Cyclic aliphatic acid ester carbonate, its polymer, synthesis method and uses thereof

A technology of cyclic aliphatic and aliphatic carbonates, which is applied in the field of biomedical polymer materials, can solve problems such as unsatisfactory biodegradation performance, difficulty in bonding drugs, and limited applications, and achieve low raw material prices and good hydrophilic/hydrophobic properties , high reactivity
CN1803884AInactive Publication Date: 2006-07-19CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Publication Date
2006-07-19
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The provided preparation methdo for cyclic aliphatic carbonate comprises: protecting two hydroxyl groups of the pentaerythritol to let another couple of hydroxyl react with ethyl chloroformate; further, ring-opening polymerizing or copolymerizing with aliphatic cyclic ester, removing the protection, and obtaining the product. This cyclic esters is fit to biodegradation without toxin, can connect the drug and active short peptide to improve the polymer bio- compatibility and bio-compatibility, and has wide application.
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Description

technical field

[0001] The invention relates to an aliphatic carbonate monomer with a side hydroxyl group, a polymer thereof, a synthesis method and an application thereof, and belongs to the field of biomedical polymer materials. Background technique

[0002] In recent decades, with the rapid development of polymer science and the rapid development of modern pharmacy, biology and engineering, the research on biomedical polymer materials has developed rapidly. Among them, biodegradable polymer materials have been widely used in the fields of surgical sutures, artificial skin, artificial blood vessels, bone fixation and repair, and controlled release of drugs because they do not require secondary surgery to remove after implantation. Biodegradable composite pole molecules mainly include aliphatic polyesters, polyamino acids, polyphosphates, polyanhydrides, polyorthoesters, polycarbonates, and the like. Aliphatic polyesters, such as polylactide (PLA), polyglycolide (PGA), pol...

Claims

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