Compositions For Wound Treatment
a composition and wound technology, applied in the field of compositions for wound treatment, can solve the problems of collagen as a component of wound dressings, prone to denaturation, and added cost, and achieve the effect of reducing antigenic response and cos
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reference example 1
llagen / Fibrous ORC Sponge
[0064]A freeze-dried collagen / ORC sponge is prepared as follows.
[0065]First, the collagen component is prepared from bovine corium as follows. Bovine corium is split from cow hide, scraped and soaked in sodium hypochlorite solution (0.03% w / v) to inhibit microbial activity pending further processing. The corium is then washed with water and treated with a solution containing sodium hydroxide (0.2% w / v) and hydrogen peroxide (0.02% w / v) to swell and sterilize the corium at ambient temperature. The corium splits then undergo an alkali treatment step in a solution containing sodium hydroxide, calcium hydroxide and sodium bicarbonate (0.4% w / v, 0.6% w / v and 0.05% w / v, respectively) at pH greater than 12.2, ambient temperature, and for a time of 10-14 days, with tumbling, until an amide nitrogen level less than 0.24 mmol / g is reached. The corium splits then undergo an acid treatment step with 1% hydrochloric acid at ambient temperature and pH 0.8-1.2. The treatme...
reference example 2
lginate / Fibrous ORC Sponge
[0069]An alginate / fibrous ORC sponge was prepared as described in Reference Example 1, but with replacement of the collagen by an equal weight fraction of alginate
[0070]Sodium alginate was obtained from Pronova Biomedical in a powdered form. The powder was dissolved in ice cold water at a concentration of 2% w / v by mixing with a paddle stirrer. The solution was then diluted to 1% solids by the addition of an equal volume of 0.1 M acetic acid. A known weight of the sodium alginate solution was then added to the ORC to give a final ratio of 45%ORC / 55% sodium alginate in the final material. The sponges were then prepared as in example 1.
reference example 3
aluronate / Fibrous ORC Sponge
[0071]A hyaluronate / fibrous ORC sponge was prepared as described in Reference Example 1, but with replacement of the collagen by an equal weight fraction of alginate.
[0072]Sodium Hyaluronate with an average molecular weight distribution of 500,000 daltons was obtained from Lifecore Biomedical Inc. in a powdered form. The powder was dissolved in ice cold water at a 2% w / v concentration with mixing overnight. A known weight of the sodium hyaluronate solution was then added to the ORC to give a final ratio of 45%ORC / 55% sodium hyaluronate in the final material. The sponges were then prepared as in example 1.
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