Low hemolytic antibacterial peptide and its application

A peptide, antibacterial activity technology, applied in the field of antibacterial peptides, can solve problems such as limiting the development of treatment, achieve the effect of inhibiting growth, improving compatibility, treating or preventing bacterial or viral infection
CN100390194CInactive Publication Date: 2008-05-28PACGEN BIOPHARMLS
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
PACGEN BIOPHARMLS
Publication Date
2008-05-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

An antibacterial with cyclic short chain and low hematolysis has the chemical formula (A1X1A2)N and unique amino acid structure with benzene ring and positive charge.
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Description

technical field

[0001] The invention relates to an antibacterial peptide, especially a short peptide with a ring structure and only composed of 9 benzene rings and positively charged amino acids. The peptide has excellent antibacterial ability. Compared with other long peptides also composed of benzene rings and positively charged amino acids, this short peptide exhibits excellent antibacterial efficacy and low hemolytic activity. Background technique

[0002] The emergence of strains resistant to traditional antibiotics has spurred the search for novel therapeutic agents, including many antimicrobial peptides of animal origin. It is now found that these antimicrobial peptides play a very important role in the innate defense mechanism of some hosts, including plants, insects, amphibians and mammals. These peptides may also have antibiotic activity against bacteria, fungi, and even some viruses, which can bind lipids (greater than 95 percent), rapidly dissociate the lipid bi...

Claims

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