Skeleton pattern medicine film encapsulated alimentary tract stent

A skeleton type, digestive tract technology, applied in the field of digestive tract stents, can solve the problems of inability to prevent compressive restenosis due to excessive growth of tumors in the longitudinal direction, lack of local therapeutic effect, difficulty in reaching therapeutic concentration, etc., achieve good drug release effect, good The effects of drug loading capacity and appropriate drug release rate

Inactive Publication Date: 2006-04-26
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional metal stents and covered stents still have at least the following two shortcomings: ① they do not have real local therapeutic effects, and only play a role of mechanical support—short-term palliative effect of reducing symptoms, and they are powerless to prevent restenosis caused by tumor growth ; Although covered stents can prevent tumor ingrowth to a certain extent, they still cannot prevent tumor longitudinal overgrowth and oppressive restenosis
② After metal stent implantation, it is still necessary to cooperate with systemic drug treatment, but...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The invention comprises: a bracket, a backing layer and a multi-layer skeleton type medicine film layer, the backing layer is wrapped on the surface of the bracket, the backing layer is close to the bracket, and the multi-layer skeleton type medicine film layer is close to the backing layer.

[0024] The material of the backing layer is silicon rubber.

[0025] The multi-layer skeleton type drug film layer is one layer with a thickness of 3000um.

[0026] The drug-loaded polymer material used in the multi-layer skeleton drug film layer is polyurethane.

[0027] According to the requirements of the release rate, the multi-layer skeleton drug film layer contains a substance for regulating the release rate of the drug: porogen low molecular weight polyethylene glycol.

[0028] The anticancer drug contained in the multi-layer skeleton drug film layer is doxorubicin.

[0029] The present invention is used to treat stenosis caused by malignant esophageal tumors, not only ha...

Embodiment 2

[0031] The invention comprises: a bracket, a backing layer, a multi-layer skeleton type medicine film layer and a protective layer, the backing layer is wrapped on the surface of the bracket, the backing layer is close to the bracket, and the multilayer skeleton type medicine film layer is close to the backing layer Above, the protective layer is on the multi-layer framework type drug film layer.

[0032] The material of the backing layer is polytetrafluoroethylene.

[0033] The multi-layer skeleton drug film layer is composed of 10 submicrolayers, and the thickness of the submicrolayer is 20um. The drug loading of each submicrolayer is different, and the drug content of each layer increases sequentially from the outside to the inside.

[0034] The drug-loading macromolecular material used in the multi-layer skeleton drug film layer is ethylene / vinyl acetate copolymer.

[0035] According to the requirements of the release rate, the multi-layer skeleton drug film layer contai...

Embodiment 3

[0040] The invention comprises: a bracket, a backing layer and a multi-layer skeleton type medicine film layer, the backing layer is wrapped on the surface of the bracket, the backing layer is close to the bracket, and the multi-layer skeleton type medicine film layer is close to the backing layer.

[0041] The material of the backing layer is polystyrene.

[0042] The multi-layer skeleton drug film layer is composed of 100 submicrolayers, and the thickness of the submicrolayer is 10um. The drug loading of each submicrolayer is different, and the drug content of each layer increases sequentially from the inside to the outside.

[0043] The drug-loaded macromolecular material used in the multi-layer skeleton drug film layer is polyvinyl alcohol.

[0044] According to the requirements of the release rate, the multi-layer skeleton drug film layer contains a blocker diethyl phthalate.

[0045] The multi-layer skeleton drug film layer contains anticancer drug 5-fluorouracil.

[...

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Abstract

An alimentary canal supporting stand covered by the frame medicine membrane, belonging to the medical and medical appliance technique field. The first structure form of this invention comprises: supporting stand, back lining layer and multi-layer frame medicine membrane, the back lining layer is covered on the surface of the supporting stand, the back lining layer clings tightly to the supporting stand, and the multi-layer frame medicine membrane clings tightly to the back lining layer. The second structure form of this invention comprises: supporting stand and multi-layer frame medicine membrane, the multi-layer frame medicine membrane is covered on the supporting stand surface, and clings tightly to the supporting stand. The third structure form of this invention comprises: supporting stand, back lining layer, multi-layer frame medicine membrane and protective layer, the protective layer is installed on the multi-layer frame medicine membrane layer. The fourth structure form of this invention comprises: supporting stand, back lining layer, multi-layer frame medicine membrane and protective layer, the protective layer is installed on the multi-layer frame medicine membrane layer. The invention possesses the function of mechanical expansion, it can make the medicine act on the pathology tissue or the near place, thus provides medicine partly and slowly in the long run.

Description

technical field [0001] The invention relates to a component in the technical field of medicine and medical equipment, in particular to a skeleton-type drug-film-wrapped digestive tract stent. Background technique [0002] Gastrointestinal benign and malignant strictures are clinically common diseases. Among them, malignant stenosis of the digestive tract is a high-incidence disease in patients with digestive tract cancer. In addition to surgical resection, radiotherapy and chemotherapy, commonly used interventional methods mainly include balloon dilatation (mainly for benign strictures) and stent placement. For patients with advanced digestive tract cancer, stent implantation is a very important palliative treatment method, which can effectively improve the quality of life and prolong the survival time of patients with advanced digestive tract cancer. However, traditional metal stents and covered stents still have at least the following two shortcomings: ① they do not have...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/30A61M31/00
Inventor 郭圣荣郭庆海王中敏
Owner SHANGHAI JIAO TONG UNIV
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