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Aciclovir high-molecular hydrogel dressing and its preparation method

A polymer hydrogel and a technology for preparing solutions, which are applied in the fields of active ingredients of heterocyclic compounds, medical science, bandages, etc., can solve the problems of difficult control of dosage, poor oral absorption, contaminated clothes, etc. Controllable, convenient administration, and increased exposure time

Inactive Publication Date: 2008-10-08
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But acyclovir has poor oral absorption, and its external preparations such as ointment, cream, etc. have the disadvantages of polluting clothes in use, difficult control of dosage, and difficult and lasting drug effects.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Prepare solution A: fully dissolve 0.025g N,N'-methylenebisacrylamide in 3.5g acrylic acid at room temperature;

[0027] (2) Prepare solution B: dissolve 1 g of acyclovir powder in 10 mL of aqueous sodium hydroxide solution (0.22 g / mL);

[0028] (3) Prepare solution C: Mix 2.5mL polyvinyl alcohol aqueous solution (0.1g / mL), 3mL glycerin, 2mL potassium persulfate aqueous solution (0.02g / mL), and 1-2ml water until fully dissolved;

[0029] (4) Slowly add solution A to solution B dropwise, adjust the pH of the system to 6, add solution C and a small amount of cooling agent after fully reacting, stir evenly, pour into the mold, heat at 50°C to polymerize and cross-link to obtain acithin Lowe polymer hydrogel dressing.

[0030] (5) Cover both sides of the dressing with non-woven fabric and anti-adhesive film respectively.

[0031] Treated herpes zoster for 20 patients, 19 of them relieved in 1 day and recovered in 3 days, and 20 of them had no side effects.

Embodiment 2

[0033] (1) Preparation of solution A: fully dissolve 0.02g of N,N'-methylenebisacrylamide in 5g of acrylic acid at room temperature;

[0034] (2) Prepare solution B: dissolve 1.5 g of acyclovir powder in 15 mL of aqueous sodium hydroxide solution (0.2 g / mL);

[0035] (3) Prepare solution C: Mix 3mL polyvinyl alcohol aqueous solution (0.1g / mL), 3mL glycerin, 2mL potassium persulfate aqueous solution (0.02g / mL), and 1-2ml water until fully dissolved;

[0036] (4) Slowly add solution A to solution B dropwise, adjust the pH of the system to 6.5, add solution C and a small amount of cooling agent and penetration enhancer after fully reacting, stir evenly, pour into the mold, heat and polymerize at 55°C Lian Ji get acyclovir polymer hydrogel dressing.

[0037] (5) Cover both sides of the dressing with non-woven fabric and anti-adhesive film respectively.

[0038] Treated herpes zoster for 20 patients, 19 of them relieved in 1 day and recovered in 3 days, and 20 of them had no side...

Embodiment 3

[0040] (1) Prepare solution A: fully dissolve 0.03g of N,N'-methylenebisacrylamide in 4g of acrylic acid at room temperature;

[0041] (2) Prepare solution B: dissolve 2 g of acyclovir powder in 15 mL of aqueous sodium hydroxide solution (0.22 g / mL);

[0042] (3) Preparation of solution C: Mix 5mL polyvinyl alcohol aqueous solution (0.1g / mL), 5mL glycerin, 2mL potassium persulfate aqueous solution (0.02g / mL), and 1-2ml water until fully dissolved;

[0043] (4) Slowly add solution A to solution B dropwise, adjust the pH of the system to 7, add solution C and a small amount of cooling agent after fully reacting, stir evenly, pour it into a mold, heat at 60°C to polymerize and cross-link to obtain acithin Lowe polymer hydrogel dressing.

[0044] (5) Cover both sides of the dressing with non-woven fabric and anti-adhesive film respectively.

[0045] Treated herpes zoster for 20 patients, 19 of them relieved in half a day, recovered in 3 days, and 20 had no side effects.

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PUM

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Abstract

The invention discloses a making method of Asiluowei macromolecular gel dressing, which comprises the following steps: dissolving N, N'-methylene diacrylamide into acroleic acid completely to obtain solution A; dissolving Asiluowei powder into sodium hydroxide solution to obtain solution B; dissolving polyvinyl alcohol solution, glycerin, potassium persulfate solution and water completely to obtain solution C; dripping solution A into solution B to react; adding solution C; stirring evenly; pouring into mould; heating to polymerize and crosslink to obtain the product to treat herpes zoster.

Description

technical field [0001] The invention relates to a drug dressing, in particular to an acyclovir polymer hydrogel dressing and a preparation method thereof. Background technique [0002] Herpes zoster (herpes zoster) is an acute inflammatory skin disease caused by varicella-zoster virus. Its main feature is clustered vesicles distributed in clusters and bands along one peripheral nerve, accompanied by obvious neuralgia. The first infection manifests as chickenpox, and the virus can remain dormant in the dorsal root ganglia of the spinal cord for a long time later. The weakened immune function can induce the varicella zoster virus to reactivate, grow and reproduce, and spread to the skin along the peripheral nerves, resulting in herpes zoster. [0003] Acyclovir (ACV) has a highly selective inhibitory effect on herpes simplex virus (HSV) and varicella-zoster virus (VZV), and is one of the most effective antiviral drugs. ACV is gradually phosphorylated under the action of viral...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/44A61L15/24A61K31/522
Inventor 童真黄玮刘新星
Owner SOUTH CHINA UNIV OF TECH
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