, non-irritating, and non-immunogenic to the human body, so they hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/60A61L33/08
Inventor 王浦林王晶晶王宁宁
Owner ZHUHAI CLEANSTAR CLEANING TECH
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