Preparing method for growth factor slow-releasing system for tissue repair

A growth factor, tissue repair technology, applied in rayon manufacturing, textile and papermaking, fiber chemical characteristics, etc., can solve the problems of easy shedding, lack of fixation effect, complicated procedures, etc., to promote secretion and make up for drug release rate. The effect of reducing and simplifying the process

Inactive Publication Date: 2005-02-23
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The general method is to make a microsphere slow-release system loaded with growth factors first, and then coat it on the surface of the scaffold material. The process is complicated, and it does not achieve a good fixing effect, and it is easy to fall off.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) dissolving the mixture of PLA and BMP with a mass ratio of 4:1 in ether to form a solution with a concentration of 0.1g / mL, and then adding TEBA in an amount of 0.01g / mL to adjust the electrical properties of the solution;

[0023] (2) Electrospinning the prepared solution to obtain a nanofiber nonwoven fabric product with a fiber diameter of 800-1000 nm;

[0024] (3) Implant the prepared nanofiber non-woven fabric into the fracture site and fix it with bone screws to promote fracture healing.

Embodiment 2

[0026] (1) Dissolving the mixture of PLA and BMP with a mass ratio of 100:1 in ether to form a solution with a concentration of 0.01 g / mL;

[0027] (2) Electrospinning the prepared solution to obtain a nanofiber nonwoven fabric product with a fiber diameter of 400-600 nm;

[0028] (3) Implant the prepared nanofiber non-woven fabric into the fracture site and fix it with bone screws to promote fracture healing.

Embodiment 3

[0030] (1) Dissolve the mixture of PGA and BMP with a mass ratio of 1:1 in ether to make a solution with a concentration of 0.5g / mL, then add 0.1g / mL of TEBA and 0.001g / mL of lecithin to adjust the solution nature;

[0031] (2) Electrospinning the prepared solution to obtain a nanofiber nonwoven fabric product with a fiber diameter of 1200-1500 nm;

[0032] (3) Implant the prepared nanofiber non-woven fabric into the fracture site and fix it with bone screws to promote fracture healing.

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Abstract

The invention relates to electric filature to produce a kind of nano fiber growth gene slow-release system. This invention is compounded by biology decomposably polymer material and uses electric filature to produce a kind of nano fiber laxyly release system which contains growth gene. The method not only is operated easily and has a simple working procedure, but also can use the growth gene effectively in reducing the absent tissues. The laxly release system can emit growth gene steadily in body and avoids the lost of active of growth gene. More over, it can promote increasing of cells and tissue recovery. The production can not only be mad into the piece of velamen to transplant in the absent tissues for cure, but also be made into tissue engineering shelves to plant on cells and also be fostered out of body to increase cells for the tissue's renovation and then be transplanted in body to repair tissues.

Description

technical field [0001] The invention relates to a growth factor slow-release system for tissue repair, in particular to a method for preparing a growth factor-loaded nanofiber slow-release system by electrospinning technology. Background technique [0002] Growth factors are protein substances that have biological effects such as inducing and stimulating cell proliferation and maintaining cell survival. They play an important role in promoting cell proliferation, repair and regeneration of tissues or organs, and play an important role in tissue engineering. However, various growth factors are polypeptide protein substances, which are easy to lose their biological activity in the presence of water and at room temperature. If it is directly injected into the body, the growth factor will be rapidly diffused and degraded within a day, and cannot play a long-term role in promoting the repair of defective tissue. Therefore, how to maintain and prolong the biological activity of g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F1/10
Inventor 胡平施一平方壮熙
Owner TSINGHUA UNIV
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