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Minipill for treating gastric disease and preparation method thereof

A micropill and stomach disease technology, which is applied in the field of medicine, can solve the problems of not being able to stop stomach pain in a short period of time, not being able to disperse quickly, and affecting the treatment effect, so as to achieve significant curative effect, quick onset and improved curative effect

Inactive Publication Date: 2006-10-04
修涞贵
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The content of the capsule is a powdery compound drug, which contains antacid drug aluminum hydroxide, which neutralizes or absorbs gastric acid after oral administration, thus weakening or eliminating the stimulation and corrosion of gastric acid on the ulcer surface, and forming a film in the stomach Prevent the erosion of gastric acid; however, when the hard capsule shell disintegrates, due to the insoluble characteristics of aluminum hydroxide, the capsule content and gastric juice form an interface, which becomes a gel state and cannot be dispersed quickly, and cannot be stopped in a short time Stomach pain, stomach acid, and bloating, which affect the treatment effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take vitamin U 50g, aluminum hydroxide 140, belladonna extract 10g,

[0026] Compressible starch 300g, carboxymethyl starch sodium 20g, povidone K-30 10g spare;

[0027] Preparation:

[0028] 1. Take aluminum hydroxide, vitamin U, compressible starch, and sodium carboxymethyl starch through an 80-mesh sieve, and mix them uniformly;

[0029] 2. Take the belladonna extract and add it to the mixed powder in step 1, absorb it and mix it routinely;

[0030] 3. For the preparation of adhesive, take povidone K-30 and add 90% (v / v) ethanol to dissolve it, and make a solution with a concentration of 5% (g / g);

[0031] 4. Take the mixed powder in step 2 and add 200g of the binder prepared in step 3 to make a soft material, and granulate it with a 24-mesh screen;

[0032] 5. Pour the wet particles into the shot blasting machine and throw them round. Spray 60ml of 95% (v / v) ethanol during the shot blasting process to adjust the humidity of the particles and facilitate the format...

Embodiment 2

[0036] Take vitamin U 50g, aluminum hydroxide 140g, belladonna extract 10g, microcrystalline cellulose 300g,

[0037] Crospovidone 20g, povidone K-30 10g for later use;

[0038] Preparation Process:

[0039] 1. Take aluminum hydroxide, vitamin U, microcrystalline cellulose, and crospovidone to pass through an 80-mesh sieve, and mix them uniformly;

[0040] 2 to 3, the same as steps 2 to 3 of embodiment 1;

[0041] 4. Take the mixed powder in step 2 and add 200g of binder to make a soft material, and granulate with a 24-mesh screen;

[0042] Steps 5 to 7 are the same as Steps 5 to 7 of Embodiment 1.

Embodiment 3

[0044] Take vitamin U 50g, aluminum hydroxide 140g, belladonna extract 10g, microcrystalline cellulose 200g, compressible starch 150g, crospovidone 30g, povidone K-30 25g for later use;

[0045] Preparation:

[0046] 1. Take aluminum hydroxide, vitamin U, microcrystalline cellulose, compressible starch, and crospovidone to pass through an 80-mesh sieve, and mix them uniformly;

[0047] 2. Same as step 2 of embodiment 1;

[0048] 3. For the preparation of adhesive, take povidone K-30 and add 90% (v / v) ethanol to dissolve it, and make a solution with a concentration of 10% (g / g);

[0049] 4. Take the 2-step mixed powder and add 250g of binder to make a soft material, and granulate it with a 24-mesh sieve.

[0050] Steps 5 to 7 are the same as Steps 5 to 7 of Embodiment 1.

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PUM

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Abstract

The invention provides pellets for treating gastropathy and the preparing process, wherein the pullets comprise vitamin U, aluminum hydroxide, belladonna extract, excipient, crumbling agent, Kollidon, the preparing process consists of sieving, mixing homogeneously, making soft material, granulating, shot-blasting, aeration-drying, and loading into capsules.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a medicine for treating stomach diseases, and the international patent classification numbers are A61K35 / 78 and A61P1 / 04. Background technique [0002] At present, hard capsule drugs with vitamin U (iodomethylmethionine), aluminum hydroxide, and belladonna extract as active ingredients have relatively good curative effects in the treatment of stomach pain, gastric acid, and bloating, and are very popular among patients with stomach problems. . The content of the capsule is a powdery compound drug, which contains antacid drug aluminum hydroxide, which neutralizes or absorbs gastric acid after oral administration, thus weakening or eliminating the stimulation and corrosion of gastric acid on the ulcer surface, and forming a film in the stomach Prevent the erosion of gastric acid; however, when the hard capsule shell disintegrates, due to the insoluble characteristics of aluminum...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61K9/16A61P1/04A61K33/06A61K31/198
Inventor 张显涛高陆白冰王鑫
Owner 修涞贵
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