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Application of Chinese lizardtail herb and its extractive in preventing and treating prostatosis

A technology of Sanbaicao and its extracts, applied in the field of preventing and treating prostate diseases with Sanbaicao and its extracts

Inactive Publication Date: 2004-04-07
孙丽文
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no report that Sanbaicao has a preventive and therapeutic effect on prostate diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 3

[0013] Example 1 Therapeutic effect of three white grass extracts on non-bacterial prostatitis

[0014] Materials and Methods

[0015] 1. Animals and groups 40 healthy SD male rats, weighing 300-350g, were divided into normal control group (A), pathological model group (B), Sanbaicao group (C), positive group (D), each group 10.

[0016] 2. Modeling method After intraperitoneal injection of isopentobarbital sodium 100mg / kg anesthesia, the abdomen was incised in the midline, the abdominal cavity was opened, the bladder and seminal vesicles on both sides were raised, and the dorsal lobe of the prostate attached to the inner side of the seminal vesicles was exposed. The mice were injected with 25% Xiaozhiling injection 0.2ml / mice respectively, and the muscles and skin were sutured.

[0017] 3. Drugs and Treatment Methods Groups A and B were given normal saline; Group C was given 10ml / kg of Sanbai grass extract, containing 1 g of crude drug per ml; Group D was given 1.2g / kg of Q...

Embodiment 2 3

[0034] Example 2 Therapeutic effect of Sanbai grass extract on acute bacterial prostatitis

[0035] Materials and Methods

[0036] 1. Animals and groupings 50 healthy SD male rats, weighing 300-350g, were randomly divided into 5 groups: model control group, high, medium and low dose groups of S. chinensis, and positive group (cephalexin group).

[0037] 2. Experimental method The test drug was formulated into a suitable concentration of drug solution with deionized water for intragastric administration to animals, once a day for 7 consecutive days. The acute bacterial prostatitis model was established after administration on the 6th day: intraperitoneal injection of sodium pentobarbital anesthesia, injection of 0.1 ml of 400 million / ml E. One hour after the last administration, the prostatic fluid was extracted and the number of leukocytes and the density of lecithin bodies were recorded under a microscope.

[0038] result

[0039] Group Number of Animals Dose Leukocyte Num...

Embodiment 3 3

[0048] Example 3 Study on the anti-inflammatory effect of Sanbai grass extract

[0049] 1 Effects on the increase of peritoneal capillary permeability in mice induced by intraperitoneal injection of acetic acid

[0050] 1.1 Animals and Grouping 50 ICR mice, male, weighing 18-22 g, were randomly divided into 5 groups: normal control group, model control group, Sanbaicao large and small dose group, and positive group (aspirin).

[0051] 1.2 Experimental method The test drug was made into a suitable concentration of drug solution with deionized water for intragastric administration to animals, once a day for 7 consecutive days. After 1 hour of administration on the 7th day, inject 0.6% Evans blue normal saline solution 0.1ml / 10g body weight into the tail vein, and inject 0.7% acetic acid normal saline solution 0.1ml / 10g body weight intraperitoneally for 30 minutes in each group except the normal control group. They were killed by neck dislocation, and the peritoneal cavity was was...

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PUM

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Abstract

The present invention discloses the application of Chinese lizardtail herb and its derivative in preparing medicine, health article and compound preparation for preventing and treating prostatosis and its complication. Clinical application shows that Chinese lizardtail herb and its derivative has obvious curative effect on acute and chronic prostatitis and prostate hyperlosia, and Chinese lizardtail herb and its derivative has higher curative effect and less toxic side effect compared with Qianliekang tablet. Animal experiment shows that Chinese lizardtail herb and its derivative can eliminate prostate weight increment and swelling of rat caused by Xiaozhiling injection, remit inflammatory cell infiltration and damage, suppress fibrous tissue hyperplasia and treat abacterial prostatitis as well as treat prostate hyperplosia caused by Testosterone Propionas.

Description

Technical field [0001] The invention relates to the technical field of medicine and health care products, and relates to the use of Sanbai grass and its extract for preventing and treating prostate diseases. Background technique [0002] Prostate diseases include acute and chronic prostatitis, benign prostatic hyperplasia, prostate cancer, prostate diseases combined with other diseases of the urinary tract, such as urethritis, cystitis, bladder stones, diverticula, and hematuria caused by these lesions. At present, the treatment is difficult, and the general treatment is difficult to achieve the desired effect, and there is no effective drug in clinical practice. The research and development of drugs for the prevention, treatment and prognosis of prostate diseases is a research topic that countries all over the world attach great importance to. [0003] Rhizoma Saururi is a folk herbal medicine. The dried rhizoma or the whole grass can be used as medicine. The whole grass c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P13/08
Inventor 孙丽文朱锦桃徐文洪孙志坤
Owner 孙丽文
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