Aciclovir high-molecular hydrogel dressing and its preparation method
A polymer hydrogel and a technology for preparing solutions, which are applied to the active ingredients of heterocyclic compounds, medical science, bandages, etc., can solve the problems of difficult control of dosage, poor oral absorption, and contaminated clothes, etc. Controllable, convenient administration, and increased exposure time
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Embodiment 1
[0026] (1) Prepare solution A: fully dissolve 0.025g N,N'-methylenebisacrylamide in 3.5g acrylic acid at room temperature;
[0027] (2) Prepare solution B: dissolve 1 g of acyclovir powder in 10 mL of aqueous sodium hydroxide solution (0.22 g / mL);
[0028] (3) Prepare solution C: Mix 2.5mL polyvinyl alcohol aqueous solution (0.1g / mL), 3mL glycerin, 2mL potassium persulfate aqueous solution (0.02g / mL), and 1-2ml water until fully dissolved;
[0029] (4) Slowly add solution A to solution B dropwise, adjust the pH of the system to 6, add solution C and a small amount of cooling agent after fully reacting, stir evenly, pour into the mold, heat at 50°C to polymerize and cross-link to obtain acithin Lowe polymer hydrogel dressing.
[0030] (5) Cover both sides of the dressing with non-woven fabric and anti-adhesive film respectively.
[0031] Treated herpes zoster for 20 patients, 19 of them relieved in 1 day and recovered in 3 days, and 20 of them had no side effects.
Embodiment 2
[0033] (1) Preparation of solution A: fully dissolve 0.02g of N,N'-methylenebisacrylamide in 5g of acrylic acid at room temperature;
[0034] (2) Prepare solution B: dissolve 1.5 g of acyclovir powder in 15 mL of aqueous sodium hydroxide solution (0.2 g / mL);
[0035] (3) Prepare solution C: Mix 3mL polyvinyl alcohol aqueous solution (0.1g / mL), 3mL glycerin, 2mL potassium persulfate aqueous solution (0.02g / mL), and 1-2ml water until fully dissolved;
[0036] (4) Slowly add solution A to solution B dropwise, adjust the pH of the system to 6.5, add solution C and a small amount of cooling agent and penetration enhancer after fully reacting, stir evenly, pour into the mold, heat and polymerize at 55°C Lian Ji get acyclovir polymer hydrogel dressing.
[0037] (5) Cover both sides of the dressing with non-woven fabric and anti-adhesive film respectively.
[0038] Treated herpes zoster for 20 patients, 19 of them relieved in 1 day and recovered in 3 days, and 20 of them had no side...
Embodiment 3
[0040] (1) Prepare solution A: fully dissolve 0.03g of N,N'-methylenebisacrylamide in 4g of acrylic acid at room temperature;
[0041] (2) Prepare solution B: dissolve 2 g of acyclovir powder in 15 mL of aqueous sodium hydroxide solution (0.22 g / mL);
[0042] (3) Preparation of solution C: Mix 5mL polyvinyl alcohol aqueous solution (0.1g / mL), 5mL glycerin, 2mL potassium persulfate aqueous solution (0.02g / mL), and 1-2ml water until fully dissolved;
[0043] (4) Slowly add solution A to solution B dropwise, adjust the pH of the system to 7, add solution C and a small amount of cooling agent after fully reacting, stir evenly, pour it into a mold, heat at 60°C to polymerize and cross-link to obtain acithin Lowe polymer hydrogel dressing.
[0044] (5) Cover both sides of the dressing with non-woven fabric and anti-adhesive film respectively.
[0045] Treated herpes zoster for 20 patients, 19 of them relieved in half a day, recovered in 3 days, and 20 had no side effects.
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