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The preparation of compound digestive enzyme and its preparation method

A compound digestive enzyme preparation and digestive enzyme technology, which is applied in the field of pharmaceutical dosage forms and preparations, can solve the problems of unevenness, large diameter of multi-enzyme tablets, low enzyme release rate, etc., and achieve the effect of improving digestibility

Active Publication Date: 2007-04-11
CHANGZHOU QIANHONG BIOPHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, multienzyme tablets have the following defects due to their large diameter (generally more than 6 mm) and small specific surface area: the one is that the multienzyme tablets are mixed with food in the gastrointestinal tract with inhomogeneity, and the second is that after the multienzyme tablets are mixed with food It will delay entering the duodenum through the pylorus, and the third is the low rate of enzyme release

Method used

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  • The preparation of compound digestive enzyme and its preparation method

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Effect test

Embodiment 1

[0015] The composition and ratio of the compound digestive enzyme preparation of this embodiment are shown in Table 1.

[0016] Element

Ratio(%)(w / w)

Enteric-coated digestive enzyme pellet core

trypsin

64.5

Hydroxypropylmethylcellulose

6.5

Enteric coating layer

Enteric coating material

16.1

Gastric digestive enzyme layer

Pepsin

4.8

carboxymethyl cellulose

1.6

Gastric coating layer

Gastric coating material

6.5

[0017] The preparation steps of the compound digestive enzyme preparation of the present embodiment are as follows:

[0018] ①Put 800g of trypsin powder and 80g of hydroxypropyl methylcellulose into the wet granulator, stir and mix evenly. Add the ethanol solution of 480ml65wt% then, stir and make wet material;

[0019] ②Put the wet material prepared in step ① into an extrusion cutting granulator (the aperture of the screen is 0.3-2.5mm, usually 0.9...

Embodiment 2～ Embodiment 4

[0023] The remainder of embodiment 2~embodiment 4 is identical with embodiment 1, and difference is each constituent and ratio (seeing table 2) of compound digestive enzyme preparation, used adjuvant of preparation process, solvent and their consumption (seeing table 3 ).

[0024] Example 2

[0025] Example 2

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Abstract

The invention discloses a kind of compound digestive enzyme preparation and its preparation method. The said enzyme preparation is a kind of microcapsules, and was composed of enteric dissolvable digestive enzyme pellets core, its coat, gastric dissolvable digestive enzyme layer and coat of it. Its preparation comprises steps of: (1)blend enteric coated digestive enzymes with accessories, then add solvent, churn up to form wet material; (2)the wet material was shoved ,cut, rolled to form a globose wet grains, dried and the enteric dissolvable digestive enzyme pellets core was screened out; (3)sprinkle solutions of enteric dissolvable coating material on it ,drying to get the enteric dissolvable digestive enzyme pellets core; (4)sprinkle gastric dissolvable digestive enzyme solutions to the core ,then sprinkle the solutions of gastric dissolvable coating material , desiccate and screen out the microcapsules. The compound digestive enzyme preparation has a high enzyme release rate and good effect on therapy in practice.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical dosage forms and preparations, in particular to the improvement of dosage forms of digestive enzyme preparations. Background technique [0002] Pepsin is extracted from the gastric mucosa of pigs, cattle, sheep and other animals. Pepsin can hydrolyze protein into peptone. Pancreatin is a mixture of various digestive enzymes such as trypsin, pancreatic amylase, and pancreatic lipase extracted from the pancreas of pigs, cattle, and sheep. Trypsin can hydrolyze protein into peptone and corresponding short peptides. Pancreatic amylase breaks down starch into dextrins and sugars, and pancreatic lipase breaks down fats into glycerol and fatty acids. Amylase is mainly obtained through microbial fermentation, which can directly decompose starch into easily absorbed dextrin and maltose, and is usually used as a component of digestive enzyme preparations. Cellulase is mainly obtained through micro...

Claims

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Application Information

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IPC IPC(8): A61K38/48A61K38/47A61K9/16A61P1/14
Inventor 刘军盛甜
Owner CHANGZHOU QIANHONG BIOPHARMA
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