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Aluminium ion investigating method using glycosyl naphthol

An aluminum ion and determination method technology, applied in the field of ion detection, can solve the problems of no selectivity, interference, and influence on the measurement accuracy of the color reaction, and achieve the effects of high selectivity, high sensitivity, and convenient use.

Inactive Publication Date: 2006-11-29
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

M.J.Ruedas Rama, A.Ruiz Medina, A.Molina Díaz, Talanta 62 (2004) 879-886) but this method requires the use of expensive fixed equipment, the color reaction is not selective, and is susceptible to interference from other coexisting ions. Measurement accuracy

Method used

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  • Aluminium ion investigating method using glycosyl naphthol
  • Aluminium ion investigating method using glycosyl naphthol
  • Aluminium ion investigating method using glycosyl naphthol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 (synthesis of fluorescent compound)

[0023] Dissolve 1.722g (10mmol) of 2-hydroxyl-1-naphthalene aldehyde in 100ml of anhydrous methanol, add 2.152g (10mmol) of D-glucosamine hydrochloride and 2ml of triethylamine, heat to reflux for 60 minutes, and cool to room temperature , filtered, and the light yellow precipitate was collected, washed with water, methanol, and anhydrous ether several times. Vacuum dry. Yield: 60%. Elemental Analysis: Calculated Value C 17 h 19 NO 6 C 61.26, H 5.75, N 4.20% Tested: C 61.36 H 5.82 N 4.17%. After single crystal cultivation, the single crystal structure was measured (see attached figure 2 ).

Embodiment 2

[0024] Embodiment 2 (absorption spectrum after reacting with aluminum ion)

[0025] Get the compound of Example 1, configure it into an aqueous solution, and test the UV-visible spectrum after 20 times of aluminum ions. The concentration of the compound of Example 1 is 1×10 -5 mol·1 -1 . See image 3 .

Embodiment 3

[0026] Embodiment 3 (fluorescence spectrum and concentration intensity working curve)

[0027] Take by weighing the compound 0.0017 gram of embodiment 1, be dissolved in water, be mixed with 1 * 10 with 500ML volumetric flask -5 M standard stock solution (L). Weigh 0.0150 g of aluminum nitrate nonahydrate, dissolve in water, and prepare 4.0×10 -3Standard stock solution of M (F). Measure 2 milliliters of stock solution L, add the stock solution F of calculated amount, be mixed with standard test solution, scan and record fluorescence spectrum (see attached Figure 4 ), excited at 370nm, and tested its fluorescence intensity at 431nm (see attached Figure 5 ). The binding constant of the compound of Example 1 to aluminum ions was calculated by nonlinear least square method as log K=5.67±0.08.

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Abstract

The invention discloses a method for making aluminum ion fluorescent detection based on selective aluminum cation recognizing and binding of 2-desoxy-2- [(E)-[2-hydroxyl-1-2-hydroxyl-1-naphthoicmethylene]amino] -D-glucose compound obtained by condensation of naphthoic aldehyde and D-glucosamine, where the compound can make high-selectivity aluminum ion fluorescent detection, and can obviously detect aluminum ion concentration down to 0.013ppm, without interferences of other ions such as Li(I),Na(I),K(I),Ag(I),Mg(II),Ca(II),Cu(II),Ba(II),Pb(II),Mn(II),Co(II),Ni(II),Cd(II),Zn(II) and Hg(II). And it provides a method for detecting aluminum ions in water sample in high selectivity and high sensitivity.

Description

technical field [0001] The invention belongs to the technical field of recognition combination and ion detection for optical detection of aluminum cations, and specifically relates to an aluminum ion fluorescence detection method using a glycosyl naphthol compound as a color development for recognition. Background technique [0002] Over twenty years ago it was discovered that excess Al 3+ Ions can cause damage to the human body, especially for patients with bone diseases and uremia, the accumulation of aluminum ions can result in nerve damage. (Alfrey AC Aluminum: Adv Clin Chem 1983, 23: 69-91. Weberg R, Berstad A: Gastrointestinal absorption of aluminum from single doses of aluminum containing antacids in man. Eur J Clin Invest 1986, 16: 428-432.) American Food The Drug Administration has required that the content of aluminum ions in injection medicines should not exceed 25 μg / L. For patients who are susceptible to the influence of aluminum ions, pharmacists should remind...

Claims

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Application Information

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IPC IPC(8): G01N21/64G01N21/78G01N33/84C07H5/06
Inventor 段春迎白志平区升举廖海平林志华赵永刚张丙广
Owner NANJING UNIV
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