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Controlled release type butyric acid, its preparation method and use

A slow-release butyric acid and butyrate radical technology, which is applied in the preparation of carboxylate salts, chemical instruments and methods, and the preparation of organic compounds, can solve the problems of irritating odor, strong corrosion and volatility, and difficult to use Convenience and other issues, achieve the effect of improving health level, maintaining normal barrier, and low cost

Inactive Publication Date: 2006-08-30
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Because butyric acid is a liquid under normal conditions, it is highly corrosive and volatile, and has a pungent odor, making it inconvenient to use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 1) Calcining commercially available hydrotalcite at a temperature of 450° C. to obtain a bimetallic oxide, then grinding to 500 mesh, adding water and stirring evenly to prepare a suspension slurry with a concentration of 10%;

[0036] 2) Slowly add n-butyric acid whose number of moles is 2 times that of the double metal oxide into the suspension slurry in step 1) under stirring, and react at room temperature for 15 hours;

[0037] 3) centrifugal dehydration of the suspension slurry in step 2);

[0038] 4) drying and pulverizing the filter cake obtained in step 3) to 300 mesh to obtain controlled-release butyric acid. Butyrate accounts for 100% of the total anions in the hydrotalcite interlayer.

[0039] According to the requirements of the feeding experiment, 72 "Du Changda" three-way hybrid piglets with a weight of about 8.3 kg were divided into 3 groups, with 3 replicates in each group and 8 pigs in each replicate. Controlled-release butyric acid group: basal diet ...

Embodiment 2

[0041] 1) Grinding commercially available hydrotalcite to 400 mesh, adding water and stirring evenly to make a suspension slurry with a concentration of 4%;

[0042] 2) Slowly add sodium n-butyrate, whose molar number is 2 times that of hydrotalcite, into the suspension slurry in step 1) under stirring, and react at room temperature for 10 hours;

[0043] 3) the suspension slurry in step 2) is filtered and dehydrated;

[0044] 4) drying and pulverizing the filter cake obtained in step 3) to 500 mesh to obtain controlled-release butyric acid. Butyrate accounts for 85% of the total anions in the hydrotalcite interlayer.

[0045] Select 240 male and female mixed chicks from healthy Avian commercial products, and randomly divide them into 2 groups (3 replicates in each group, 40 pigeons in each replicate), and feed them with 0 and 0.75g / kg controlled-release butyric acid respectively. of feed. Under the condition of ad libitum feeding, drinking water and 24-hour light, a feedin...

Embodiment 3

[0047] Preparation: hydrotalcite was prepared according to the method of "hydrothermal synthesis of magnesium-aluminum hydrotalcite" (Xie Hui, Jiao Qingze, Duan Xue. Applied Chemistry, 2001, 18: 70-72).

[0048] 1) calcining the hydrotalcite obtained in the preparatory step at a temperature of 550° C. to obtain a bimetallic oxide, then grinding to 600 mesh, adding water and stirring evenly to prepare a suspension slurry with a concentration of 5%;

[0049] 2) Potassium n-butyrate, whose molar number is 1.5 times that of the double metal oxide, is slowly added to the suspension slurry in step 1) under stirring, and reacted at room temperature for 15 hours;

[0050] 3) centrifugal dehydration of the suspension slurry in step 2);

[0051] 4) drying and pulverizing the filter cake obtained in step 3) to 400 mesh to obtain controlled-release butyric acid. Butyrate accounts for 90% of the total anions in the hydrotalcite interlayer.

[0052] 48 Du Changjia growing pigs weighing ab...

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Abstract

The present invention discloses a controlled slowly-released butyric acid, its preparation method and application. It is a controlled slowly-released type butyric acid using hydrotalcite as carrier, the butyric acid radical content is 80-100% of the hydrotalcite interlamellar anion total amount. Its preparation method is characterized by that said method utilizes the intercalation assembly behaviour possessed by hydrotalcite to make the butyric acid radical be inserted into the between of layers of hydrotalcite or calcines the hydrotalcite to 450-550 deg.C to obtain bimetal oxide and utilizes the property of bimetal oxide which can utilize lamellar structure reconstruction to adsorb anion to carry butyric acid. Because the hydrotalcite has the characteristics of good biological compatibility, gastrointestinal mucosa affinity and interlamellar exchangeability, high surface activity and large specific surface area, so that it has control slow release action for loaded butyric acid. It can be used as animal feed additive, and can be used for raising animal health level.

Description

technical field [0001] The invention relates to a controlled and sustained-release butyric acid, its preparation method and application. Background technique [0002] The biological functions of butyric acid are as follows: [0003] (1) Maintain beneficial microbial flora in the gastrointestinal tract [0004] A very important feature of a normal gastrointestinal tract, especially in young animals, is a well-balanced balance of bacteria within it. Butyric acid has a positive effect on the selection of microflora, which can promote the growth of beneficial bacteria and inhibit the growth of harmful bacteria (such as E. coli and Salmonella). [0005] (2) Promote the proliferation and maturation of gastrointestinal tract cells, maintain the normal morphology of intestinal mucosal epithelial cells, and maintain the normal barrier function of intestinal mucosa [0006] The digestive tract of young animals is not perfect, and the secretion of digestive enzymes such as amylase, ...

Claims

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Application Information

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IPC IPC(8): C07C53/124C07C51/00A23K1/16A23K20/105
Inventor 胡彩虹夏枚生张红梅
Owner ZHEJIANG UNIV
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