Asiatic moonseed drop pills and preparation method thereof

A technology of Beidougen and root dripping pills, which can be applied in the fields of pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of low bioavailability, unstable quality, long disintegration time limit, etc., and achieve biological High utilization, good drug stability, and the effect of improving bioavailability

Inactive Publication Date: 2007-07-04
陈茜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the characteristics of conventional preparation technology, such oral preparations have long disintegration time, poor absorption, slow onset, and low bioavailability, which affect the full play of drug efficacy.
At the same time, it is easy to split, change color, absorb moisture, etc. during storage, and the quality is unstable

Method used

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  • Asiatic moonseed drop pills and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: get the northern bean root medical material, be pulverized into coarse powder. Take 1000g of northern bean root coarse powder, add water and decoct twice, the amount of water added is 8 times the amount for the first time, and 6 times the amount for the second time, the decoction time is 2 hours for the first time, 1 hour for the second time, filter; combine 2 filtrates, concentrate to a relative density of 1.20 (60°C), add ethanol to make the alcohol content 70%, stir evenly, let stand for 12 hours, centrifugal filter, take the supernatant to recover ethanol, concentrate to a relative density of 1.20~ 1.25 (20°C) extract, vacuum-dry or spray-dry the extract to obtain the extract. Take the extract, crush it, and pass through a 100-mesh sieve. Pepper root extract by weight ratio: polyethylene glycol 6000 =1:2 ratio, add to the melted matrix (90°C), stir evenly, drop into simethicone coolant (3°C), separate drop pills, absorb the coolant, dry to obtain.

Embodiment 2

[0018] Embodiment two: get the northern bean root medical material, be pulverized into coarse powder. Take 1000g of northern bean root coarse powder, add water and decoct twice, the amount of water added is 8 times the amount for the first time, and 6 times the amount for the second time, the decoction time is 2 hours for the first time, 1 hour for the second time, filter; combine 2 filtrates, pass the filtrate through the treated and filled macroporous adsorption resin column, resin type D101, first elute with 1 times the column volume of water, discard the eluent, and then use 4 times the column volume of 70% ethanol The extract adsorbed on the macroporous resin is eluted, the eluent is recovered with ethanol, concentrated to an extract with a relative density of 1.20-1.25 (20°C), and the extract is vacuum-dried to obtain an extract. Get extract, pulverize, cross 100 mesh sieves, be the root extract of bean root by weight: the ratio of mixed matrix=1: 1.5 (mixed matrix is ​​...

Embodiment 3

[0019] Example 3: In this example, the roundness, difference in pill weight, hardness, dissolution time and other indicators are investigated through the formulation of the root extract of the bean root and different matrixes, so as to determine the weight ratio of the extract to a single or mixed matrix.

[0020] Trials of Beidou root extract and different matrix formulations (extracts are 1 part)

[0021]

[0022] Note: 1. The coolant is simethicone oil or liquid paraffin, and the cooling temperature is 3-5°C; the temperature of the heat preservation of the drug material and the dripper is 85-90°C; the dripping speed is 30-50 capsules / min.

[0023] 2. The above results show that all the indicators of No. 4, 5, 6, 7, and 8 tests are good, that is, when the ratio of the extract to the matrix is ​​1:1-1:5, it can be dripped smoothly. However, considering the dosage and other factors, the preferred ratio is Test Nos. 4, 5, 6, and 8, that is, the ratio of the extract to the ma...

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PUM

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Abstract

The invention relates to a dripping pill of subprostrate sophora root and process for preparation, wherein the medicament has the functions of heat clearing, detoxicating, dispelling wind, relieving pain, anti-inflammation and relieving sore-throat, which can be used for treating throat pain, acute pharyngitis and tonsillitis. The medicament is prepared from Chinese medicinal herb of subprostrate sophora root through extracting and mixing extractive with dripping pill base materials. The invention can achieve high bioavailability, better pharmaceutical stability, smaller volume, convenience in administration and carrying. The medicament also has the advantages of quicker disintegration and dissolution, higher dissolution, quick-speed medicine release, quick-speed effect, simple process for manufacturing, and low cost.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a Beidougen dripping pill and a preparation process thereof. Background technique [0002] Beidougen is the dry rhizome of Menispermum dauricum DC., a plant of the genus family. It is also known as Huangxiangtiao, wild bean root, and bat vine. It grows in mountain shrubs or climbs on rocks. Mainly produced in Northeast China, North China and Shaanxi. Its main active ingredients are dauricine, menisperine, daurinoline and so on. It has the effects of clearing heat and detoxifying, expelling wind and relieving pain, reducing swelling and relieving throat, and is clinically used to treat sore throat, acute pharyngitis, tonsils, etc. Modern pharmacological studies have shown that the total alkaloids of bean root have antibacterial, anti-inflammatory, analgesic, immune function-enhancing, and anti-arrhythmic effects. Studies have also shown...

Claims

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Application Information

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IPC IPC(8): A61K36/59A61K9/20A61P11/04
Inventor 陈茜滕慧丽
Owner 陈茜
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