Nifuratel-nystatin vaginal gel and method for preparing same

A technology of nifuratel and vaginal gel, which is applied in the field of nifuratel-nystatin vaginal gel and its preparation, can solve the problems of unsatisfactory dissolution effect and limitations, and achieve rapid onset of effect and long-lasting effect Long, comfortable effect

Inactive Publication Date: 2007-03-14
张彤丽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the dosage forms of nifuratel-nystatin mainly include suppositories and vaginal soft capsules, but suppositories, vaginal soft capsules and vaginal ointments are limited due to their own shortcomings such as unsatisfactory greasy feeling and dissolving effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The main ingredients of Nifuratel-Nystatin vaginal gel are: Nifuratel-Nystatin (500 mg: 200,000 units) 420g, glycerin 280g, Carbomer 934 (Carboxgpolmethylene) 6g, sodium hydroxide 7g.

[0024] Preparation method: Add 280 g of glycerin to 420 g of nifuratel-nystatin (the ratio of nifuratel to nystatin is 500 mg: 200,000 units), and grind evenly.

[0025] Carbomer 934 with good spreadability and adhesion is used as the gelling agent. Weigh 6g of carbomer, slowly sprinkle or sieve the carbomer powder into 280g of deionized water whose temperature is not higher than room temperature prepared in advance, and stir while adding carbomer, the powder is completely added Soak for a period of time at room temperature until a colorless and transparent solution is formed. Add about 5g of sodium hydroxide dropwise to the prepared carbomer aqueous solution to adjust the pH to 5-7. Carbomer (carbomer) has a strong hydrophilicity, dry powder carbomer (carbomer) is very hygroscopic, l...

Embodiment 2

[0028] The ingredients of the nifuratel-nystatin vaginal gel are: 480 g of nifuratel-nystatin (500 mg: 20 force units), 300 g of glycerin, 8 g of carbomer 934, and 10 g of triethanolamine.

[0029] Add 300 g of glycerin to 480 g of nifuratel-nystatin (500 mg: 200,000 units), and grind evenly.

[0030] Weigh 8g of carbomer, slowly sprinkle or sieve the carbomer powder into 325g of deionized water whose temperature does not exceed room temperature prepared in advance, and stir while adding carbomer, the powder is completely added Soak for a period of time at room temperature until a colorless and transparent solution is formed. Add about 9g of sodium hydroxide dropwise to the prepared carbomer aqueous solution to adjust the pH to 5-7. Then add the prepared gel matrix solution into the suspension of nifuratel-nystatin and glycerin, stir evenly, add dropwise a small amount (about 1g) of sodium hydroxide and stir well, neutralize to form a gel, and control pH6-7, detection of int...

Embodiment 3

[0032] The main ingredients of Nifuratel-Nystatin vaginal gel are: Nifuratel-Nystatin (500 mg: 200,000 units) 580g, glycerin 400g, Carbomer 934 (Carboxgpolmethylene) 8g, triethanolamine 10g .

[0033] Preparation method: Add 400 g of glycerin into 580 g of nifuratel-nystatin (500 mg: 200,000 units), and grind evenly.

[0034] Weigh 8g of carbomer, slowly sprinkle or sieve the carbomer powder into 330g of deionized water whose temperature is not higher than room temperature prepared in advance, and stir while adding carbomer, the powder is completely added Soak for a period of time at room temperature until a colorless and transparent solution is formed. Add about 10 g of sodium hydroxide dropwise to the prepared carbomer aqueous solution to adjust the pH to 6-7. Then add the prepared gel matrix solution into the suspension of nifuratel-nystatin and glycerin, stir evenly, neutralize to form a gel, detect the intermediate, measure the pH value and content, pack and pack into ...

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PUM

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Abstract

The invention discloses a vaginal gel which is prepared from the following raw materials: Nifuratel and Nysfungin 300-600 parts, glycerin 200-400 parts, gel base material 100-500 parts. The preparing process consists of steps of abrading homogeneously, charging charging base materials into turbid liquor and stirring homogeneously, and adjusting pH to be 6-7.

Description

technical field [0001] The invention belongs to the field of chemical medicine and pharmacy, and in particular relates to a nifuratel-nystatin vaginal gel and a preparation method thereof. Background technique [0002] Nystatin is an antibiotic with fungicidal activity, especially its effect on Candida fungi is more significant. Nifuratel is a nitrofuran derivative and a broad-spectrum antibiotic, especially for common pathogens of gynecological infections such as Gram-positive and negative bacteria, trichomonads, molds, chlamydia and mycoplasma. It has no inhibitory effect on beneficial bacteria Lactobacillus. There is no negative interaction between the two components. In order to treat the increasingly common mixed vaginal infections (Candida, Trichomonas and bacteria), the original organism cannot be diagnosed or can not be diagnosed in time, so as to prevent superinfection of mold As well as relapse after other drug treatments, both provided a more complete effect. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K9/00A61K47/10A61K47/36A61K47/38A61K47/42A61P15/02A61P31/10A61K31/422
Inventor 张彤丽余印祥
Owner 张彤丽
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