38 results about "Lipoprotein particle" patented technology

Methods, reports and systems for generating insulin resistance indexes for assessing decreased insulin sensitivity and/or levels of insulin resistance using a plurality of different measured lipoprotein particle parameters.

Methods, computer program products and apparatus determine a subject's risk of having or developing CHD using a calculated HDL particle risk number and/or a mathematical model of risk associated with HDL particles that adjusts concentrations of at least one of the subclasses of small, medium and large HDL particle measurements to reflect predicted CHD risk. A calculated LDL particle risk number may also be generated as well as a lipoprotein particle index derived from the ratio of R_LDL/R_HDL.

Nanostructures for the systemic delivery of nucleic acids, such as RNA, are provided herein. The nanostructures include templated lipoprotein nanoparticles (TLPs) composed of a core decorated with proteins, a lipid bilayer and hydrophobic molecules that self-assemble with nucleic acids, such as RNA. The nanostructures are useful for research, therapeutic and diagnostic applications.

The process of producing active protein and oil with maggot and earthworm as material belongs to the field of feed producing technology. The automatic production process can produce full protein powder, granular full protein product, defatted protein powder, defatted granular protein product and separated maggot or earthworm oil. The production process can maintain the activity of the protein, amino acids and other active matter unchanged, raise the biological potency and digesting and absorbing rate of the products. The present invention also provides relevant large scale production process.

A method for determining the molar concentration of specific lipoprotein particles present in a bodily fluid is presented. Multipixel Capillary Isotachophoresis Laser Induced Fluorescence is applied to fluorescently-labeled lipoproteins or immunologically-labeled apolipoproteins, facilitating quantification of lipoproteins and/or lipid particles and/or their associated apolipoproteins in a sample. The measurements are used to predict the risks of developing, progressing in severity of diseases related to lipoprotein particles, including cardiovascular and metabolic disorders.

The invention relates to a detection system used for simultaneously detecting lipoprotein sub-fraction cholesterol and lipoprotein particle concentration. The detection system is characterized in thatthe system comprises a sample container, a reagent container, a cleaning fluid container, a reaction module, a first detection module and a second detection module; the sample container is connectedto the inlet pipeline of the first detection module through a pipeline; the cleaning liquid container is connected to a pipeline which is connected with the sample container and the first detection module through a pipeline; the outlet of the first detection module is connected with the inlet of the reaction module through a pipeline; the reagent container is connected to a pipeline which is connected with the first detection module and the reaction module through a pipeline; and the outlet end of the reaction module is connected with the second detection module. With the detection system adopted, lipoprotein cholesterol sub-fractions can be detected, and lipoprotein particle concentration can be also detected; and since the detection system does not need to perform detection twice, and time and cost are saved.

A concentration of cholesterol ester or free cholesterol can be calculated using the concentrations of total cholesterol and triglyceride in lipoproteins contained in a sample. Further, a concentration of lipoprotein particles in a fraction can be calculated using the lipoprotein particle size in the fraction. The concentrations of total cholesterol and triglyceride contained in a subject sample are detected. Using the concentrations of total cholesterol and triglyceride thus detected, the concentration of cholesterol ester or free cholesterol is calculated. Further, using the concentration of cholesterol ester or free cholesterol thus calculated, the concentration of lipoprotein particles in a fraction can be calculated.

This application describes a method for measuring the molar concentrations of lipoprotein particles and lipoprotein subclass particles in bodily fluid by Multipixel Capillary Isotachophoresis Laser Induced Fluorescence (MPCE-ITP-LIF) and compositional analysis of spherical lipoprotein particles. The ability to measure several kinds of lipoproteins and particles in one unified system provides a useful diagnostic tool for predicting the risk of developing metabolic diseases such as cardiovascular disease and cardiodiabetes.

The present invention relates to a novel lipoprotein particle, methods for preparing and purifying the same, its use in medicine, particularly in the prevention of malarial infections, compositions/vaccines containing the particle or antibodies against the protein particle such as monoclonal or polyclonal antibodies and use of the same, particularly in therapy. In particular it relates to an immunogenic protein particle comprising the following monomers:

• • a. a fusion protein comprising sequences derived from a CS protein of P. vivax and the S antigen of Hepatitis B (CSV-S), and
  • b. a fusion protein comprising sequences derived from CS protein of P. falciparum and S antigen of Hepatitis B (RTS), and
  • c. optionally the S antigen derived from Hepatitis B.

This invention relates to methods for assessing quantities of spherical or substantially spherical lipoprotein particles or portions thereof present in a biological sample based on the measurement of free cholesterol and/or phospholipid content in the lipoprotein particles. The invention also relates to the use of the assessed quantities of the lipoprotein particles or portions thereof to determine whether a subject is at increased risk for cardiovascular diseases and cardiodiabetes.

The invention relates to a process for preparing saposin lipoprotein particles, comprising a saposin-like protein, lipids and optionally a hydrophobic agent wherein the saposin-like protein or the hydrophobic agent is selectively bound to a support to allow the self-assembly of the saposin lipoprotein particles. The process of the invention comprises the step of a.) providing the hydrophobic agent and lipids, b. 1)/b.2 contacting the hydrophobic agent or the saposin-like protein with a support that is capable of selectively binding either of the two molecules to the support, c.1)/c.2) contacting the support-bound particle components with the remaining particle components, either the saposin-like protein or the hydrophobic agent, to allow for the self-assembly of the saposin lipoprotein particle on the support and d.) optionally eluting the support-bound saposin lipoprotein particles.

The invention discloses a reagent for detecting the concentration of lipoprotein particles, the reagent is composed of the following components: a diluent, a density solution and a buffer solution, wherein the density solution contains an alcohol substance, and the concentration of the alcohol substance is 0.1%-50%. The invention belongs to the field of in vitro diagnosis. The reagent for detecting the concentration of the lipoprotein particles provided by the invention not only can be used for independently detecting the concentration of the protein particles, but also can be used together with other instrument reagents for detecting subcomponents of lipoprotein cholesterol at the same time without twice detection, so that the time and the cost are saved, and the reagent has a relatively high commercial value, can be widely applied to clinical examination and scientific research experiments.