Internal fixer composite material with living things absorption and preparation

A composite material and fixing device technology, applied in the field of medical device materials and preparation, to achieve the effect of simple processing and good biocompatibility

Inactive Publication Date: 2005-05-11
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a composite material for orthopedic internal fixation devices and a manufacturing method of the composite material, so as to solve the defects of orthopedic internal fixation devices made of a single polylactic acid material

Method used

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  • Internal fixer composite material with living things absorption and preparation

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Embodiment 1

[0048] The poly-L-lactic acid with a viscosity average molecular weight of 160,000 and the polyglycolic acid with a viscosity average molecular weight of 300,000 are respectively pulverized into powders with a particle size of less than 200 microns; tricalcium phosphate and hydroxyapatite powders with a particle size of less than 50 microns are selected. Mixing poly-L-lactic acid, polyglycolic acid, tricalcium phosphate and hydroxyapatite in proportion, the weight percentage is 83%, 3%, 4%, 10%, and then adding pyrolytic carbon fiber with a volume percentage of 0.5% , mixed evenly, and then molded into rods and plates at 145 ° C and a pressure of 15 MPa, and processed into pins, screws, nails, and plates for orthopedic internal fixation devices by ordinary machining methods, and then filled with 5% polystyrene After soaking in poly-l-lysine aqueous solution for 12 hours, air-dry in airflow. The bending strength is 180MPa, and the shearing strength is 90MPa. After soaking in ph...

Embodiment 2

[0050] Grind poly-L-lactic acid with a viscosity-average molecular weight of 280,000 and polyglycolic acid with a viscosity average molecular weight of 280,000 and 120,000, respectively, into powders with a particle size of less than 200 microns; select tricalcium phosphate and hydroxyapatite powders with a particle size of less than 50 microns, and use silane coupling agent to treat the surface. Make acryloyloxy KH-570 silane coupling agent into 100ml of 1% water-alcohol mixture, add 50g of tricalcium phosphate and hydroxyapatite mixed powder, heat and stir for 2h, let stand for 4h, filter, Wash repeatedly with distilled water, dry, and pass through a 180-mesh sieve. Mix poly-L-lactic acid, polyglycolic acid, tricalcium phosphate and hydroxyapatite in proportion, and the weight percentage is 80%, 6%, 4%, 10%, mix well, and then extrude into rods at 205°C Materials and plates, which are processed into pins, screws, nails, plates orthopedic internal fixation devices by common ...

Embodiment 3

[0052] 350,000 poly-L-lactic acid and 200,000 polyglycolic acid with a viscosity-average molecular weight of 350,000 are pulverized into powders less than 200 microns in particle size; Methods Use silane coupling agent for surface treatment. Add pyrolytic carbon fiber to boiling K 2 MnO 4 and H 2 SO 4 After cleaning in the mixed solution, rinse repeatedly with distilled water, dry at 80°C for 2 hours, then treat the cleaned pyrolytic carbon fiber in a 1% water-alcohol mixture made of H-570 silane coupling agent, and rinse repeatedly with distilled water , then dry. Mix poly-L-lactic acid, polyglycolic acid, tricalcium phosphate and hydroxyapatite in proportion, the weight percentage is 75%, 5%, 6%, 14%, and then add pyrolytic carbon fiber with a volume percentage of 0.5% , mixed evenly, and then molded into rods and plates at 150 ° C under a pressure of 15 MPa, and processed into pins, screws, nails, and plates for orthopedic internal fixation devices by ordinary machinin...

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Abstract

A biologically absorbable composition used as internal fixer of bone fracture is prepared from polylactic acid, polyalcohol acid, tricalcium phosphate, apatite and carbon fibres through die pressing or extruding in the powder state or under existance of organic solvent. Its advantages are high biocompatibility and bone conductivity, and proper bending strength and shear strength.

Description

technical field [0001] The invention relates to a preparation and molding technology of a composite polymer material for orthopedic internal fixation devices, and belongs to the field of medical device materials and preparation. Background technique [0002] In order to treat various bone injuries, various orthopedic internal fixation devices, such as bone rods, bone screws, and bone plates, are used clinically. The materials for manufacturing orthopedic internal fixation devices are required to have mechanical properties and good biological characteristics that match the bone. At present, a large number of metal materials and absorbable polylactic acid polymer materials are used to manufacture fracture internal fixation devices. Orthopedic internal fixation devices made of metal, such as metal plates, metal screws, intramedullary nails, etc., are much stronger and tougher than human bones, and their mechanical properties cannot dynamically change with the bone healing proce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F5/05A61L15/64A61L31/04A61L31/14
Inventor 阮建明李亚军
Owner CENT SOUTH UNIV
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