Bioactivity artificial joint material and preparation method thereof

A technology of artificial joints and bioactivity, applied in the field of biomedical materials, to achieve high bioactivity, good osteogenic effect, and good bioactivity

Inactive Publication Date: 2004-12-29
SOUTHEAST UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Technical problem: The purpose of the present invention is to address the above-mentioned shortcomings of artificial joint materials, and propose a bioactive artificial joint material with stable performance, which can significantly improve the ability of the artificial joint surface to induce osteogenesis at the initial stage of implantation, and its preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) First choose Ti6Al4V alloy to process the artificial joint;

[0029] (2) Artificial joint surface activation treatment: After the artificial joint is ultrasonically cleaned with acetone, 70% alcohol and distilled water successively, the concentration is 20% boiling H 2 o 2 Aqueous solution treatment, the treatment time is 45 minutes, take out and rinse, then soak in 4M NaOH aqueous solution at a temperature of 30-50°C for 24-36 hours, take out distilled water to rinse, and dry at 70°C.

[0030] (3) Biomimetic deposition treatment of calcium phosphate amorphous bottom layer: immerse the artificial joint treated with surface activation in biomimetic calcification solution A at a temperature of 20°C. Ion 4.5mM, Calcium ion 12.5mM, Chloride ion 610.0mM, Hydrogen phosphate ion 5.0mM, Bicarbonate ion 18.0mM. The biomimetic calcification solution A was stirred with a magnetic stirrer, taken out after 12-24 hours of biomimetic deposition treatment, ultrasonically cleaned ...

Embodiment 2

[0035] (1) First choose Ti6Al4V alloy to process the artificial joint;

[0036](2) Artificial joint surface activation treatment: After ultrasonically cleaning the artificial joint with acetone, 70% alcohol and distilled water successively, use 30% boiling H 2 o 2 Aqueous solution treatment, the treatment time is 90 minutes, take out and rinse, then soak in NaOH aqueous solution with a temperature of 60-70°C and a concentration of 8M for 24-36 hours, take out distilled water, rinse, and dry at 70°C.

[0037] (3) Biomimetic deposition treatment of calcium phosphate amorphous bottom layer: immerse the artificial joint treated with surface activation in biomimetic calcification solution A at a temperature of 30°C. Ion 4.5mM, Calcium ion 12.5mM, Chloride ion 610.0mM, Hydrogen phosphate ion 5.0mM, Bicarbonate ion 18.0mM. The biomimetic calcification solution A was stirred with a magnetic stirrer, taken out after 24-36 hours of biomimetic deposition treatment, ultrasonically clean...

Embodiment 3

[0042] (1) First select medical stainless steel to process the artificial joint;

[0043] (2) Artificial joint surface activation treatment: After the artificial joint is ultrasonically cleaned with acetone, 70% alcohol, and distilled water successively, the concentration is 50% boiling H 2 o 2 Aqueous solution treatment, the treatment time is 60 minutes, after taking out and rinsing, soak in NaOH aqueous solution with a temperature of 30-40°C and a concentration of 2M for 12-24 hours.

[0044] (3) Biomimetic deposition treatment of calcium phosphate amorphous bottom layer: immerse the artificial joint treated with surface activation in biomimetic calcification solution A at a temperature of 30°C. Ion 4.5mM, Calcium ion 12.5mM, Chloride ion 610.0mM, Hydrogen phosphate ion 5.0mM, Bicarbonate ion 18.0mM. The biomimetic calcification solution A was stirred with a magnetic stirrer, taken out after 30-36 hours of biomimetic deposition treatment, ultrasonically cleaned with distil...

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PUM

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Abstract

The present invention is one kind of artificial joint material with surface porous Ca-P bioactive ceramic coating layer and bone morphogenetic protein and its preparation process. The artificial joint material consists of metal substrate, one layer of double-layered porous Ca-P bioactive ceramic coating layer on the surface of the metal substrate, and bone morphogenetic protein covering the bioactive ceramic coating layer. The porous bioactive Ca-P ceramic coating layer comprises the non-crystal calcium phosphate base layer contacting with the metal substrate in 1-10 micron thickness and the crystalline bone-like apatite surface layer in 10-100 micron thickness. The preparation process includes machining artificial joint with titanium alloy, stainless steel or CO-Cr-Mo alloy; surface activating the artificial joint, two-step bionic deposition; and soaking the artificial joint inside mixed solution comprising bone morphogenetic protein and buffering phosphate solution.

Description

technical field [0001] The invention relates to a bioactive artificial joint material and a preparation method thereof, in particular to an artificial joint material with porous calcium-phosphorus bioactive ceramic coating and bone morphogenetic protein (BMP) prepared by a bionic method on the surface and a preparation method thereof , belongs to the technical field of biomedical materials. Background technique [0002] At present, the number of cases of artificial joint implanted into the human body can reach 1.2 million cases per year, and it is one of the implant materials with the largest demand in orthopedics at home and abroad. The commonly used artificial joints are metal materials. Because they are biologically inert materials, they cannot form a firm physiological bond with human bone tissue. After several years of implantation, they often loosen and sink, resulting in failure of artificial joint replacement. Second surgery is inevitable. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/30A61L27/04A61L27/32A61L27/34
Inventor 储成林林萍华浦跃朴薛小燕沈刚
Owner SOUTHEAST UNIV
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