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Preparation technology of high purity erigeron breviscapus raw drug

A technology for preparing scutellarin and its preparation technology, which is applied in the field of preparation technology of raw materials, can solve the problems of improving the purity of scutellarin and eliminating side effects that have not been reported, and achieves easy industrial production, reduced toxicity, and improved safety Effect

Active Publication Date: 2006-01-11
KUNMING LONGJIN PHARMA
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Problems solved by technology

There is no report on the refining process of scutellarin in the relevant literature and patent materials, and there is no report on the improvement of the purity of scutellarin and the elimination of side effects

Method used

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  • Preparation technology of high purity erigeron breviscapus raw drug

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Embodiment

[0030] Weigh 1000 g of the raw material drug of Breviscapine in the market, add 5 times the weight of water, adjust the pH value to 7 with 25% sodium pyrophosphate test solution, make it completely dissolved, filter, add 8 times of acetone to the filtrate for precipitation, add while stirring, Make the precipitation complete, let stand for 10 hours, filter, add acetone to wash three times, then move the precipitate to another container, add 5 times the amount of 30% acetone, stir well, add 20% hydrochloric acid to adjust pH 1-2 and let stand 10 hours, suction filtration, washed with water until neutral, washed with ethanol once, and dried to obtain refined scutellarin. The content of B is 99.2888% by HPLC analysis, as shown in the accompanying drawing.

[0031] Detection method: chromatographic conditions and system suitability test (use octadecyl-bonded silica gel as filler: methanol-0.1% phosphoric acid solution (40:60) is mobile phase; detection wavelength is 335nm. The numb...

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Abstract

A process for preparing the high-purity raw material of breviscapine beta includes such steps as dissolving breviscapine in water, adding pH regulator to make pH=4-8, adding solvent depositing filter, washing the deposit with solvent, adding the deposit to the solvent solution, adding acid to make pH=1-2, filter, water wash and drying.

Description

technical field [0001] The invention relates to a preparation process of raw materials in the pharmaceutical industry, in particular to a preparation process of high-purity raw materials. Background technique [0002] Breviscapine is an active ingredient of flavonoids isolated from the whole herb of Erigeron breviscapus (Vant.) Hand-Mazz, mainly breviscapine B (also known as scutellarin B, scutellarin, hereinafter referred to as B) , the chemical name is 4'5, 6-trihydroxyflavone-7-O-glucuronide. The scutellarin crude drug currently purchased from the market is analyzed by HPLC, and the content of B is about 90%. This preparation has been widely used in the clinical treatment of cardiovascular and cerebrovascular diseases, with remarkable curative effect, but its injection has poor stability and short storage time. The appearance of the phenomenon is mainly caused by the failure to remove some of the impurities in the production process of the API. This problem has not been ...

Claims

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Application Information

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IPC IPC(8): C07H17/07
Inventor 张人伟程惠佳樊献俄
Owner KUNMING LONGJIN PHARMA
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