Tanshinone 11A used in preparing medicine for preventing and treating atherosclerosis

A technology of atherosclerosis and tanshinone, applied in the field of tanshinone 11A for the preparation of drugs for the prevention and treatment of atherosclerosis

Inactive Publication Date: 2003-07-02
广州美奇生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no report on the prevention and treatment of atherosclerosis with single-component tanshinone IIA

Method used

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  • Tanshinone 11A used in preparing medicine for preventing and treating atherosclerosis

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Dried Salvia miltiorrhiza 1kg, extracted with 95% ethanol for 3 times, each time for 24 hours, the extract was concentrated under reduced pressure to 500mL, then added 500mL of water, extracted four times with 1000mL chloroform, the extract was concentrated under reduced pressure, and the column layer Analysis and separation, the silica gel is 100-200 mesh, the eluent is petroleum ether / ethyl acetate mixed solution containing 1%-10% ethyl acetate, and gradient elution is carried out. About 0.85g of tanshinone IIA can be obtained. Embodiment 2: Tanshinone IIA reduces the experiment of hyperlipidemia animal model (rat) arterial vessel wall intima cholesterol deposition experiment

Embodiment 2

[0022] The experimental animals were 48 adult male rats (Sprague-Dawley) with a body weight of 150-200 g. Divided into normal control group, hyperlipidemia model control group, positive drug cholestyramine (500mg / kg) control group, tanshinone IIA high dose (300mg / kg), medium dose (100mg / kg), low dose (30mg / kg) G. Except for the normal control group, the other groups were fed with high cholesterol and lipid feed for 45 consecutive days.

[0023] High cholesterol and lipid feed formula: 3% cholesterol, 10% lard, 0.2% methylthiouracil and 88% basic feed.

[0024] Determination of cholesterol content in arterial wall: isopropanol extraction, high iron-acetic acid-sulfuric acid chromogenic method. The experimental results are shown in Table 1.

[0025] The reduction rate calculation method in Table 1 and the following tables: reduction rate=[1-(treatment group concentration-normal control group concentration) / hyperlipidemia model control group concentration-normal control group ...

Embodiment 3

[0028] The experimental animals were 48 adult male rats (Sprague-Dawley) with a body weight of 150-200 g. Divided into normal control group, hyperlipidemia model control group, positive drug cholestyramine (500mg / kg) control group, tanshinone IIA high dose (300mg / kg), medium dose (100mg / kg), low dose (30mg / kg) G. Except for the normal control group, the other groups were fed with high cholesterol and lipid feed for 45 consecutive days.

[0029] High cholesterol and lipid feed formula: 3% cholesterol, 10% lard, 0.2% methylthiouracil and 88% basic feed.

[0030] Determination method of serum cholesterol content: ferric-acetic acid-sulfuric acid chromogenic method. The experimental results are shown in Table 2.

[0031] The results of this experiment show that tanshinone IIA basically does not affect the metabolism of cholesterol. It shows that tanshinone IIA reduces the cholesterol deposition in the arterial intima through a new mechanism of action, that is, the competition ...

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Abstract

An application of tanshinone 11A to preparing the medicines for preventing and treating atherosclerosis and its related diseases is disclosed. The tanshinone 11A can reduce the deposit of cholesterol on the inner surface of artery.

Description

technical field [0001] The invention relates to a new medical application of tanshinone IIA, which is a single component in the salvia miltiorrhiza extract. It specifically relates to the use of tanshinone IIA for preparing drugs for preventing and treating atherosclerosis and diseases related to atherosclerosis. technical background [0002] Atherosclerosis is a systemic disease related to lipid metabolism disorders. Its lesion is characterized by the deposition of liposomes in the blood, especially the cholesterol in them, in the intima of the arterial wall to form atherosclerotic plaques, leading to arteriosclerosis . When atherosclerosis occurs in important organs such as the heart and brain, it will cause tissue ischemic changes and cause serious consequences, such as angina pectoris, myocardial infarction, cerebral infarction, renal tissue infarction, and arterial gangrene of the extremities. It is a serious threat to human health today....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/343A61P9/10
Inventor 古练权刘培庆李贵华
Owner 广州美奇生物科技有限公司
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