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Externally used pharmaceutics for treating colpitis mycotica

A technology of external preparations for fungal vaginitis, applied in the field of medicine, can solve the problems of easy recurrence, inability to completely remove fungus, and long course of treatment, etc.

Inactive Publication Date: 2004-08-11
李跃亨
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These traditional external antibacterial agents cannot completely eliminate the fungus, and are prone to relapse after drug withdrawal. The course of treatment is long, and patients often cannot cooperate well with doctors.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Embodiment 1, butenafine hydrochloride vaginal effervescent tablet:

[0010] Prescription: butenafine hydrochloride 150g, tartaric acid 500g, boric acid 300g, sodium bicarbonate 500g, sodium carboxymethyl cellulose 40g, starch 300g, Tween-80 40g, appropriate amount of distilled water, lactose 300g, magnesium stearate 15g, ten Dialkyl sodium sulfate 10g.

[0011] Preparation method: Divide raw materials and auxiliary materials into 3 groups, pass through 80-mesh sieve respectively. Group 1: butenafine hydrochloride 150g, tartaric acid 500g, boric acid 300g; group 2: sodium bicarbonate 500g; group 3: sodium carboxymethylcellulose 40g, starch 300g. Take the sodium carboxymethyl cellulose in the third group, add 10 times the amount of water to swell naturally, add an appropriate amount of Tween-80 and stir evenly. Then the starch is made into 30ml by the pulping method, and an appropriate amount is fully mixed with the aforementioned carboxymethylcellulose sodium solution...

Embodiment 2

[0012] Embodiment 2, butenafine hydrochloride vaginal suppository:

[0013] Prescription: Butenafine Hydrochloride 30g, S-40 870g

[0014] Preparation method: Take S-40 and melt it on a water bath, grind butenafine hydrochloride finely, add it into the melted matrix and mix well, keep warm and pour it into a mold.

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PUM

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Abstract

An externally-applied medicine for treating the mycovaginitis features that it contains butenafine hydrochloride (2-15%). Its advantages are high curative effect, short course of treatment, no recurrence and low toxic by-effect.

Description

Technical field [0001] The invention relates to a single and compound external preparation specially used for treating fungal vaginitis, which belongs to the category of medicine. Background technique [0002] At present, oral and external preparations can be used in the clinical treatment of mycotic vaginitis. Oral drugs are mainly azole drugs, such as ketoconazole, fluconazole, and itraconazole, etc. Although their clinical therapeutic effects are good, they may cause drug resistance, severe gastrointestinal reactions, liver toxicity, and drug-drug interactions And other issues. Drugs for external use are relatively safe, there is no drug interaction, and it is relatively safe for pregnant women to use. The topical drugs currently used to treat fungal vaginitis are mostly imidazoles, such as clotrimazole suppository, miconazole nitrate suppository or vaginal cream, econazole sustained-release vaginal suppository, seconazole vaginal ointment, and sertaconazole slow-releas...

Claims

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Application Information

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IPC IPC(8): A61K9/02A61K9/06A61K9/08A61K9/10A61K9/12A61K9/20A61K31/137A61K31/41A61K31/60
Inventor 李跃亨姜涛马丽芳李莉
Owner 李跃亨
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