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Bulley aconitne transdermal paster

A technology of scutellarin and transdermal patch, which is applied in other medical devices, sheet delivery, drug devices, etc., to achieve the effects of good safety, ensuring safety, and stable blood drug concentration

Inactive Publication Date: 2009-02-04
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are more than ten types of transdermal patch drugs on the market at home and abroad, mainly including nitroglycerin, Pediatric Pain, nicotine, testosterone, estradiol, clonidine, fentanyl, scopolamine, lidocaine, indomethacin Wait, there are still many species still in the declaration

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The transdermal patch described in this example is an adhesive matrix patch, consisting of a backing layer, a protective layer, and a drug-containing adhesive matrix (i.e., a drug reservoir). The materials used in each layer are as follows:

[0034] Backing layer: non-woven fabric

[0035] Protective layer: siliconized paper

[0036] Drug-containing adhesive skeleton: the formula is as follows (100 stickers):

[0037] Acrylic pressure sensitive adhesive 35g

[0038] Aconitin 2.5g

[0039] Azone 1.5g

[0040] Preparation process: Take aconitin, acrylate pressure-sensitive adhesive and Azone in the prescribed amount, add appropriate amount of ethyl acetate to dissolve, adjust to a suitable consistency, coat on the protective layer, and control the thickness of the coating. Dry at 70°C, cover with backing layer, and cut into proper shape and size.

Embodiment 2

[0042] The transdermal patch described in this example is an adhesive matrix patch, consisting of a backing layer, a protective layer, and a drug-containing adhesive matrix (i.e., a drug reservoir). The materials used in each layer are as follows:

[0043] Backing layer: non-woven fabric

[0044] Protective layer: polyester film

[0045] Drug-containing adhesive skeleton: the formula is as follows (100 stickers):

[0046] Polyacrylic resin pressure sensitive adhesive 30g

[0047] Aconitine 2g

[0048] Oleic acid 2g

[0049] The formula of polyacrylic resin pressure sensitive adhesive is:

[0050] Polyacrylic resin IV 20g

[0051] Succinic acid 1g

[0052] Dibutyl phthalate 10g

[0053] Acetone 80ml

[0054] Preparation Process:

[0055] 1. Preparation of polyacrylic resin pressure-sensitive adhesive: Dissolve the amount of succinic acid in acetone, then add polyacrylic acid resin and stir to dissolve, and finally add dibutyl phthalate and continue stirring for 20 minute...

Embodiment 3

[0058] The transdermal patch described in this example is an adhesive layer rate-limiting patch, which consists of a backing layer, a protective layer, a drug-containing adhesive skeleton (i.e. drug storage), and a four-layer structure of the adhesive layer. The materials are as follows:

[0059] Backing layer: polyester film

[0060] Protective layer: PTFE film

[0061] Adhesive layer: blank silicone pressure sensitive adhesive

[0062] Drug-containing viscose skeleton: the formula is as follows (100 stickers):

[0063] Silicone pressure sensitive adhesive 30g

[0064] Aconitine 1.0g

[0065] Azone 1.5g

[0066] Preparation Process:

[0067] 1. Preparation of drug-containing skeleton layer: Dissolve silicone pressure-sensitive adhesive, aconitin and Azone in an appropriate amount of ethyl acetate, adjust to a suitable consistency, and coat on the backing layer to control the coating thickness. Dry at 70°C.

[0068] 2. Preparation of adhesive layer: apply blank silicon...

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PUM

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Abstract

The present invention relates to a medicine plaster for external application, in particular, it is a transdermal plaster containing caowujiasu. Said plaster has medicine storage unit, back-lining layer and protecting layer. Said medicine storage unit is formed from caowujiasu and storage matrix, every plaster contains 0.1mg-100 mg of caowujiasu, and the rest is storage matrix. The medicine-releasing area of said plaster is 1 sq.cm-100 sq.cm, and the transdermal speed rate is 0.05 microgram / h.sq.cm, and its continuous medicine-releasing time is 1-12 days. Its theapeutic effect is reliable, quality is stable and convenient in application.

Description

technical field [0001] The invention relates to a medicinal patch for external use, in particular to a transdermal patch containing aconitin. Background technique [0002] Bulleaconitione A (Bulleyaconitione A), molecular formula C 35 h 49 o 10 N, molecular weight 643.77, is a colorless prismatic crystal. Soluble in ether, alcohol, acid water, insoluble in water, has strong analgesic and obvious anti-inflammatory effects. Experiments have proved that the analgesic effect of this product is central and closely related to the level of serotonin in the brain. Non-addictive. Its anti-inflammatory effect does not pass through the adrenal system, but is related to the suppression of PG levels; this product also has antipyretic and local anesthetic effects. After taking the medicine, there were no abnormal changes in the patients' ECG, EEG, liver and kidney function and urine routine examination compared with before taking the medicine. Clinically, this product has a good cu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/445A61K9/70A61P25/04A61M37/00
Inventor 翁伟宇赵逸虹徐惠南杨兆祥沈腾字文光
Owner KPC PHARM INC
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