Pharmaceutical composition for treating senile dementia
A composition and drug technology, applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems of unsure curative effect, low salvianolic acid, low content, etc.
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Embodiment 1
[0140] Take 100Kg of Danshen medicinal material (origin: Shandong, batch number 0411053), 30Kg of notoginseng medicinal material (origin: Yunnan, batch number 0412041), crush Danshen medicinal material into small pieces, soak in 8 times the amount of ethanol for 1 hour, heat and reflux for 0.5 hour, filter, and collect Ethanol filtrate, recover ethanol and concentrate to extract I with a relative density of 1.35; dregs are refluxed with 80% ethanol for 1 hour, filter, collect 80% ethanol filtrate, recover ethanol and concentrate to extract II with a relative density of 1.36 ;Finally, reflux with water heat for 1.5 hours, and concentrate the filtrate to the extract III with a relative density of 1.29; grind the notoginseng into a fine powder of more than 80 mesh, mix with the salvia extract I, II and III, and dry at about 90°C 36h, 55Kg of the prepared medicinal active part dry product (dry paste), moisture ≤ 5%. Measured by the above-mentioned high-performance liquid chromatog...
Embodiment 2
[0141]Example 2: Take 150Kg of Danshen medicinal material (origin: Shandong, batch number 0501001), 45Kg of Radix Notoginseng medicinal material (origin: Yunnan, batch number 0412041), break the Danshen medicinal material into small sections, soak in ethanol for 2 hours, heat reflux for 0.5 hour, filter, Collect the ethanol filtrate, recover ethanol and concentrate to obtain extract I; the dregs are refluxed with 80% ethanol for 0.5 hours, filter, collect 80% ethanol filtrate, recover ethanol and concentrate to obtain extract II; finally reflux with water for 1.5 hours, The filtrate was concentrated to obtain extract III. Crush Panax notoginseng into fine powder above 80 meshes, mix with Danshen extract I, II and III, and dry at about 80°C for 50 hours. A total of 72Kg of dry cream was obtained, and the moisture content was less than or equal to 5%.
[0142] Measured by the above-mentioned high-performance liquid chromatography method, each 1g dry paste contains 2.98mg of tan...
Embodiment 3
[0143] Example 3: take 100Kg of Danshen medicinal material (origin: Shandong, batch number 0501021), 30Kg of notoginseng medicinal material (origin: Yunnan, batch number 0501001), crush Danshen medicinal material into small pieces, soak in ethanol for 1 hour, heat reflux for 1 hour, filter, and collect Ethanol filtrate, recovered ethanol and concentrated to obtain extract I; dregs were refluxed with 80% ethanol for 0.5 hours, filtered, collected 80% ethanol filtrate, recovered ethanol and concentrated to obtain extract II; finally refluxed with water for 2 hours, the filtrate Concentrate to obtain extract III. Crush Panax notoginseng into a fine powder of more than 80 mesh, mix with Danshen extract I, II and III, and dry at about 75°C for 70 hours to obtain a dry paste of 50.66Kg with a water content of ≤5%.
[0144] Measured by the above-mentioned high-performance liquid chromatography method, each 1g dry paste contains 2.56mg of tanshinone IIA, 50.03mg of salvianolic acid B,...
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