Preparation method of polylactic acid-polyethylene glycol block copolymer

Abstract

A process for preparing the polylactic acid-polyethanediol block copolymer is prepared through the copolymerizing reaction between polyethanediol and lactide at 130-160 deg.C under -0.08-0.01 MPa and existance of calcium hydride for 8-12 hr, adding acetone for dissolving, deposition in distilled water and then in absolute alcohol, and vacuum drying.

Description

technical field

[0001] The invention relates to a preparation method of a polyester polyether copolymer, more precisely, the invention relates to a preparation method of a polylactic acid-polyethylene glycol block copolymer, which belongs to the field of biomedical polymer materials. Background technique

[0002] In the past ten years, with the development of drug controlled release system and tissue engineering technology, biodegradable materials have been developed rapidly, and their application scope involves almost all non-permanent implant devices, including drug controlled release carriers, surgical sutures, etc. Sutures, internal fixation devices for fractures, artificial skin, surgical anti-adhesion membranes and tissue engineering, etc. The homopolymer of lactide, polylactic acid and its copolymer with glycolide, has good biocompatibility, non-toxic, biodegradable and can be metabolized by the body after fulfilling its purpose without leaving any Traces and other a...