Calcium nervonate and its preparing method and use

A technology of calcium nervate and nervus acid, applied in the field of chemistry, can solve the problems of poor calcium supplementation, great irritation of gastric mucosa, difficulty in human absorption, etc., and achieve the effect of improving effect, improving brain and promoting intelligence.

Inactive Publication Date: 2006-05-24
YUNNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, my country has attached great importance to calcium deficiency, but inorganic calcium supplements are very irritating to the gastric mucosa

Method used

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  • Calcium nervonate and its preparing method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1: Add 0.153g (2.73 mmol) calcium oxide (CaO) and 1.5mL distilled water in 50mL round-bottomed flask, make milk of lime under magnetic stirring, slowly add 2.0g (5.46mL mol) of nervonic acid and 20mL of absolute ethanol prepared nervonic acid ethanol solution, and reacted under magnetic stirring for 150min; after hot suction filtration, washed twice with ethanol and water respectively, and dried to obtain a white powdery solid, which was Dry in a constant temperature drying oven at 80°C for 2 to 3 hours to obtain the finished product of calcium neural acid, weighing 1.95g, with a yield of 92.8%. The elemental analysis, infrared spectrum analysis and calcium content determination of the product conform to the theoretical value.

Embodiment 2

[0014] Embodiment 2: Add 3.06g (54.64 mmol) calcium oxide (CaO) and 15mL distilled water in 500mL round bottom flask, make milk of lime under magnetic stirring, slowly add by 20g (54.64 mmol) under 65 ℃ of water bath conditions Nervous acid ethanol solution prepared by nervonic acid and 200mL 95% ethanol, and reacted under magnetic stirring for 180min; after hot suction filtration, washed twice with ethanol and water respectively, and dried to obtain a white powdery solid, at 80°C Dry in a constant temperature drying oven for 2 to 3 hours to obtain the finished product of calcium neural acid, weighing 20.6 g, with a yield of 98.1%. The elemental analysis, infrared spectrum analysis and calcium content determination of the product conform to the theoretical value.

Embodiment 3

[0015] Example 3: Add 1.0g (2.73 mmol) of nervonic acid in a 100mL round bottom flask, add 50mL of ethanol, fully stir to make it dissolve, slowly add 65mL of sodium hydroxide solution with concentration C=0.0426mol / L, until the pH is 7-8, heated in a water bath to 75°C, added 76 mg (1.37 mmol) of calcium oxide under magnetic stirring, and reacted for 150 minutes. During the reaction, a white precipitate was produced, and the reaction system changed from transparent to a white suspension. Suction filtration while it was hot, and obtained The solid was washed twice with ethanol and water respectively, drained and dried in a constant temperature drying oven at 80°C for 2 to 3 hours to obtain the finished product calcium neural acid with a yield of 78%.

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Abstract

The invention a relates to compound nervonic acid calcium salt and its preparing method and application. Its chemical name is z-15-cis-15-tetracosenic acid calcium salt, and its molecular formula is C48H90O4Ca, and its skeleton symbol is [CH3(CH2)7CH= CH(CH2)13COO]2Ca, its molecular weight is 771.3, and its melting point is 133-135 deg.C. The invention makes nervonic acid directly react with calcium oxide, or nervonic acid directly react with calcium oxide and calcium hydroxide, or nervonic acid directly react with calcium oxide, calcium hydroxide and calcium chloride on certain conditions to make it. It can regulate cranial n's system and functions of brain cells to a certain extent, able to strengthen the connective transfer between brain cells, and improve the action of calcium ions. And it can be singly made into health food or act as a nutrition strengthening agent; also act as health and medicinal raw material, made into tablets, capsules, powder and other health calcium

Description

technical field [0001] The invention relates to the field of chemistry, in particular to a new compound calcium neurate and its preparation method and application. Background technique [0002] Brain supplementation and calcium supplementation have always troubled people. How to find effective supplements and fortified products has become the focus of attention of researchers and manufacturers. At present, all kinds of brain nourishing health products that are popular in the market can be roughly divided into the following categories: supplementing brain nutrition, improving cerebral cortex excitement, promoting brain blood circulation, etc. From the analysis of its pharmacological components, part of it has a certain stimulating effect on the nervous system of the brain, and the other part has the function of calming and soothing, helping to enhance the sleep control or memory function of the brain. Nervous acid is a kind of neurotrophic factor, which is an essential compo...

Claims

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Application Information

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IPC IPC(8): C07C57/03A61K9/14A61K9/20A61K9/48C07C51/41
Inventor 林佩蓉董四花杨东福林军
Owner YUNNAN UNIV
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