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Cefixime sodium pharmaceutical composition and its preparation and application

A pharmaceutical compound, cefixime technology, applied in the field of cefixime sodium pharmaceutical compounds, can solve the problems of poor water solubility of cefixime and the inability to prepare injections, etc., and achieve good water solubility, low cost and high curative effect

Inactive Publication Date: 2005-03-16
余安国
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims to solve the problem that cefixime has poor water solubility and cannot be prepared into injections, and provides a cefixime sodium pharmaceutical compound, its preparation method and its application as an antibiotic

Method used

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  • Cefixime sodium pharmaceutical composition and its preparation and application
  • Cefixime sodium pharmaceutical composition and its preparation and application
  • Cefixime sodium pharmaceutical composition and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: the preparation of cefixime sodium

[0016] Under normal temperature and pressure, 507.5 grams of cefixime and 1680 grams of 10% aqueous sodium bicarbonate were added to the reaction flask, stirred and reacted for 2 hours, 10 grams of active carbon for needles was added, stirred for 20 minutes, filtered, and the filtrate was crystallized with ethanol. Suction filtration, vacuum drying at 50°C to obtain the primary product of cefixime sodium. Under aseptic conditions, recrystallize with ethanol aqueous solution, and vacuum-dry at 50°C to obtain 427 grams of cefixime sodium finished product.

[0017] Yield: 85.9%

[0018] Appearance: off-white crystalline powder

[0019] Content: 99.1%

[0020] PH: 7.2 (10% aqueous solution)

Embodiment 2

[0021] Embodiment 2: Preparation of Cefixime Sodium Powder for Injection

[0022] The cefixime sodium raw material is prepared and subpackaged according to the sterile powder injection process to obtain the cefixime sodium powder injection for injection.

Embodiment 3

[0023] Embodiment 3: Preparation of cefixime sodium freeze-dried powder for injection

[0024] Prescription Cefixime Sodium 500g

[0025] 5% sodium bicarbonate solution appropriate amount

[0026] Add water for injection to 1000ml

[0027] Preparation method Weigh 500 grams of cefixime sodium in a sterile operating room, put it in a sterile container, add sterile water for injection to about 500 ml, stir to dissolve, add 5% sodium bicarbonate solution to adjust the pH to 6.8-7.2 Within the range, add water for injection to a sufficient amount, then add 2% of the prepared activated carbon for needles, stir for 5-10 minutes, pre-filter, fine filter, sub-package, pre-freeze for about 2 hours, freeze-dry at low temperature for 24 hours, Add stopper and roll the cap to get it.

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Abstract

The invention discloses a Ceftazidime pharmaceutical compound with a molecular formula of C16H13N5Na2O7S2, whose molecular weight is 497.5, the pharmaceutical compound is prepared by reacting 1 mol of Ceftzaidime with 2mol of sodium bicarbonate under normal temperature and ordinary pressure, charging ethanol for crystallization, recrystallization, and vacuum drying at below 60 deg. C.

Description

Technical field: [0001] The present invention relates to heterocyclic compounds containing nitrogen and sulfur, in particular to cefixime sodium pharmaceutical compound. The present invention also relates to the preparation method and application of the pharmaceutical compound. Background technique: [0002] The antibiotic cefixime (Cefixime, C 16 h 15 N 5 o 7 S 2 ) is a third-generation oral cephalosporin antibiotic. Cefixime has a broad-spectrum antibacterial effect on Gram-positive and Gram-negative bacteria, especially influenzae (such as: Streptococcus pneumoniae, Streptococcus epidermidis), pneumococcus and Gram-negative bacteria among Gram-positive bacteria Haemophilus influenzae, Moraxella, Catarella, Proteus mirabilis, Neisseria gonorrhoeae, Branhamella catarrhalis, Escherichia coli, Klebsiella, Serratia, Proteus, Flowbacteria, etc. showed stronger bactericidal effect than other oral cephems. It has the characteristics of broad spectrum, high efficiency, enz...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/14A61K9/19A61K31/546A61P31/04C07D501/20
Inventor 余安国林国华唐朝云莫兆明李莎
Owner 余安国
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