Calcium gluconate oral disintegrating tablet and its preparation process
A technology for calcium gluconate and orally disintegrating tablets is applied in the field of calcium gluconate orally disintegrating tablet preparations, and can solve the problems of heavy economic burden on patients, great pain for patients, allergic reactions or adverse reactions caused by injections and the like.
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Embodiment 1
[0033] (1) Prescription
[0034] 1. Raw material - calcium gluconate 100.0g;
[0035] 2. Filling agent - mannitol 100.0g;
[0036] PROSOLV SMCC 35.0g;
[0037] 3. Disintegrant—croscarmellose sodium 10.0g;
[0038] 4. Glidant—micronized silica gel 2.5g;
[0039] 5. Lubricant - magnesium stearate 2.5g.
[0040] The total weight is 250.0g, and a total of 1000 pieces are made.
[0041] (2) Preparation method
[0042] 1) Take the calcium gluconate raw material and pulverize it, sieve it, and take the granules of 80 mesh to 40 mesh for subsequent use;
[0043] 2) the calcium gluconate and PROSOLV of step 1) Mix SMCC evenly and set aside;
[0044] 3) Mix mannitol (granular) and croscarmellose sodium evenly;
[0045] 4) Mix the micropowder silica gel and magnesium stearate evenly, then add the materials in step 2) and step 3), and mix evenly;
[0046] 5) Intermediate content detection, after determining the weight of the tablet, it is sent to a tablet press ...
Embodiment 2
[0048] (1) Prescription
[0049] 1. Raw material - calcium gluconate 500.0g;
[0050] 2. Adhesive - polyvinylpyrrolidone K-30 3.0g;
[0051] 3. Filling agent - mannitol 200.0g;
[0052] Microcrystalline cellulose 100.0g;
[0053] 4. Flavoring agent - aspartame 9.0g;
[0054] Orange essence 18.0g;
[0055] 5. Disintegrant—cross-linked polyvinylpyrrolidone 20.0g;
[0056]Croscarmellose 34.0g;
[0057] 6. Glidant—micronized silica gel 8.0g;
[0058] 7. Lubricant—magnesium stearate 8.0g.
[0059] The total weight is 900.0g, and a total of 1000 pieces are made.
[0060] (2) Preparation method
[0061] 1) Dissolve polyvinylpyrrolidone K-30 with 50% ethanol and dilute to a certain concentration for later use;
[0062] 2) Get calcium gluconate and microcrystalline cellulose to granulate with a high-speed mixing and stirring granulator, use the solution in step 1) as a binder, and dry it for subsequent use;
[0063] 3) Mix mannitol, micropowder silica...
Embodiment 3
[0067] (1) Prescription
[0068] 1. Raw material - calcium gluconate 150.0g;
[0069] 2. Coating material - Eudragit E100 15.0g;
[0070] 3. Filling agent - polysaccharide 175.0g;
[0071] 4. Flavoring agent - aspartame 4.0g;
[0072] Orange essence 8.0g;
[0073] 5. Disintegrant—cross-linked polyvinylpyrrolidone 26.0g;
[0074] Low-substituted hydroxypropyl methylcellulose 14.0g;
[0075] 6. Glidant—micronized silica gel 4.0g;
[0076] 7. Lubricant—magnesium stearate 4.0g.
[0077] The total weight is 400.0g, and a total of 1000 pieces are made.
[0078] (2) Preparation method
[0079] 1) Take Eudragit E100 is dissolved in more than 95% medicinal ethanol and diluted to a certain concentration for later use;
[0080] 2) Take calcium gluconate and place it in a fluidized bed to boil, spray the above solution at a certain speed for powder coating to obtain calcium gluconate powder-coated granules, and dry them for later use;
[0081] 3) Mi...
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