Cefixime sodium pharmaceutical composition and its preparation and application

A pharmaceutical compound, cefixime technology, applied in the field of cefixime sodium pharmaceutical compounds, can solve the problems of poor water solubility of cefixime and the inability to prepare injections, etc., and achieve good water solubility, low cost and high curative effect
CN1594322AInactive Publication Date: 2005-03-16余安国
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Patent Information

Authority / Receiving Office
CN Ā· China
Patent Type
Applications(China)
Current Assignee / Owner
余安国
Publication Date
2005-03-16
Estimated Expiration
Not applicable Ā· inactive patent

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Abstract

The invention discloses a Ceftazidime pharmaceutical compound with a molecular formula of C16H13N5Na2O7S2, whose molecular weight is 497.5, the pharmaceutical compound is prepared by reacting 1 mol of Ceftzaidime with 2mol of sodium bicarbonate under normal temperature and ordinary pressure, charging ethanol for crystallization, recrystallization, and vacuum drying at below 60 deg. C.
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Description

Technical field:

[0001] The present invention relates to heterocyclic compounds containing nitrogen and sulfur, in particular to cefixime sodium pharmaceutical compound. The present invention also relates to the preparation method and application of the pharmaceutical compound. Background technique:

[0002] The antibiotic cefixime (Cefixime, C 16 h 15 N 5 o 7 S 2 ) is a third-generation oral cephalosporin antibiotic. Cefixime has a broad-spectrum antibacterial effect on Gram-positive and Gram-negative bacteria, especially influenzae (such as: Streptococcus pneumoniae, Streptococcus epidermidis), pneumococcus and Gram-negative bacteria among Gram-positive bacteria Haemophilus influenzae, Moraxella, Catarella, Proteus mirabilis, Neisseria gonorrhoeae, Branhamella catarrhalis, Escherichia coli, Klebsiella, Serratia, Proteus, Flowbacteria, etc. showed stronger bactericidal effect than other oral cephems. It has the characteristics of broad spectrum, high efficiency, enz...

Claims

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