Removable tip for laser device with transparent lens

Inactive Publication Date: 2005-01-13
TRANSMEDICA INT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention employs a laser to perforate or alter the skin of a patient so as to remove fluids, gases or other biomolecules or to administer anesthetics or other pharmaceuticals. Perforation or alteration is produced by irradiating the surface of the target tissue with a pulse or pulses of electromagnetic energy fro

Problems solved by technology

These procedures have many drawbacks, including the possible infection of health care workers and the public by the sharp device used to perforate the skin, as well as the cost of handling and disposal of biologically hazardous waste.
If the patient is infected with blood-born agents, such as human immunodeficiency virus (HIV), hepatitis virus, or the etiological agent of any other diseases, the contaminated sharp poses a serious threat to others that might come in contact with it.
Post-use disposal of contaminated sharps imposes both logistical and financial burdens on the end user.
These costs are imposed as a result of the social consequences of improper disposal.
For example, in the 1980's improperly disposed biological wastes washed up on public beaches on numerous occasions.
Improper disposal also permits others, such as intravenous drug users, to obtain contaminated needles and spread dis

Method used

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  • Removable tip for laser device with transparent lens
  • Removable tip for laser device with transparent lens
  • Removable tip for laser device with transparent lens

Examples

Experimental program
Comparison scheme
Effect test

Example

EXAMPLE 1

The laser comprises a flashlamp (PSC Lamps, Webster, N.Y.), an Er:YAG crystal (Union Carbide Crystal Products, Washagoul, Wash.), optical-resonator mirrors (CVI Laser Corp., Albuquerque, N. Mex.), an infrared transmitting lens (Esco Products Inc., Oak Ridge, N.J.), as well as numerous standard electrical components such as capacitors, resistors, inductors, transistors, diodes, silicon-controlled rectifiers, fuses and switches, which can be purchased from any electrical component supply firm, such as Newark Electronics, Little Rock, Ark.

Example

EXAMPLE 2

An infrared laser radiation pulse was formed using a solid state, pulsed, Er:YAG laser consisting of two flat resonator mirrors, an Er:YAG crystal as an active medium, a power supply, and a means of focusing the laser beam. The wavelength of the laser beam was 2.94 microns. Single pulses were used.

The operating parameters were as follows: The energy per pulse was 40, 80 or 120 mJ, with the size of the beam at the focal point being 2 mm, creating an energy fluence of 1.27,2.55 or 3.82 J / cm2. The pulse temporal width was 300 μs, creating an energy fluence rate of 0.42, 0.85 or 1.27×104 W / cm2.

Transepidermal water loss (TEWL) measurements were taken of the volar aspect of the forearms of human volunteers. Subsequently the forearms were positioned at the focal point of the laser, and the laser was discharged. Subsequent TEWL measurements were collected from the irradiation sites, and from these the measurements of unirradiated controls were subtracted. The results (shown i...

Example

EXAMPLE 3

An infrared laser radiation pulse was formed using a solid state, pulsed, Er:YAG laser consisting of two flat resonator mirrors, an Er:YAG crystal as an active medium, a power supply, and a means of focusing the laser beam. The wavelength of the laser beam was 2.94 microns. A single pulse was used.

The operating parameters were as follows: The energy per pulse was 60 mJ, with the size of the beam at the focal point being 2 mm, creating an energy fluence of 1.91 J / cm2. The pulse temporal width was 300 μs, creating an energy fluence rate of 0.64×104 W / cm2.

The volar aspect of the forearm of a volunteer was placed at the focal point of the laser, and the laser was discharged. After discharge of the laser, the ablated site was topically administered a 30% liquid lidocaine solution for two minutes. A 26G-0.5 needle was subsequently inserted into the laser ablated site with no observable pain. Additionally, after a 6-minute anesthetic treatment, a 22G-1 needle was fully inser...

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PUM

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Abstract

The present invention provides an improved method of removing fluids, gases or other biomolecules, or delivering a pharmaceutical composition, through the skin of a patient without the use of a sharp or needle. The method includes the step of irradiating the stratum corneum, an applied pharmaceutical or an absorbing material, using a laser. By selection of parameters, the laser irradiates the selected material or tissue to create pressure gradients, plasma, cavitation bubbles, or other forms of tissue ablation or alteration. These methods increase the diffusion of pharmaceuticals into, or fluids, gases or other biomolecules out of, the body. For this invention, a pharmaceutical composition can be applied to the skin before or after laser irradiation.

Description

FIELD OF THE INVENTION This invention is in the field of medical procedures, namely laser medical equipment used in the delivery of anesthetics or pharmaceuticals to, or the removal of fluids, gases or other biomolecules from, a patient. BACKGROUND The traditional method for the collection of small quantities of fluids, gases or other biomolecules from a patient utilizes mechanical perforation of the skin with a sharp device such as a metal lancet or needle. Additionally, the typical method of administering anesthetics or other pharmaceuticals is through the use of a needle. These procedures have many drawbacks, including the possible infection of health care workers and the public by the sharp device used to perforate the skin, as well as the cost of handling and disposal of biologically hazardous waste. When skin is perforated with a sharp device such as a metal lancet or needle, biological waste is created in the form of the “sharp” contaminated by the patient's blood and / or ...

Claims

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Application Information

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IPC IPC(8): A61B5/145A61B10/00A61B17/00A61B17/34A61B18/00A61B18/20A61B19/00A61M37/00A61N5/06
CPCA61B5/411A61B5/15138A61B18/20A61B18/203A61B2010/008A61B2017/00057A61B2017/00765A61B2018/00452A61B2019/545A61B2218/008A61M37/00A61M2037/0007H04R25/75A61B5/1411A61B5/150022A61B5/150076A61B5/150099A61B17/3476A61B2090/395
Inventor MARCHITTO, KEVIN S.FLOCK, STEPHEN T.
Owner TRANSMEDICA INT
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