Enteric-coated multilayer encapsulated probiotic microcapsule and preparation method thereof
A lactic acid bacteria microcapsule and microcapsule technology, applied in microcapsules, food preparation, capsule delivery and other directions, can solve the problems of difficult long-term storage, complex coating process, influence on bacterial activity, etc., and achieve extended storage time and short exposure time. , the effect of promoting absorption
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Embodiment 1
[0020] (1) Sodium alginate is made into 100ml of 2% solution, 100ml of 4% calcium chloride solution is prepared, and 100ml of 1%wt chitosan solution is prepared.
[0021] (2) Centrifuge 500 ml of lactic acid bacteria fermentation liquid to collect wet cells, and suspend the wet cells in 10 ml of physiological saline.
[0022] (3) Add the suspension of wet cells into the above-mentioned sodium alginate solution and mix evenly to obtain a suspension of sodium alginate cells.
[0023] (4) The sodium alginate cell suspension is made into micro-droplets, which are added into the above-mentioned calcium chloride solution and stirred to obtain calcium alginate microcapsule particles.
[0024] (5) The microcapsule particles were collected by centrifugation, and added to the above 1%wt chitosan solution for secondary coating.
[0025] (6) The multi-layer coated microcapsule particles were collected by centrifugation and freeze-dried.
[0026] (7) The diameter of the microcapsule part...
Embodiment 2
[0034] Centrifuge 500ml of bifidobacterium fermentation broth to collect wet bacteria, and dilute to 10ml with phosphate buffer solution with a pH value of 6.8. The obtained wet cell suspension was added to 100 ml of 2% sodium alginate solution and mixed evenly to obtain a sodium alginate cell suspension. The sodium alginate cell suspension is made into micro-droplets, which are added into 100 ml of 3% calcium chloride solution and stirred to obtain microcapsule particles coated with calcium alginate.
[0035] The microcapsule particles were collected by centrifugation, and then added to 100 ml of 2% chitosan solution for secondary coating.
[0036] The above-mentioned microcapsule particles are collected by centrifugation and freeze-dried. The diameter of the dried microcapsule particles is 10-100 μm. Enteric multi-layer coated probiotic microcapsules were obtained.
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