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Coated norcantharidin tablet and its preparing method

A technology of norcantharidin and norcantharidin tablets is applied in the field of film-coated tablets and their preparation, and can solve the problem of no patent application for norcantharidin film-coated tablets, uneven color of sugar-coated tablets, and long production time of sugar-coated tablets, etc. problems, to achieve the effect of improving bioavailability, improving appearance, and stable properties of the main drug

Inactive Publication Date: 2008-05-07
山东山大康诺制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although sugar-coated tablets are easy for patients to take and have a better taste, the weight of the embryo tablet is increased by coating the sugar-coated tablet, which consumes more materials. At the same time, the drying speed is slow during the production process, and the prolonged heating time of the drug will affect the quality of the drug; in addition, the sugar-coated tablet is easy to Mildew, easy to soften, easy to absorb moisture and disintegrate; at the same time, the color of sugar-coated tablets is uneven, which may easily cause unclear labels; moreover, the production of sugar-coated tablets takes a long time and the production cost is relatively high
[0004] In recent years, tablet film coating has become the development direction of pharmaceuticals, and its use in drug production has attracted the attention of the pharmaceutical industry. Patent applications for inventions related to film coating have gradually increased, but so far, there has been no patent application for norcantharidin film coating tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Preparation of oblate norcantharidin tablets with a diameter of 0.5 to 0.6 cm: (1) crushing and sieving: the principal ingredient norcantharidin is passed through 100 mesh, sucrose is crushed and passed through 100 mesh, starch is passed through a 100 mesh sieve, hardened Magnesium fatty acid is crossed 40 mesh sieves; (2) granulation: with described weight ratio, take gram as unit, take by weighing following each component respectively: norcantharidin 30 grams, starch 60 grams, sucrose 50 grams, The mass percentage is 70 grams of 10% starch paste, 2 grams of magnesium stearate, and 3 grams of talcum powder; firstly, after mixing sucrose and starch with norcantharidin, adding the mass percentage is 10% water-soluble starch paste; 30° C. Mix at ~33°C to make a soft material that meets the granulation requirements, and then granulate; (3) Drying and granulation: put the wet granules in an oven to dry (40-50°C), and the total drying time is 2 (4) mixing: adding magnesium s...

Embodiment 2

[0027] Preparation of oblate norcantharidin tablets with a diameter of 0.6 to 0.7 cm: (1) crushing and sieving: the principal ingredient norcantharidin is passed through 100 mesh, sucrose is crushed and passed through 100 mesh, starch is passed through a 100 mesh sieve, hardened Magnesium fatty acid is crossed 40 mesh sieves; (2) granulation: with described weight ratio, take gram as unit, take by weighing following each component respectively: norcantharidin 25 grams, starch 30 grams, sucrose 30 grams, The mass percent is 45 grams of 10% starch paste, 0.8 grams of magnesium stearate, and 1.2 grams of talcum powder; after first mixing sucrose and starch with norcantharidin, adding mass percent is 10% water-soluble starch paste; 28 ℃ Mix at ~30°C to make a soft material that meets the requirements of granulation, and then granulate; (3) Drying and granulation: put the wet granules in an oven to dry (40-50°C), and the total drying time is 2 (4) mixing: adding magnesium stearate ...

Embodiment 3

[0030]Preparation of oblate norcantharidin tablets with a diameter of 0.7 to 0.8 cm: (1) crushing and sieving: the principal ingredient norcantharidin is passed through 100 mesh, sucrose is crushed and passed through 100 mesh, starch is passed through a 100 mesh sieve, hardened Magnesium fatty acid crosses 40 mesh sieves; (2) granulation: with described weight ratio, take gram as unit, take by weighing following each component respectively: 40 grams of norcantharidin, 80 grams of starch, 80 grams of sucrose, Mass percentage is 100 grams of 10% starch paste, 8 grams of magnesium stearate, 10 grams of talcum powder; after first mixing sucrose and starch with norcantharidin, adding mass percentage is 10% water-soluble starch paste; 37 ℃ Mix at ~40°C to make a soft material that meets the requirements of granulation, and then granulate; (3) Drying and granulation: put the wet granules in an oven to dry (40-50°C), and the total drying time is 2 (4) mixing: adding magnesium stearate...

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Abstract

The coated norcantharidin tablet has one norcantharidin tablet of 0.5-0.8 cm diameter and one surface coating of 0.3-1.0 mm thickness. It is prepared through preparing norcantharidin tablet and forming moisture-proof coating. The coated norcantharidin tablet has high moisture-proof property, high stability, high medicine leaching rate, high bioavailability and high clinical treating effect. It is used in treating liver cancer, esophageal cancer, leucopenia, hepatitis, etc. and may be also used as pre-operational medicine or in combined chemotherapy.

Description

technical field [0001] The invention relates to a film-coated tablet and a preparation method thereof, in particular to a film-coated tablet of norcantharidin tablets and a preparation method thereof. Background technique [0002] Norcantharidin Tablets are suitable for liver cancer, esophageal cancer, stomach and cardia cancer, leukopenia, hepatitis, liver cirrhosis, and hepatitis B virus carriers. Restricted use for diabetics. [0003] Commercially available norcantharidin tablets are mostly sugar-coated tablets. Although sugar-coated tablets are easy for patients to take and have a better taste, the weight of the embryo tablet is increased by coating the sugar-coated tablet, which consumes more materials. At the same time, the drying speed is slow during the production process, and the prolonged heating time of the drug will affect the quality of the drug; in addition, the sugar-coated tablet is easy to Mildew, easy to soften, easy to absorb moisture and disintegrate; a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61K9/28A61P35/00A61P1/16A61P31/20
Inventor 冯军涛刘建峰赵桂森李思林
Owner 山东山大康诺制药有限公司
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