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Metal micro needles array chip and preparation method, and usage

A technology of microneedle array and metal substrate, which is applied in other medical devices, drug devices, drug devices, etc., can solve the problems of restricting metal microneedles, and achieve the effect of simple process and good durability

Active Publication Date: 2005-01-12
SUZHOU NANOMED BIOMED CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] Metals such as titanium, stainless steel, nickel, etc. are biocompatible materials. However, due to the traditional processing methods that limit the development of metal microneedles, most of the current metal microneedles are produced by electroforming, and the most commonly used materials are metal microneedles. Nickel or Inconel

Method used

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  • Metal micro needles array chip and preparation method, and usage
  • Metal micro needles array chip and preparation method, and usage
  • Metal micro needles array chip and preparation method, and usage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1, multi-row metal microneedle array (out-of-plane)

[0043] See Figure 3.

[0044] a) A stainless steel sheet 1 with a thickness of 500 microns is washed with deionized water and dried after being cleaned with lotion. Then use chemical vapor deposition to deposit a layer of silicon dioxide 2 with a thickness of 1 micron on both surfaces of the metal as a protective layer for the metal, and spin-coat Shipley 1818 photoresist 3 with a thickness of 2 microns on the silicon dioxide on one side. , (shown in 3a);

[0045] b) Pre-bake (soft bake) at 90°C for 5 minutes, and form a 20×20 array of solid circles with a diameter of 80 microns and a pitch of 200 microns in a unit of 4 square millimeters. The substrate with photoresist is exposed for 4 seconds, then developed and dried at 120°C for about 30 minutes (see 3b); see the top view for the effect prepared by the steps;

[0046] c) Spin-coat Shipley 1818 photoresist 3 with a thickness of 2 microns on the silic...

Embodiment 2

[0052] Embodiment 2, single-row metal microneedle array (in-plane) manufacturing process

[0053] See Figure 4 .

[0054] a) After the 100 micron thick titanium sheet 1 is cleaned with lotion, it is rinsed with deionized water and dried; Silicon 2 is used as a protective layer of metal, and a 2-micron thick Shipley 1818 photoresist 3 is spin-coated on the silicon dioxide surface on one side of the substrate, (see 4a);

[0055] b) Pre-bake (soft bake) at 90°C for 5 minutes, cover the substrate with photoresist with a quartz glass mask with a microneedle pattern and expose it for 4 seconds, then develop and dry at 120°C for about 10 minutes; Spin-coat Shipley 1818 photoresist 3 with a thickness of 2 microns on the silicon dioxide surface on the other side of the substrate, pre-bake (soft bake) at 90°C for 5 minutes, and cover the photoresist with the quartz glass mask used in the previous step. Align and expose both sides of the glue for 4 seconds, then develop and dry at 12...

Embodiment 3

[0059] Embodiment 3, taking bovine serum albumin as the rat in vitro transdermal drug release of model drug

[0060] Dissolve bovine serum albumin in 0.25% carbomer (pH 6.5) solution to prepare a mixed solution containing 25mg / ml bovine serum albumin, get 40 microliters and add it to the surface of the microneedle prepared in Example 1 and dry it naturally at room temperature to form a mixture containing Polymer film microneedle preparation of bovine serum albumin. The microneedle has 400 needles in an area of ​​4 square millimeters, with a pitch of 200 micrometers between the needles.

[0061] Take a piece of hair-free rat skin, put the cuticle up at the mouth of the diffusion pool, place the solid microneedle prepared above on it, press the microneedle lightly with your hand to make micropores on the skin, but do not penetrate the skin, The stratum corneum of the skin faces the drug supply chamber, and the dermis faces the drug receiving chamber. Fill the receiving chamber ...

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Abstract

A metallic microneedle array chip for allowing the medicinal moleculae to penetrate the corneal layer of skin and come in human body without pain and irritation features that said metallic microneedles with the length just to penetrate the corneal layer are made up of metal material by microelectromechanical system (MEMS) and electrolytical polishing technique.

Description

technical field [0001] The invention relates to a metal microneedle array chip. [0002] The present invention also relates to a method for preparing the above-mentioned microneedle array chip. [0003] The present invention also relates to the use of the above-mentioned microneedle array chip. Background technique [0004] In general, drugs can be made into a variety of formulations, so there can be different routes and methods of administration. The route and method of administration affect the drug metabolism, thereby affecting the curative effect. [0005] Most drugs are currently administered orally in the form of tablets and capsules. However, due to the degradation of drugs in the gastrointestinal tract and the first-pass effect of the liver, many orally administered drugs are mostly or completely ineffective before reaching the site of action, such as many peptide and protein drugs are ineffective orally. In addition, the patient's medication adaptability is also...

Claims

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Application Information

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IPC IPC(8): A61M35/00A61M37/00
Inventor 徐百高云华
Owner SUZHOU NANOMED BIOMED CO LTD
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