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Soft capsule of extractive from active ingredient of jingangteng, and preparation method

A technology of active ingredients and extracts, which is applied in the field of active ingredient extract soft capsules of King Kongteng, can solve problems such as inconvenient use, large dosage, and rough preparations, and achieve high stability, improved bioavailability, and bioavailability Good results

Inactive Publication Date: 2005-11-16
云南一尧科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are defects such as rough preparation, large dosage (syrup: 20ml / time, equivalent to 30g of crude drug), poor taste, and inconvenient use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Preparation of King Kongteng active ingredient extract: Get the King Kongteng meeting the drug standard, make it into a coarse powder, make it pass 10-20 mesh, and extract 30% ethanol with 6,5,5 times the concentration of 40-80% ethanol respectively Once, the concentration is preferably 55-70%. Combine the extracts, clarify with chitin or other clarifying agents, filter, concentrate at a temperature lower than 60°C, recover ethanol until the alcohol content is less than 20%, filter, and the filtrate Apply D101 macroporous resin, receive 45%-70% eluent, concentrate and recover ethanol until the alcohol content is less than 20%, filter once with a 0.4μm membrane, and filter again with a 0.2μm membrane, and concentrate the filtrate to contain The solid content is below 8%, spray drying is carried out by controlling the liquid intake, the inlet temperature is controlled at 78°C to 95°C, and the outlet temperature is at 70°C to 85°C to obtain a micronized extract with a parti...

Embodiment 2

[0020] Prescription (1000 capsules):

[0021] Vajra Rattan Extract Micronized Powder 75g

[0022] soybean oil 350g

[0023] Preparation method: Ultra-fine treatment is carried out by jet milling or ball milling for the extract of King Kong vine, so that the particle size is less than 200 μm, adding the ultra-fine King Kong vine extract into soybean oil, fully stirring, dissolving, filtering and degassing, Send it to the tank above the filling machine for use; at the same time, make gelatin solution for rubber skin from the gelatin in the thermal insulation gelatin tank above the soft capsule filling machine for use; at 10,000 grades, 22 ° C, RH%: 39% conditions Next, start the rotary molding machine to press the pellets, wash the soft capsules, dry them at 28±2°C for 22 hours, sub-package and package them to obtain the finished soft capsules each containing 75mg of King Kongteng extract.

Embodiment 3

[0025] Prescription (1000 capsules):

[0026] Vajra Rattan Extract Micronized Powder 105g

[0027] PEG-400 60g

[0028] 200g peanut oil

[0029] Perilla oil 25g

[0030] The method for embodiment 2 is made the soft capsule finished product that every grain contains 105mg of King Kong vine extract.

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PUM

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Abstract

A bock greenbrier rhizome's extract in the form of capsule is prepared from said extract and solvent proportionally.

Description

technical field [0001] The invention relates to an antibacterial and anti-inflammation soft capsule of active ingredient extract of King Kong vine for treating gynecological inflammation and a preparation method thereof. Background technique [0002] Vajra vine is a commonly used Chinese herbal medicine among the people. It has the functions of expelling wind and dampness, urinating, reducing swelling and toxins, and treating joint pain, edema, and boils. It has been reported in the literature that "King Kongteng" preparation has good curative effect on gynecological adnexitis and gynecological inflammatory mass. Pharmacological studies have shown that its water extract has good anti-inflammatory, analgesic and anti-tumor effects. King Kongteng is Smilar chiaa L., and studies have confirmed that the main components of King Kongteng in treating gynecological inflammation are steroidal glycosides. In addition, King Kongteng mainly contains saponins, alkaloids, organic acids, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
Inventor 任秀云
Owner 云南一尧科技开发有限公司