Application of schisandra chinensis in the preparation of medicine for preventing and reducing toxic and side effect of antitumor agent

An antineoplastic drug, the technology of Schisandra chinensis, applied in the direction of antineoplastic drugs, drug combinations, pharmaceutical formulations, etc., can solve the problem of no toxic and side effects of anticancer drugs, achieve good clinical application prospects, good effects, and reduce toxic and side effects

Inactive Publication Date: 2007-02-28
胡汛 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Schisandra chinensis, the dry mature fruit of Schisandra chinensis (Turcz.) Baill. or Schisandra sphenanthera Rehd.et Wils. , Yiqi Shengjin, tonifying the kidney and calming the heart, is a nourishing and strong medicine commonly used in traditional Chinese medicine, and has a variety of pharmacological effects, but there are no reports of it preventing and reducing the side effects of anticancer drugs

Method used

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  • Application of schisandra chinensis in the preparation of medicine for preventing and reducing toxic and side effect of antitumor agent
  • Application of schisandra chinensis in the preparation of medicine for preventing and reducing toxic and side effect of antitumor agent
  • Application of schisandra chinensis in the preparation of medicine for preventing and reducing toxic and side effect of antitumor agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Preparation of Schisandra chinensis ethanol extract Percolation method: take 5000 g of Schisandra chinensis powder and use 6 times the amount of 95% ethanol to percolate, and the percolation speed is 15 ml / min. Recover the ethanol leachate, recover the ethanol under reduced pressure until there is no ethanol smell, concentrate to obtain an extract with a specific gravity of 1.15 g / ml, and set aside. The above ethanol can also be replaced by various alcohols such as methanol and propanol; other organic solvents such as ethyl acetate and ether solvents can also be used instead to prepare the Schisandra extract.

Embodiment 2

[0026] Example 2: Schizandra ethanol extract prevents and reduces the toxic and side effects of doxorubicin

[0027] 1 Materials and methods

[0028] 1.1 Drugs and reagents Doxorubicin hydrochloride for injection is available from Pharmacia, Italy, batch number: 5E2002-D. The ethanol extract of Schisandra chinensis prepared in Example 1 is dissolved in 0.5% poloxamer. CK (creatine kinase), CK-MB (creatine kinase isoenzyme-MB), lactate dehydrogenase (LDH), and aspartate transaminase (GOT) were detected by an automatic biochemical analyzer. Tissue protein extract, Pierce Company, USA. ICR male mice, weighing 25-30 g, were provided by Shanghai Experimental Animal Center.

[0029] 1.2 Test grouping and administration

[0030] 150 animals were randomly divided into 5 groups.

[0031] Blank control group: 24 rats, on the 1st to 3rd day of the experiment, intragastric administration of 20ml / kg / time of normal saline, 1 time / day, intraperitoneal injection once within 2 hours after ...

Embodiment 3

[0052] Example 3: Schizandra ethanol extract reduces cardiotoxicity caused by epirubicin

[0053] Experimental method: The ethanol extract of Schisandra chinensis obtained in Example 1 was prepared with 0.5% poloxamer to prepare a mother liquor of 8 g / ml. ICR mice were purchased from Shanghai Experimental Animal Center. Animals were divided into 2 groups, 15 in each group. Each mouse in group 1 was given 100 μl solvent (0.5% poloxamer) orally, and each mouse in group 2 was given 100 μl ethanol extract of Schisandra chinensis; 3 hours later, the mice were injected into the tail vein Epirubicin (4mg / kg); once every 7 days, 10 times in total. One week after the last dose, the mice were sacrificed, and the hearts were removed and fixed with 4% paraformaldehyde. After 48 hours, they were dehydrated with ethanol and fixed in paraffin. Sections of paraffin blocks (thickness 2 μm) were stained with toluidine blue and observed under a microscope. Cardiac injury was evaluated by the...

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Abstract

The invention relates to the use of schisandra fruit in preparing medicament for prevention and abatement of toxic and side effects of antineoplastic drugs including cardiovascular toxicity, liver toxicity, kidney toxicity, or bone marrow depression, or immunological suppression or trichomadesis.

Description

(1) Technical field [0001] The invention relates to the application of schisandra chinensis in the preparation of medicines for preventing and reducing the toxic and side effects of antineoplastic drugs. (2) Background technology [0002] Tumor is one of the main causes of human death, and tumor chemotherapy is a major means of treating tumors. However, antineoplastic drugs can cause many toxic and side effects. These side effects include cardiovascular toxicity, liver toxicity, nephrotoxicity, myelosuppression, immunosuppression, hair loss and so on. [0003] Schisandra chinensis, the dry mature fruit of Schisandra chinensis (Turcz.) Baill. or Schisandra sphenanthera Rehd.et Wils. , nourishing qi and promoting body fluid, tonifying the kidney and calming the heart, is a nourishing and strong medicine commonly used in traditional Chinese medicine, and has various pharmacological effects, but there is no report on preventing and reducing the toxic and side effects of antica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/57A61K45/00A61P9/00A61P35/00A61P43/00
Inventor 胡汛
Owner 胡汛
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