Nisoldipine double layer penetrated pump control releasing tablets

A technology of osmotic pump controlled release and nisoldipine, which is applied in the fields of cardiovascular system diseases, pharmaceutical formulations, drug combinations, etc., can solve the problems of frequent taking of ordinary tablets, long-lasting drug effects, large fluctuations in blood drug concentration, etc., to achieve The effect of long-lasting drug effect, small fluctuation of blood drug concentration, and less frequency of taking medicine

Inactive Publication Date: 2003-09-03
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] There are many nisoldipine drugs available in the market, but the common tablet of nisoldipine is taken frequently, which is inconvenient to take, the blood drug concentration fluctuates greatly, the drug effect is not long-lasting, the curative effect is not stable enough, and it has certain toxic and side effects

Method used

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  • Nisoldipine double layer penetrated pump control releasing tablets
  • Nisoldipine double layer penetrated pump control releasing tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The present embodiment 1 tablet that adopts the known method of pharmaceutical industry to make contains following composition by weight percentage:

[0020] Drug-containing layer:

[0021] Nisoldipine 5.5%

[0022] Polyoxyethylene (molecular weight: 100,000) 50.0%

[0023] Magnesium Stearate 0.2%

[0024] 10% PVP ethanol solution appropriate amount

[0025] Boost layer:

[0026] Polyoxyethylene (molecular weight 7 million) 27.8%

[0027] Hypromellose 1.4%

[0028] Sodium Chloride 11.1%

[0029] Povidone (K30) 2.8%

[0030] Magnesium Stearate 0.2%

[0031] 10% PVP ethanol solution appropriate amount

[0032] Composition of semi-permeable membrane coating solution:

[0033] Cellulose acetate 96.5%

[0034] Macrogol 4000 3.5%

[0035] Acetone: water 3.0% (w / v)

[0036] Composition of moisture-proof coating solution:

[0037] Hypromellose 42.9%

[0038] 1,2-Propanediol 2.0% (v / v)

[0039] Talc 28.6%

[0040] Titanium dioxide 28.6%

[0041] Ethanol: water ...

Embodiment 2

[0044] The present embodiment 1 tablet that adopts the known method of pharmaceutical industry to make contains following composition by weight percentage:

[0045] Drug-containing layer:

[0046] Nisoldipine 5.3%

[0047] Polyoxyethylene (molecular weight: 200,000) 42.1%

[0048] Sodium Chloride 10.5%

[0049] Magnesium Stearate 0.2%

[0050] 10% PVP ethanol solution appropriate amount

[0051] Boost layer:

[0052] Polyoxyethylene (molecular weight: 5 million) 26.1%

[0053] Sodium Chloride 9.5%

[0054] Povidone (K30) 2.8%

[0055] Magnesium Stearate 0.2%

[0056] 10% PVP ethanol solution appropriate amount

[0057] Composition of semi-permeable membrane coating solution:

[0058] Cellulose acetate 91.3%

[0059] Triethyl Citrate 6.3%

[0060] Macrogol 400 2.4%

[0061] Acetone: water 3.6% (w / v)

[0062] Nisoldipine is made into a double-layer osmotic pump controlled-release tablet by film coating technology, and the drug-containing layer is drilled by laser o...

Embodiment 3

[0064] The present embodiment 1 tablet that adopts the known method of pharmaceutical industry to make contains following composition by weight percentage:

[0065] Drug-containing layer:

[0066] Nisoldipine 5.5%

[0067] Carbopol 40.1%

[0068] Lactose 12.6%

[0069] Talc 0.2%

[0070] Boost layer:

[0071] Polyoxyethylene (molecular weight 6 million) 29.0%

[0072] Lactose 9.5%

[0073] Talc 0.2%

[0074] 10% PVP ethanol solution appropriate amount

[0075] Composition of semi-permeable membrane coating solution:

[0076] Cellulose acetate 80.7%

[0077] Ethylcellulose 9.2%

[0078] Methyl phthalate 10.1%

[0079] Acetone: water 2.1% (w / v)

[0080] Nisoldipine is made into a double-layer osmotic pump controlled-release tablet by film coating technology, and the drug-containing layer is drilled by laser or mechanically to achieve the purpose of controlled release.

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Abstract

A release controllable nisoldipine with dual-layer osmotic pump for treating cardiovascular diseases including hypertension, angine pectoris, left ventricular disfunction and congestive heart failure contains nisoldipine (5-20 wt.%), polyoxyethene and/or sodium chloride and/or hydroxypropyl methylcellulose as the release controlling agent of medicine layer, polyoxyethene and/or hydroxypropyl methylcellulose and/or ethylcellulose as the release controlling agent of boosting layer, and acetate cellulose and/or ethylcellulose and/or hydroxypropyl methylcellulose and/or polyethanediol as release-controlling membrane.

Description

Technical field: [0001] The invention relates to a nisoldipine drug for treating hypertension, angina pectoris, left ventricular insufficiency and congestive heart failure-nisoldipine double-layer osmotic pump controlled-release tablet. Background technique: [0002] There are many nisoldipine medicines available in the market, but the common nisoldipine tablet is taken frequently, which is inconvenient to take, the blood drug concentration fluctuates greatly, the drug effect is not durable, the curative effect is not stable enough, and there are certain toxic and side effects. Invention content: [0003] The object of the present invention is to provide a nisoldipine double-layer osmotic pump controlled-release tablet, which has the characteristics of convenient administration, long-lasting effect, stable curative effect and less toxic and side effects. [0004] The purpose of the present invention is achieved like this: [0005] Preparation of the present invention cont...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/4422A61P9/04A61P9/10A61P9/12
Inventor 潘卫三吴学明聂淑芳
Owner SHENYANG PHARMA UNIVERSITY
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