Application of albi multisulfoxide and its salt in preparing medicine for preventing and treating respiratory tract virus infestation

A technology for virus infection and drug treatment, applied in the field of medicine, can solve problems that have not yet been reported

Inactive Publication Date: 2005-03-23
卢建英 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there have been no reports on the pharmacodynamics of albidol sulfoxide and its physiologically compatible acid addition salts.

Method used

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  • Application of albi multisulfoxide and its salt in preparing medicine for preventing and treating respiratory tract virus infestation
  • Application of albi multisulfoxide and its salt in preparing medicine for preventing and treating respiratory tract virus infestation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: In vitro anti-influenza virus experimental research of Albidol hydrochloride

[0020] 1. Materials and methods

[0021] 1. Virus: Influenza virus type A (H 1 N 1 and H 2 N 2 ) and type B were all quoted from the Institute of Virology, Chinese Academy of Preventive Medicine; influenza virus clinically isolated type A virus strains were provided by the Hebei Provincial Health and Epidemic Prevention Station; after the virus was inoculated with chicken embryos to increase the virus, the allantoic fluid was collected and stored at -70°C for later use.

[0022] 2. MDCK cell line: quoted from China Institute for the Control of Pharmaceutical and Biological Products.

[0023] 3. Drugs:

[0024] (1) Positive control drug: ribavirin (RBV), product of Hubei Keyi Pharmaceutical Factory, batch number (010913).

[0025] (2) Experimental drug: Albidol sulfoxide hydrochloride, provided by the Institute, batch number (020101).

[0026] 4. Drug preparation: dissolve in...

Embodiment 2

[0173] Embodiment 2: Preparation of Albidosulfoxide Hydrochloride Sodium Chloride Injection

[0174] (1) In the aseptic operation room, weigh 49.18g (0.036mol) of hydroxypropyl-β-cyclodextrin, then add 525mg of tartaric acid, add water to dissolve to 900ml, add 1g of activated carbon for infusion, stir and heat to 80°C, keep warm After 15 minutes, decarbonize by filtration.

[0175] (2) Weigh 10 g (0.018 mol) of albidol sulfoxide hydrochloride and add it into the hydroxypropyl-β-cyclodextrin solution.

[0176] (3) The liquid was mixed by magnetic stirring for about 20 minutes, and the solution gradually became clear, and the Albido sulfoxide hydrochloride-hydroxypropyl-β-cyclodextrin inclusion compound solution was obtained.

[0177] (4) Weigh 75g of sodium chloride for injection, add water to 1L, stir to dissolve, add 1g of activated carbon for infusion, heat to a slight boil for 15 minutes, and decarbonize.

[0178] (5) Pour the sodium chloride solution into the clathrate ...

Embodiment 3

[0180] Embodiment three: the preparation of albidol sulfoxide hydrochloride tablet

[0181] 1 recipe:

[0182] Albidosulfoxide Hydrochloride 100mg

[0183] Starch 83mg

[0184] Microcrystalline Cellulose 167mg

[0185] Cross-linked polyvinylpyrrolidone 15mg

[0186] 10% polyvinylpyrrolidone 80% ethanol appropriate amount

[0187] the solution

[0188] Sodium Lauryl Sulfate 2.5mg

[0189] Magnesium Stearate 2.5mg

[0190] Tablet weight about 400mg

[0191] 2Operation steps:

[0192] (1) Pass albidol sulfoxide hydrochloride through an 80-mesh sieve, weigh the prescription amount and mix it evenly with starch, microcrystalline cellulose and cross-linked polyvinylpyrrolidone.

[0193] (2) Use 15% polyvinylpyrrolidone and 85% ethanol solution to make soft materials, granulate with a 20-mesh sieve, dry at 50-55°C, and granulate with a 18-mesh sieve.

[0194] (3) Add sodium lauryl sulfate and magnesium stearate according to the weight of dry granules, and then compress into...

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Abstract

An application of Albiduoya sulfoxide and its biocompatible salts in preparing the medicines for preventing and treating the virus infection of respiratory tract, such as viral influenza, is disclosed.

Description

Technical field: [0001] The invention belongs to the field of medicine, and in particular relates to the application of albido sulfoxide or its physiologically compatible acid addition salt in the preparation of drugs for preventing and treating respiratory virus infection. Background technique: [0002] Influenza is an acute respiratory infectious disease caused by a virus that seriously endangers human health. The incidence rate accounts for the first place of all respiratory infectious diseases and often causes seasonal pandemics. Large-scale influenza epidemics have brought serious disasters to mankind in history. Now about 10% of people in the world still suffer from influenza every year, that is, more than 500 million people are infected with influenza virus. The United States alone loses millions of working days due to influenza every year, resulting in 20,000-40,000 deaths and 300,000 hospitalizations. Influenza has become one of the viral infectious diseases with th...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/216A61P11/00A61P31/12
Inventor 卢建英席英会廖兴珍张吉庆
Owner 卢建英
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