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Medicinal composition for treating acute and chronic conjunctivitis for eye and its preparing method

A technology for chronic conjunctivitis and composition, which is applied to the ophthalmic pharmaceutical composition prepared from the Chinese medicinal material wild chrysanthemum as raw material and the field of preparation thereof, can solve the problems of complex raw material components, no product formed, different quality requirements, etc. Wide range of drug sources, small side effects, and the effect of meeting quality requirements

Inactive Publication Date: 2007-01-24
成都三明药物研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Shen Lizhen, the clinical application of chrysanthemum in ophthalmology, Chinese Journal of Ophthalmology of Traditional Chinese Medicine, 2001, 11 (2), reported that chrysanthemum (white chrysanthemum, yellow chrysanthemum, wild chrysanthemum) can treat external eye heat diseases, such as acute and chronic conjunctivitis, wherein wild chrysanthemum is mostly targeted at Various chemical injuries, thermal burns and other heat-toxin-congested diseases, but due to the complex composition of raw materials, different extraction methods of medicinal materials may produce different medicinal effects
Although Yechrysanthemum Injection has also been reported to be used for ophthalmic diseases, the quality requirements of injections and eye drops are different, and the selection of additives is different. Due to the particularity of the ophthalmic environment, injections cannot be directly used in eye drops. There is no report on the preparation of ophthalmic preparations from wild chrysanthemum flowers, and no related products

Method used

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  • Medicinal composition for treating acute and chronic conjunctivitis for eye and its preparing method

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Example 1 Preparation of the drug eye drops of the present invention

[0029] 1. Raw materials: 1000g of wild chrysanthemum, 5ml of Tween 80, 8g of boric acid, 0.05g of benzalkonium chloride, and 1000ml of 20% sodium hydroxide.

[0030] Second, the preparation process

[0031] 1. Take 1000g of wild chrysanthemum, add 10 volumes of water and soak for 1 hour, steam distillation, collect the first distillate 1000ml, and then re-distill, collect 500ml of the heavy distillate for use

[0032] 2. Collect the decoction liquid in the medicine residue, filter, add 8 volumes of water to the medicine residue, decoct twice, 1 hour each time, filter, combine the filtrate, and concentrate to a relative density of 1.20~1.24 (40~70℃) ), add ethanol to make the alcohol content reach 65%, refrigerate, and let stand for 16 hours;

[0033] 3. Filter, recover ethanol under reduced pressure and concentrate it to a clear paste with a relative density of 1.18~2.22 (40~70℃), let it cool, add ethanol...

experiment example 2

[0036] Experimental example 2 Preparation of the drug eye drops of the present invention

[0037] a. Take 1000g of the whole herb Chrysanthemum indicum L., soak in water, distill and redistill by steam distillation, collect the redistilled liquid, and reserve; collect the extract from the medicinal residue, filter, and reserve the remaining medicine Slag for the next step;

[0038] b. Decoct the dregs of step a with water, filter, combine with the filtrate in step a, concentrate, add ethanol to make the alcohol content 50%, let stand, filter, recover the ethanol, then concentrate, add ethanol to make the alcohol content 50%, let it stand, repeat alcohol precipitation 3 times in this way, filter, and use the filtrate for later use;

[0039] c. Take the filtrate from step b, recover the ethanol under reduced pressure and concentrate it until there is no alcohol, add water for injection to 500ml, refrigerate for 12 hours, filter, and add 0.3% activated carbon to the filtrate for adso...

experiment example 3

[0041] Experimental example 3 Preparation of the drug eye drops of the present invention

[0042] a. Take 1000g of wild chrysanthemum medicinal material, soak in water, distill and re-distill with steam distillation, collect the re-distilled liquid, and reserve; collect the extract in the medicinal residue, filter, and reserve. The remaining medicinal residue is used for the next step;

[0043] b. Decoct the dregs of step a with water, filter, combine with the filtrate in step a, concentrate, add ethanol to make the alcohol content 90%, let stand, filter, recover the ethanol, then concentrate, add ethanol to make the alcohol content 90%, let stand, repeat alcohol precipitation twice in this way, filter, and reserve the filtrate;

[0044] c. Take the filtrate from step b, recover the ethanol under reduced pressure and concentrate until there is no alcohol, add water for injection to 500ml, refrigerate for 12 hours, filter, add 0.3% activated carbon to the filtrate, filter; mix the ...

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Abstract

The present invention provides a kind of medicine composition for treating acute and chronic conjunctivitis of eye, and is especially one kind of ophthalmic preparation with the extract of wild chrysanthemum flower as one Chinese medicinal material as active component and pharmaceutically acceptable supplementary material. The present invention also provides the preparation process of the ophthalmic medicine composition. The ophthalmic medicine composition of the present invention has wide medicine material source, determined curative effect, controllable quality, less side effect and less drug resistance.

Description

Technical field [0001] The invention relates to an ophthalmic pharmaceutical composition for the treatment of acute and chronic conjunctivitis and a preparation method thereof, in particular, an ophthalmic pharmaceutical composition prepared from a Chinese medicinal material wild chrysanthemum as a raw material and a preparation method thereof, and belongs to the field of medicine . Background technique [0002] Conjunctivitis is a frequently-occurring disease in ophthalmology and is the first of all conjunctivitis. The etiology is nothing more than two categories: microbial and non-microbial. As far as microbiology is concerned, bacteria, viruses, parasites, etc. can cause conjunctival inflammation, and the sources are very wide. They can come directly from the outside world or from themselves, and their own infections may be transferred to the conjunctiva through the bloodstream or lymph fluid ( Tuberculosis, etc.); or directly spread from adjacent tissues, such as the eyeball ...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61K31/7048A61K9/08A61K9/00A61K47/34A61P27/02A61K47/26
Inventor 阳向波谢永平徐霞谢炜郑娟
Owner 成都三明药物研究所
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