The invention discloses a molecular marker related to prostate cancer, wherein the molecular marker is LOC100128675. The invention further discloses a diagnostic kit for the prostate cancer and an application of the molecular marker to screening, diagnosis, therapy, monitoring and prognosis for prostate cancer high-risk groups. The diagnostic kit comprises the molecular marker LOC100128675 related to the prostate cancer. By the aid of the molecular marker and the diagnostic kit comprising the molecular marker for detecting the prostate cancer, early detection can be rapidly and effectively realized, and therapeutic targets and important basis are provided for clinical application of gene therapy, drug therapy and the like.