Cephalosporin analog antibiotic preparation method

A cephalosporin and halogen technology, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, active ingredients of nitro compounds, etc., can solve the problems of environmental pollution of chemical substances, low total product yield, complex reactions, etc., and achieve The effect of reducing reaction steps, high purity of raw materials, and improvement of total yield
CN100361996CInactive Publication Date: 2008-01-16ZHEJIANG ZHENYUAN PHARMA CO LTD +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG ZHENYUAN PHARMA CO LTD
Publication Date
2008-01-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to new method of preparing cephalo antibiotic. The new preparation process includes first acidylating the C7 place of initial material 7-amino-3-methylol cephaloalkanoic acid, the subsequent esterifying the C2 place carboxyl radical with corresponding ester radical, and final functionating the C3 place of the product. The process of the present invention has less reaction steps, raised total synthesis efficiency, low cost and reduced environmental pollution.
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Description

technical field

[0001] The invention relates to a preparation method of cephalosporin antibiotics. Background technique

[0002] Currently on the market, the cephalosporin antibiotics for clinical application are all semi-synthetic cephalosporins, except for 7-ADCA (1) series of oral cephalosporins such as Cefalexin (Cefalexin) (1a), Cefadroxil (Cefadroxil) ( 1b), cephradine (Cephradine) (1c), cefetamet pivoxil (Cefetamet pivoxil) (1d), etc., and cephalosporins with a methyl acetate group in the C3-position of the 7-ACA (2) series such as cephalosporins Except for Cephalothin (2a), Cefotaxime (2b), and Cefathiamidine (2c), all other cephalosporins are cephalosporins with different group substitutions at the C3-position Bacteria, which can be broadly divided into:

[0003] 1. Cephalosporins substituted with a thiomethyl group at the C3-position, such as Cefazoline (3a), Cefoperazone (3b), Ceftriaxone (3c), etc.;

[0004] 2. Cephalosporins substituted with a nitrogen-contai...

Claims

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